Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilydUTPase-like 8031769 4002970 SCOP2 (2022-06-29)
ASCOP2 SuperfamilydUTPase-like 8044147 3001957 SCOP2 (2022-06-29)
BSCOP2B SuperfamilydUTPase-like 8044147 3001957 SCOP2B (2022-06-29)
CSCOP2B SuperfamilydUTPase-like 8044147 3001957 SCOP2B (2022-06-29)
DSCOP2B SuperfamilydUTPase-like 8044147 3001957 SCOP2B (2022-06-29)
FSCOP2B SuperfamilydUTPase-like 8044147 3001957 SCOP2B (2022-06-29)
ESCOP2B SuperfamilydUTPase-like 8044147 3001957 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ADCDe1xs1A1 A: beta barrelsX: beta-clipH: dUTPase-like (From Topology)T: dUTPase-likeF: DCDECOD (1.6)
BDCDe1xs1B1 A: beta barrelsX: beta-clipH: dUTPase-like (From Topology)T: dUTPase-likeF: DCDECOD (1.6)
CDCDe1xs1C1 A: beta barrelsX: beta-clipH: dUTPase-like (From Topology)T: dUTPase-likeF: DCDECOD (1.6)
DDCDe1xs1D1 A: beta barrelsX: beta-clipH: dUTPase-like (From Topology)T: dUTPase-likeF: DCDECOD (1.6)
FDCDe1xs1F1 A: beta barrelsX: beta-clipH: dUTPase-like (From Topology)T: dUTPase-likeF: DCDECOD (1.6)
EDCDe1xs1E1 A: beta barrelsX: beta-clipH: dUTPase-like (From Topology)T: dUTPase-likeF: DCDECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF22769dCTP deaminase-like (DCD)dCTP deaminase-likeThis entry represents a dCTP deaminase (DCD) domain found in archaea and bacteria [1-5]. Methanococcus jannaschii, has a bifunctional enzyme DCD-DUT, that harbors both dCTP deaminase and dUTP pyrophosphatase activities [1].Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
Deoxycytidine triphosphate deaminase

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR033704dUTPase, trimericDomain
A, B, C, D, E
IPR036157dUTPase-like superfamilyHomologous Superfamily
A, B, C, D, E
IPR011962dCTP deaminaseFamily

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
A, C
dCTP deaminase  M-CSA #732

Deoxycytidine triphosphate deaminase (dCTP deaminase) from E. coli catalyses the deamination of dCTP producing ammonia and dUTP. The dUTP can be hydrolysed by dUTPase producing dUMP which is a precursor of dTTP. dCTP deaminase is inhibited by dTTP and by inorganic phosphate. Deamination of dCTP by dCTP deaminase provides about 80% of the dUMP used for dTMP synthesis in E. coli. The substrate of dCTP deaminase is the dCTP.Mg2+ complex but the magnesium does not have a catalytic role and no other metal ions are involved in catalysis.

Defined by 5 residues: ALA:A-124ARG:A-126GLU:A-138SER:C-111ARG:C-115
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