1CJF

PROFILIN BINDS PROLINE-RICH LIGANDS IN TWO DISTINCT AMIDE BACKBONE ORIENTATIONS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1cjfa_	Alpha and beta proteins (a+b)	Profilin-like	Profilin (actin-binding protein)	Profilin (actin-binding protein)	Profilin (actin-binding protein)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth B]	d1cjfb_	Alpha and beta proteins (a+b)	Profilin-like	Profilin (actin-binding protein)	Profilin (actin-binding protein)	Profilin (actin-binding protein)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Profilin (actin-binding protein)	8035507	3000452	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Profilin (actin-binding protein)	8035507	3000452	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Profilin	e1cjfA1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Profilin	ECOD (1.6)
C [auth B]	Profilin	e1cjfB1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Profilin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.450.30	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Dynein light chain 2a, cytoplasmic	CATH (4.3.0)
C [auth B]	3.30.450.30	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Dynein light chain 2a, cytoplasmic	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth C], D	PROTEIN (PROLINE PEPTIDE)	-	-	-
A, C [auth B]	PROTEIN (HUMAN PLATELET PROFILIN)	small GTPase binding protein binding binding enzyme binding GTPase binding RNA binding organic cyclic compound binding nucleic acid binding phosphoprotein binding phosphotyrosine residue binding protein phosphorylated amino acid binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding small GTPase binding protein binding binding enzyme binding GTPase binding RNA binding organic cyclic compound binding nucleic acid binding phosphoprotein binding phosphotyrosine residue binding protein phosphorylated amino acid binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding proline-rich region binding cytoskeletal protein binding actin binding cell adhesion molecule binding cadherin binding molecular function regulator activity adenyl-nucleotide exchange factor activity ATPase regulator activity actin monomer binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of actin filament-based process negative regulation of biological process regulation of actin filament bundle assembly cellular component organization cellular component biogenesis cellular component assembly actin filament bundle organization regulation of protein stability biological regulation regulation of biological quality protein stabilization regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of actin filament-based process negative regulation of biological process regulation of actin filament bundle assembly cellular component organization cellular component biogenesis cellular component assembly actin filament bundle organization negative regulation of cellular process actin filament-based process negative regulation of supramolecular fiber organization cellular component organization or biogenesis regulation of biological process regulation of actin filament organization negative regulation of cellular component organization actin cytoskeleton organization negative regulation of cytoskeleton organization actin filament organization negative regulation of actin filament bundle assembly regulation of cellular component biogenesis regulation of organelle organization organelle organization negative regulation of organelle organization actin filament bundle assembly regulation of actin cytoskeleton organization regulation of supramolecular fiber organization cellular process supramolecular fiber organization cytoskeleton organization stress fiber assembly negative regulation of stress fiber assembly actomyosin structure organization regulation of stress fiber assembly contractile actin filament bundle assembly regulation of actomyosin structure organization regulation of cellular component size regulation of protein-containing complex assembly protein-containing complex assembly negative regulation of protein polymerization regulation of actin filament polymerization negative regulation of actin filament polymerization protein polymerization actin polymerization or depolymerization actin filament polymerization protein-containing complex organization regulation of actin polymerization or depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of actin filament length regulation of anatomical structure size cell junction organization modification of postsynaptic actin cytoskeleton synapse organization modification of postsynaptic structure modification of synaptic structure multicellular organismal process embryonic epithelial tube formation chordate embryonic development tube formation embryo development multicellular organism development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching anatomical structure development epithelial tube morphogenesis system development developmental process morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue development anatomical structure morphogenesis tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure trans-synaptic signaling regulation of signaling modulation of chemical synaptic transmission signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication positive regulation of organelle organization positive regulation of cellular component organization positive regulation of biological process positive regulation of actin filament bundle assembly positive regulation of cellular process positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization positive regulation of supramolecular fiber organization positive regulation of protein-containing complex assembly positive regulation of protein polymerization positive regulation of actin filament polymerization developmental maturation synapse maturation RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of molecular function regulation of molecular function regulation of ATP-dependent activity positive regulation of ATP-dependent activity positive regulation of locomotion regulation of cell motility positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration cell migration regulation of multicellular organismal process epithelial cell migration cell motility regulation of epithelial cell migration locomotion epithelium migration regulation of locomotion cell projection organization ruffle organization plasma membrane bounded cell projection assembly ruffle assembly positive regulation of cell projection organization plasma membrane bounded cell projection organization regulation of cell projection organization regulation of cell projection assembly positive regulation of ruffle assembly regulation of plasma membrane bounded cell projection assembly regulation of ruffle assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane cell periphery cell cortex intracellular anatomical structure cytoplasm extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane cell periphery cell cortex intracellular anatomical structure cytoplasm extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytosol synapse glutamatergic synapse blood microparticle intracellular organelle cytoskeleton membraneless organelle intracellular membraneless organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B]	IPR005455	Profilin, eukaryotic type	Family
A, C [auth B]	IPR027310	Profilin conserved site	Conserved Site
A, C [auth B]	IPR005454	Profilin1/2/3, vertebrate	Family
A, C [auth B]	IPR036140	Profilin superfamily	Homologous Superfamily
A, C [auth B]	IPR048278	Profilin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C [auth B]	Pharos: P07737	amyotrophic lateral sclerosis amyotrophic lateral sclerosis type 18 esophageal squamous cell carcinoma Liver Cirrhosis, Experimental keloid pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor large cell medulloblastoma lymphoplasmacytic lymphoma medulloblastoma ovarian cancer pilocytic astrocytoma psoriasis Becker muscular dystrophy amyotrophic lateral sclerosis amyotrophic lateral sclerosis type 18 esophageal squamous cell carcinoma Liver Cirrhosis, Experimental keloid pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor large cell medulloblastoma lymphoplasmacytic lymphoma medulloblastoma ovarian cancer pilocytic astrocytoma psoriasis Becker muscular dystrophy glioblastoma malignant glioma myopathy pancreatic ductal adenocarcinoma plasma cell myeloma rheumatoid arthritis astrocytic tumor brain aneurysm lung adenocarcinoma malignant pancreatic neoplasm neurodegenerative disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.