Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase
External Resource: Annotation
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
B | SCOP2B Superfamily | Ribonuclease H-like | 8077042 | 3000143 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Ribonuclease H-like | 8077042 | 3000143 | SCOP2B (2022-06-29) |
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
B | rve | e3ao4B1 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: Ribonuclease H-like (From Topology) | T: Ribonuclease H-like | F: rve | ECOD (1.6) |
A | rve | e3ao4A1 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: Ribonuclease H-like (From Topology) | T: Ribonuclease H-like | F: rve | ECOD (1.6) |
Chains | Polymer | Molecular Function | Biological Process | Cellular Component |
---|
| POL polyprotein | - catalytic activity, acting on RNA
- RNA exonuclease activity, producing 5'-phosphomonoesters
- catalytic activity, acting on a nucleic acid
- RNA exonuclease activity
- RNA nuclease activity
- hydrolase activity
- exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
- nuclease activity
- hydrolase activity, acting on ester bonds
- exoribonuclease H activity
- exonuclease activity
- catalytic activity
- DNA binding
- binding
- organic cyclic compound binding
- nucleic acid binding
- aspartic-type peptidase activity
- peptidase activity
- catalytic activity, acting on a protein
- aspartic-type endopeptidase activity
- endopeptidase activity
- endonuclease activity
- RNA endonuclease activity, producing 5'-phosphomonoesters
- RNA-DNA hybrid ribonuclease activity
- RNA endonuclease activity
- endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
- RNA-directed DNA polymerase activity
- catalytic activity, acting on DNA
- DNA polymerase activity
- transferase activity
- nucleotidyltransferase activity
- transferase activity, transferring phosphorus-containing groups
- RNA binding
- RNA stem-loop binding
- cation binding
- transition metal ion binding
- zinc ion binding
- ion binding
- metal ion binding
- small molecule binding
| | - |
Chains | Accession | Name | Type |
---|
| IPR036397 | Ribonuclease H superfamily | Homologous Superfamily |
| IPR043128 | Reverse transcriptase/Diguanylate cyclase domain | Homologous Superfamily |
| IPR001995 | Peptidase A2A, retrovirus, catalytic | Domain |
| IPR021109 | Aspartic peptidase domain superfamily | Homologous Superfamily |
| IPR001969 | Aspartic peptidase, active site | Active Site |
| IPR036862 | Integrase, C-terminal domain superfamily, retroviral | Homologous Superfamily |
| IPR012337 | Ribonuclease H-like superfamily | Homologous Superfamily |
| IPR018061 | Retropepsins | Domain |
| IPR017856 | Integrase-like, N-terminal | Homologous Superfamily |
| IPR010661 | Reverse transcriptase thumb | Domain |
| IPR002156 | Ribonuclease H domain | Domain |
| IPR003308 | Integrase, N-terminal zinc-binding domain | Domain |
| IPR001584 | Integrase, catalytic core | Domain |
| IPR043502 | DNA/RNA polymerase superfamily | Homologous Superfamily |
| IPR001037 | Integrase, C-terminal, retroviral | Domain |
| IPR034170 | Retropepsin-like catalytic domain | Domain |
| IPR000477 | Reverse transcriptase domain | Domain |
| IPR010659 | Reverse transcriptase connection | Domain |