2VLW

Crystal structure of the muscarinic toxin MT7 diiodoTYR51 derivative.

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Snake toxin-like	8070337	3000545	SCOP2B (2022-06-29)
A	SCOP2 Family	Snake venom toxins	8070336	4003278	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Snake toxin-like	8070337	3000545	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Toxin_TOLIP	e2vlwB1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: Toxin_TOLIP	ECOD (1.6)
A	Toxin_TOLIP	e2vlwA1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: Toxin_TOLIP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)
A	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21947	Snake toxin cobra-type (Toxin_cobra-type)	Snake toxin cobra-type	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	MUSCARINIC M1-TOXIN1	molecular function inhibitor activity protein binding binding signaling receptor binding molecular function regulator activity signaling receptor inhibitor activity receptor antagonist activity signaling receptor regulator activity toxin activity	-	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR018354	Snake toxin, conserved site	Conserved Site
A, B	IPR045860	Snake toxin-like superfamily	Homologous Superfamily
A, B	IPR054131	Snake toxin cobra-type	Family
A, B	IPR003571	Snake three-finger toxin	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Monotopic/peripheral	All beta monotopic/peripheral	Snake toxin-like	Snake venom toxins

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B	TYI	Parent Component: TYR RESID: AA0510 PSI-MOD : 3',5'-diiodo-L-tyrosine MOD:01613

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.