3FC6
hRXRalpha & mLXRalpha with an indole Pharmacophore, SB786875
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
C | d3fc6c_ | All alpha proteins | Nuclear receptor ligand-binding domain | Nuclear receptor ligand-binding domain | Nuclear receptor ligand-binding domain | Retinoid-X receptor alpha (RXR-alpha) | (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A | d3fc6a_ | All alpha proteins | Nuclear receptor ligand-binding domain | Nuclear receptor ligand-binding domain | Nuclear receptor ligand-binding domain | Retinoid-X receptor alpha (RXR-alpha) | (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B | d3fc6b_ | All alpha proteins | Nuclear receptor ligand-binding domain | Nuclear receptor ligand-binding domain | Nuclear receptor ligand-binding domain | automated matches | (Mus musculus ) [TaxId: 10090 ], | SCOPe (2.08) |
D | d3fc6d_ | All alpha proteins | Nuclear receptor ligand-binding domain | Nuclear receptor ligand-binding domain | Nuclear receptor ligand-binding domain | automated matches | (Mus musculus ) [TaxId: 10090 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
C | SCOP2B Superfamily | Nuclear receptor ligand-binding domain | 8038695 | 3001442 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Nuclear receptor ligand-binding domain | 8038695 | 3001442 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Nuclear receptor ligand-binding domain | 8032622 | 3001442 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Nuclear receptor ligand-binding domain | 8032622 | 3001442 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
C | Hormone_recep | e3fc6C1 | A: alpha arrays | X: Nuclear receptor ligand-binding domain (From Topology) | H: Nuclear receptor ligand-binding domain (From Topology) | T: Nuclear receptor ligand-binding domain | F: Hormone_recep | ECOD (1.6) |
A | Hormone_recep | e3fc6A1 | A: alpha arrays | X: Nuclear receptor ligand-binding domain (From Topology) | H: Nuclear receptor ligand-binding domain (From Topology) | T: Nuclear receptor ligand-binding domain | F: Hormone_recep | ECOD (1.6) |
B | Hormone_recep | e3fc6B1 | A: alpha arrays | X: Nuclear receptor ligand-binding domain (From Topology) | H: Nuclear receptor ligand-binding domain (From Topology) | T: Nuclear receptor ligand-binding domain | F: Hormone_recep | ECOD (1.6) |
D | Hormone_recep | e3fc6D1 | A: alpha arrays | X: Nuclear receptor ligand-binding domain (From Topology) | H: Nuclear receptor ligand-binding domain (From Topology) | T: Nuclear receptor ligand-binding domain | F: Hormone_recep | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
C | 1.10.565.10 | Mainly Alpha | Orthogonal Bundle | Retinoid X Receptor | Retinoid X Receptor | CATH (4.3.0) |
A | 1.10.565.10 | Mainly Alpha | Orthogonal Bundle | Retinoid X Receptor | Retinoid X Receptor | CATH (4.3.0) |
B | 1.10.565.10 | Mainly Alpha | Orthogonal Bundle | Retinoid X Receptor | Retinoid X Receptor | CATH (4.3.0) |
D | 1.10.565.10 | Mainly Alpha | Orthogonal Bundle | Retinoid X Receptor | Retinoid X Receptor | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00104 | Ligand-binding domain of nuclear hormone receptor (Hormone_recep) | Ligand-binding domain of nuclear hormone receptor | This all helical domain is involved in binding the hormone in these receptors. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR001628 | Zinc finger, nuclear hormone receptor-type | Domain | |
IPR021780 | Nuclear/hormone receptor activator site AF-1 | Domain | |
IPR013088 | Zinc finger, NHR/GATA-type | Homologous Superfamily | |
IPR000003 | Retinoid X receptor/HNF4 | Family | |
IPR050274 | Nuclear hormone receptor family NR2 subfamily | Family | |
IPR001723 | Nuclear hormone receptor | Family | |
IPR000536 | Nuclear hormone receptor, ligand-binding domain | Domain | |
IPR035500 | Nuclear hormone receptor-like domain superfamily | Homologous Superfamily | |
IPR001628 | Zinc finger, nuclear hormone receptor-type | Domain | |
IPR013088 | Zinc finger, NHR/GATA-type | Homologous Superfamily | |
IPR023257 | Liver X receptor | Family | |
IPR050234 | Nuclear hormone receptor family NR1 subfamily | Family | |
IPR001723 | Nuclear hormone receptor | Family | |
IPR000536 | Nuclear hormone receptor, ligand-binding domain | Domain | |
IPR035500 | Nuclear hormone receptor-like domain superfamily | Homologous Superfamily |