1IJU

HUMAN BETA-DEFENSIN-1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ijua_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1ijuc_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1ijub_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1ijud_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Defensin-like	8036626	3000681	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Defensin-like	8036626	3000681	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Defensin-like	8036626	3000681	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Defensin-like	8036626	3000681	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Defensin_beta	e1ijuA1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
C	Defensin_beta	e1ijuC1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
B	Defensin_beta	e1ijuB1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)
D	Defensin_beta	e1ijuD1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_beta	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00711	Beta defensin (Defensin_beta)	Beta defensin	The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonisation [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	BETA-DEFENSIN 1	CCR chemokine receptor binding protein binding binding signaling receptor binding cytokine receptor binding G protein-coupled receptor binding chemokine receptor binding CCR6 chemokine receptor binding identical protein binding	chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion immune response immune system process biological process involved in interspecies interaction between organisms innate immune response in mucosa response to other organism defense response defense response to symbiont response to biotic stimulus chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion immune response immune system process biological process involved in interspecies interaction between organisms innate immune response in mucosa response to other organism defense response defense response to symbiont response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus mucosal immune response organ or tissue specific immune response humoral immune response antimicrobial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide response to bacterium defense response to Gram-negative bacterium defense response to bacterium antibacterial humoral response positive regulation of locomotion regulation of cell motility regulation of cellular process regulation of reproductive process cellular process involved in reproduction in multicellular organism regulation of cilium-dependent cell motility positive regulation of flagellated sperm motility regulation of flagellated sperm motility cell differentiation anatomical structure development cell maturation developmental process regulation of biological process positive regulation of flagellated sperm motility involved in capacitation positive regulation of cilium-dependent cell motility regulation of microtubule-based movement developmental maturation regulation of cilium movement sperm capacitation anatomical structure maturation regulation of locomotion flagellated sperm motility germ cell development microtubule-based movement microtubule-based process cilium movement regulation of cilium movement involved in cell motility spermatid development spermatid differentiation sexual reproduction cellular developmental process spermatogenesis reproductive process positive regulation of biological process cell development developmental process involved in reproduction gamete generation cilium or flagellum-dependent cell motility cilium-dependent cell motility positive regulation of cell motility positive regulation of cilium movement cell motility positive regulation of cellular process positive regulation of reproductive process sperm motility multicellular organismal reproductive process biological regulation regulation of microtubule-based process cilium movement involved in cell motility male gamete generation cellular process cellular response to stimulus signaling G protein-coupled receptor signaling pathway signal transduction cell communication intracellular signal transduction calcium-mediated signaling intracellular signaling cassette defense response to Gram-positive bacterium	membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm membrane membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm membrane extracellular region extracellular exosome extracellular vesicle extracellular organelle extracellular space vesicle extracellular membrane-bounded organelle cell projection sperm midpiece cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection microvesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR001855	Beta-defensin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P60022	prostate cancer contact dermatitis sinusitis breast cancer Contact hypersensitivity esophageal adenocarcinoma interstitial cystitis osteosarcoma pancreatic intraductal papillary-mucinous carcinoma transitional cell carcinoma breast carcinoma Crohn disease lung cancer ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia prostate cancer contact dermatitis sinusitis breast cancer Contact hypersensitivity esophageal adenocarcinoma interstitial cystitis osteosarcoma pancreatic intraductal papillary-mucinous carcinoma transitional cell carcinoma breast carcinoma Crohn disease lung cancer ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis cystic fibrosis IgA glomerulonephritis malignant pancreatic neoplasm pancreatic ductal adenocarcinoma pituitary cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.