3BIC
Crystal structure of human methylmalonyl-CoA mutase
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | MM_CoA_mutase | e3bicB1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: MM_CoA_mutase | ECOD (1.6) |
B | B12-binding | e3bicB2 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Class I glutamine amidotransferase-like | T: CheY-like | F: B12-binding | ECOD (1.6) |
A | MM_CoA_mutase | e3bicA1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: MM_CoA_mutase | ECOD (1.6) |
A | B12-binding | e3bicA2 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Class I glutamine amidotransferase-like | T: CheY-like | F: B12-binding | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 3.20.20.240 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Methylmalonyl-CoA mutase | CATH (4.3.0) |
B | 3.40.50.280 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Cobalamin-binding domain | CATH (4.3.0) |
A | 3.20.20.240 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Methylmalonyl-CoA mutase | CATH (4.3.0) |
A | 3.40.50.280 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Cobalamin-binding domain | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02310 | B12 binding domain (B12-binding) | B12 binding domain | This domain binds to B12 (adenosylcobamide)[1-3], it is found in several enzymes, such as glutamate mutase Swiss:Q05488, methionine synthase Swiss:Q99707 and methylmalonyl-CoA mutase Swiss:P22033. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, ... | Domain | |
PF01642 | Methylmalonyl-CoA mutase (MM_CoA_mutase) | Methylmalonyl-CoA mutase | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR006098 | Methylmalonyl-CoA mutase, alpha chain, catalytic | Domain | |
IPR006158 | Cobalamin (vitamin B12)-binding domain | Domain | |
IPR006099 | Methylmalonyl-CoA mutase, alpha/beta chain, catalytic | Domain | |
IPR036724 | Cobalamin-binding domain superfamily | Homologous Superfamily | |
IPR006159 | Methylmalonyl-CoA mutase, C-terminal | Domain | |
IPR016176 | Cobalamin (vitamin B12)-dependent enzyme, catalytic | Homologous Superfamily |