Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
DSCOP2B SuperfamilyDomain of poly(ADP-ribose) polymerase 8036812 3000280 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyADP-ribosylation 8036814 3001208 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyDomain of poly(ADP-ribose) polymerase 8036812 3000280 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyADP-ribosylation 8036814 3001208 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyADP-ribosylation 8036814 3001208 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyDomain of poly(ADP-ribose) polymerase 8036812 3000280 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyADP-ribosylation 8036814 3001208 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyDomain of poly(ADP-ribose) polymerase 8036812 3000280 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
DPARP_rege4pjtD2 A: alpha bundlesX: Domain of poly(ADP-ribose) polymerase (From Topology)H: Domain of poly(ADP-ribose) polymerase (From Topology)T: Domain of poly(ADP-ribose) polymeraseF: PARP_regECOD (1.6)
DPARPe4pjtD1 A: a+b complex topologyX: ADP-ribosylation (From Topology)H: ADP-ribosylation (From Topology)T: ADP-ribosylationF: PARPECOD (1.6)
APARP_rege4pjtA2 A: alpha bundlesX: Domain of poly(ADP-ribose) polymerase (From Topology)H: Domain of poly(ADP-ribose) polymerase (From Topology)T: Domain of poly(ADP-ribose) polymeraseF: PARP_regECOD (1.6)
APARPe4pjtA1 A: a+b complex topologyX: ADP-ribosylation (From Topology)H: ADP-ribosylation (From Topology)T: ADP-ribosylationF: PARPECOD (1.6)
BPARP_rege4pjtB2 A: alpha bundlesX: Domain of poly(ADP-ribose) polymerase (From Topology)H: Domain of poly(ADP-ribose) polymerase (From Topology)T: Domain of poly(ADP-ribose) polymeraseF: PARP_regECOD (1.6)
BPARPe4pjtB1 A: a+b complex topologyX: ADP-ribosylation (From Topology)H: ADP-ribosylation (From Topology)T: ADP-ribosylationF: PARPECOD (1.6)
CPARP_rege4pjtC2 A: alpha bundlesX: Domain of poly(ADP-ribose) polymerase (From Topology)H: Domain of poly(ADP-ribose) polymerase (From Topology)T: Domain of poly(ADP-ribose) polymeraseF: PARP_regECOD (1.6)
CPARPe4pjtC1 A: a+b complex topologyX: ADP-ribosylation (From Topology)H: ADP-ribosylation (From Topology)T: ADP-ribosylationF: PARPECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF00644Poly(ADP-ribose) polymerase catalytic domain (PARP)Poly(ADP-ribose) polymerase catalytic domain- Family
A, B, C, D
PF02877Poly(ADP-ribose) polymerase, regulatory domain (PARP_reg)Poly(ADP-ribose) polymerase, regulatory domainPoly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active [2].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D
Poly [ADP-ribose] polymerase 1