1O66

Crystal structure of 3-methyl-2-oxobutanoate hydroxymethyltransferase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1o66a1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Ketopantoate hydroxymethyltransferase PanB	Ketopantoate hydroxymethyltransferase PanB	(Neisseria meningitidis serogroup B ) [TaxId: 491 ],	SCOPe (2.08)
A	d1o66a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Neisseria meningitidis serogroup B ) [TaxId: 491 ],	SCOPe (2.08)
B	d1o66b1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Ketopantoate hydroxymethyltransferase PanB	Ketopantoate hydroxymethyltransferase PanB	(Neisseria meningitidis serogroup B ) [TaxId: 491 ],	SCOPe (2.08)
B	d1o66b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Neisseria meningitidis serogroup B ) [TaxId: 491 ],	SCOPe (2.08)
D	d1o66d1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Ketopantoate hydroxymethyltransferase PanB	Ketopantoate hydroxymethyltransferase PanB	(Neisseria meningitidis serogroup B ) [TaxId: 491 ],	SCOPe (2.08)
D	d1o66d2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Neisseria meningitidis serogroup B ) [TaxId: 491 ],	SCOPe (2.08)
E	d1o66e1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Ketopantoate hydroxymethyltransferase PanB	Ketopantoate hydroxymethyltransferase PanB	(Neisseria meningitidis serogroup B ) [TaxId: 491 ],	SCOPe (2.08)
E	d1o66e2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Neisseria meningitidis serogroup B ) [TaxId: 491 ],	SCOPe (2.08)
C	d1o66c1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Ketopantoate hydroxymethyltransferase PanB	Ketopantoate hydroxymethyltransferase PanB	(Neisseria meningitidis serogroup B ) [TaxId: 491 ],	SCOPe (2.08)
C	d1o66c2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Neisseria meningitidis serogroup B ) [TaxId: 491 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8037281	3000510	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8037281	3000510	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8037281	3000510	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8037281	3000510	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8037281	3000510	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pantoate_transf	e1o66A1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Pantoate_transf	ECOD (1.6)
B	Pantoate_transf	e1o66B1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Pantoate_transf	ECOD (1.6)
D	Pantoate_transf	e1o66D1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Pantoate_transf	ECOD (1.6)
E	Pantoate_transf	e1o66E1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Pantoate_transf	ECOD (1.6)
C	Pantoate_transf	e1o66C1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Pantoate_transf	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
B	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
D	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
E	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
C	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF02548	Ketopantoate hydroxymethyltransferase (Pantoate_transf)	Ketopantoate hydroxymethyltransferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	3-methyl-2-oxobutanoate hydroxymethyltransferase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding 3-methyl-2-oxobutanoate hydroxymethyltransferase activity transferase activity, transferring one-carbon groups transferase activity hydroxymethyl-, formyl- and related transferase activity catalytic activity	pantothenate metabolic process water-soluble vitamin biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process modified amino acid biosynthetic process carboxylic acid metabolic process modified amino acid metabolic process vitamin biosynthetic process amide biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process vitamin metabolic process biosynthetic process pantothenate metabolic process water-soluble vitamin biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process modified amino acid biosynthetic process carboxylic acid metabolic process modified amino acid metabolic process vitamin biosynthetic process amide biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process vitamin metabolic process biosynthetic process pantothenate biosynthetic process small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process amide metabolic process water-soluble vitamin metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR015813	Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR003700	Ketopantoate hydroxymethyltransferase	Family
A, B, C, D, E	IPR040442	Pyruvate kinase-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.