1GKO
An Engineered Transthyretin Monomer that is Non-amyloidogenic - Unless Partially Denatured
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d1gkoa_ | All beta proteins | Prealbumin-like | Transthyretin (synonym: prealbumin) | Transthyretin (synonym: prealbumin) | Transthyretin (synonym: prealbumin) | HUMAN (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
C | d1gkoc_ | All beta proteins | Prealbumin-like | Transthyretin (synonym: prealbumin) | Transthyretin (synonym: prealbumin) | Transthyretin (synonym: prealbumin) | HUMAN (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
D | d1gkod_ | All beta proteins | Prealbumin-like | Transthyretin (synonym: prealbumin) | Transthyretin (synonym: prealbumin) | Transthyretin (synonym: prealbumin) | HUMAN (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B | d1gkob_ | All beta proteins | Prealbumin-like | Transthyretin (synonym: prealbumin) | Transthyretin (synonym: prealbumin) | Transthyretin (synonym: prealbumin) | HUMAN (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Transthyretin (synonym: prealbumin) | 8040289 | 3000848 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Transthyretin (synonym: prealbumin) | 8040289 | 3000848 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Transthyretin (synonym: prealbumin) | 8040289 | 3000848 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Transthyretin (synonym: prealbumin) | 8040289 | 3000848 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Transthyretin | e1gkoA1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Prealbumin-like | F: Transthyretin | ECOD (1.6) |
C | Transthyretin | e1gkoC1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Prealbumin-like | F: Transthyretin | ECOD (1.6) |
D | Transthyretin | e1gkoD1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Prealbumin-like | F: Transthyretin | ECOD (1.6) |
B | Transthyretin | e1gkoB1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Prealbumin-like | F: Transthyretin | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.60.40.180 | Mainly Beta | Sandwich | Immunoglobulin-like | Transthyretin/hydroxyisourate hydrolase domain | CATH (4.3.0) |
C | 2.60.40.180 | Mainly Beta | Sandwich | Immunoglobulin-like | Transthyretin/hydroxyisourate hydrolase domain | CATH (4.3.0) |
D | 2.60.40.180 | Mainly Beta | Sandwich | Immunoglobulin-like | Transthyretin/hydroxyisourate hydrolase domain | CATH (4.3.0) |
B | 2.60.40.180 | Mainly Beta | Sandwich | Immunoglobulin-like | Transthyretin/hydroxyisourate hydrolase domain | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00576 | HIUase/Transthyretin family (Transthyretin) | HIUase/Transthyretin family | This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR036817 | Transthyretin/hydroxyisourate hydrolase domain superfamily | Homologous Superfamily | |
IPR023418 | Transthyretin, thyroxine binding site | Binding Site | |
IPR023419 | Transthyretin, conserved site | Conserved Site | |
IPR023416 | Transthyretin/hydroxyisourate hydrolase domain | Domain | |
IPR000895 | Transthyretin/hydroxyisourate hydrolase | Family |