4PJT
Structure of PARP1 catalytic domain bound to inhibitor BMN 673
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
D | SCOP2B Superfamily | Domain of poly(ADP-ribose) polymerase | 8036812 | 3000280 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | ADP-ribosylation | 8036814 | 3001208 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Domain of poly(ADP-ribose) polymerase | 8036812 | 3000280 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | ADP-ribosylation | 8036814 | 3001208 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | ADP-ribosylation | 8036814 | 3001208 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Domain of poly(ADP-ribose) polymerase | 8036812 | 3000280 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | ADP-ribosylation | 8036814 | 3001208 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Domain of poly(ADP-ribose) polymerase | 8036812 | 3000280 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
D | PARP_reg | e4pjtD2 | A: alpha bundles | X: Domain of poly(ADP-ribose) polymerase (From Topology) | H: Domain of poly(ADP-ribose) polymerase (From Topology) | T: Domain of poly(ADP-ribose) polymerase | F: PARP_reg | ECOD (1.6) |
D | PARP | e4pjtD1 | A: a+b complex topology | X: ADP-ribosylation (From Topology) | H: ADP-ribosylation (From Topology) | T: ADP-ribosylation | F: PARP | ECOD (1.6) |
A | PARP_reg | e4pjtA2 | A: alpha bundles | X: Domain of poly(ADP-ribose) polymerase (From Topology) | H: Domain of poly(ADP-ribose) polymerase (From Topology) | T: Domain of poly(ADP-ribose) polymerase | F: PARP_reg | ECOD (1.6) |
A | PARP | e4pjtA1 | A: a+b complex topology | X: ADP-ribosylation (From Topology) | H: ADP-ribosylation (From Topology) | T: ADP-ribosylation | F: PARP | ECOD (1.6) |
B | PARP_reg | e4pjtB2 | A: alpha bundles | X: Domain of poly(ADP-ribose) polymerase (From Topology) | H: Domain of poly(ADP-ribose) polymerase (From Topology) | T: Domain of poly(ADP-ribose) polymerase | F: PARP_reg | ECOD (1.6) |
B | PARP | e4pjtB1 | A: a+b complex topology | X: ADP-ribosylation (From Topology) | H: ADP-ribosylation (From Topology) | T: ADP-ribosylation | F: PARP | ECOD (1.6) |
C | PARP_reg | e4pjtC2 | A: alpha bundles | X: Domain of poly(ADP-ribose) polymerase (From Topology) | H: Domain of poly(ADP-ribose) polymerase (From Topology) | T: Domain of poly(ADP-ribose) polymerase | F: PARP_reg | ECOD (1.6) |
C | PARP | e4pjtC1 | A: a+b complex topology | X: ADP-ribosylation (From Topology) | H: ADP-ribosylation (From Topology) | T: ADP-ribosylation | F: PARP | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
D | 1.20.142.10 | Mainly Alpha | Up-down Bundle | Poly(ADP-ribose) Polymerase | domain 1 | CATH (4.3.0) |
D | 3.90.228.10 | Alpha Beta | Alpha-Beta Complex | Phosphoenolpyruvate Carboxykinase | domain 3 | CATH (4.3.0) |
A | 1.20.142.10 | Mainly Alpha | Up-down Bundle | Poly(ADP-ribose) Polymerase | domain 1 | CATH (4.3.0) |
A | 3.90.228.10 | Alpha Beta | Alpha-Beta Complex | Phosphoenolpyruvate Carboxykinase | domain 3 | CATH (4.3.0) |
B | 1.20.142.10 | Mainly Alpha | Up-down Bundle | Poly(ADP-ribose) Polymerase | domain 1 | CATH (4.3.0) |
B | 3.90.228.10 | Alpha Beta | Alpha-Beta Complex | Phosphoenolpyruvate Carboxykinase | domain 3 | CATH (4.3.0) |
C | 1.20.142.10 | Mainly Alpha | Up-down Bundle | Poly(ADP-ribose) Polymerase | domain 1 | CATH (4.3.0) |
C | 3.90.228.10 | Alpha Beta | Alpha-Beta Complex | Phosphoenolpyruvate Carboxykinase | domain 3 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00644 | Poly(ADP-ribose) polymerase catalytic domain (PARP) | Poly(ADP-ribose) polymerase catalytic domain | - | Family | |
PF02877 | Poly(ADP-ribose) polymerase, regulatory domain (PARP_reg) | Poly(ADP-ribose) polymerase, regulatory domain | Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR038650 | PADR1, C-terminal domain superfamily | Homologous Superfamily | |
IPR050800 | ADP-ribosyltransferase diphtheria toxin-like | Family | |
IPR001510 | Zinc finger, PARP-type | Domain | |
IPR012982 | PARP1-like, PADR1 domain, zinc ribbon fold | Domain | |
IPR049296 | PARP1-like, PADR1 domain, N-terminal helical subdomain | Domain | |
IPR012317 | Poly(ADP-ribose) polymerase, catalytic domain | Domain | |
IPR036957 | Zinc finger, PARP-type superfamily | Homologous Superfamily | |
IPR001357 | BRCT domain | Domain | |
IPR036930 | WGR domain superfamily | Homologous Superfamily | |
IPR008893 | WGR domain | Domain | |
IPR036420 | BRCT domain superfamily | Homologous Superfamily | |
IPR036616 | Poly(ADP-ribose) polymerase, regulatory domain superfamily | Homologous Superfamily | |
IPR004102 | Poly(ADP-ribose) polymerase, regulatory domain | Domain | |
IPR008288 | Poly [ADP-ribose] polymerase | Family |