Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8003766 3000071 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8003766 3000071 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8054547 3000071 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8054547 3000071 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMHC antigen-recognition domain 8033653 3000521 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8054579 3000071 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyMHC antigen-recognition domain 8033653 3000521 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8054579 3000071 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BC1-set_2e5c09B1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_2ECOD (1.6)
GC1-set_2e5c09G1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_2ECOD (1.6)
DDUF1968e5c09D2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: DUF1968ECOD (1.6)
DV-set_4e5c09D1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_4ECOD (1.6)
IDUF1968e5c09I2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: DUF1968ECOD (1.6)
IV-set_4e5c09I1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_4ECOD (1.6)
EC1-sete5c09E1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-setECOD (1.6)
EV-set_3e5c09E2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_3ECOD (1.6)
JC1-sete5c09J1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-setECOD (1.6)
JV-set_3e5c09J2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_3ECOD (1.6)
AC1-set_2e5c09A2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_2ECOD (1.6)
AMHC_Ie5c09A1 A: a+b two layersX: MHC antigen-recognition domain (From Topology)H: MHC antigen-recognition domain (From Topology)T: MHC antigen-recognition domainF: MHC_IECOD (1.6)
FC1-set_2e5c09F2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_2ECOD (1.6)
FMHC_Ie5c09F1 A: a+b two layersX: MHC antigen-recognition domain (From Topology)H: MHC antigen-recognition domain (From Topology)T: MHC antigen-recognition domainF: MHC_IECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
B, G
MH1 HLA-A2 B2M Homo sapiens (human) B2M*01, B2M*02 C-LIKE-DOMAIN C-LIKE MH MH1-ALPHA_B2M IMGT (202448-0)
D, I
1E6 TR TR-ALPHA Homo sapiens (human) TRAV12-3*01, TRAJ12*01, TRAC*01 V-DOMAIN V-ALPHA, C-DOMAIN C-ALPHA TR TR-ALPHA_BETA-2 IMGT (202448-0)
E, J
1E6 TR TR-BETA-2 Homo sapiens (human) TRBV12-4*01, TRBJ2-4*01, TRBC2*01, TRBC2*02 V-DOMAIN V-BETA, C-DOMAIN C-BETA-2 TR TR-ALPHA_BETA-2 IMGT (202448-0)
A, F
MH1 HLA-A2 I-ALPHA Homo sapiens (human) HLA-A*0201 G-DOMAIN G-ALPHA1, G-DOMAIN G-ALPHA2, C-LIKE-DOMAIN C-LIKE MH MH1-ALPHA_B2M IMGT (202448-0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
B, G
PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain
D, I
PF07686Immunoglobulin V-set domain (V-set)Immunoglobulin V-set domainThis domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.Domain
D, I
PF09291Domain of unknown function (DUF1968) (DUF1968)Domain of unknown function (DUF1968)Members of this family are found in mammalian T-cell antigen receptor, and adopt an immunoglobulin-like beta-sandwich fold, with seven strands in two beta-sheets in a Greek-key topology. Their exact function has not, as yet, been determined.Domain
E, J
PF07686Immunoglobulin V-set domain (V-set)Immunoglobulin V-set domainThis domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.Domain
E, J
PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain
A, F
PF00129Class I Histocompatibility antigen, domains alpha 1 and 2 (MHC_I)Class I Histocompatibility antigen, domains alpha 1 and 2- Domain
A, F
PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
B, G
Beta-2-microglobulin
D, I
1E6 TCR Alpha Chain
E, J
1E6 TCR Beta Chain-
A, F
HLA class I histocompatibility antigen, A-2 alpha chain
C, H
Marker peptide---

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
B, G
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
B, G
IPR003006Immunoglobulin/major histocompatibility complex, conserved siteConserved Site
B, G
IPR013783Immunoglobulin-like foldHomologous Superfamily
B, G
IPR007110Immunoglobulin-like domainDomain
B, G
IPR050160Major Histocompatibility Complex/ImmunoglobulinFamily
B, G
IPR003597Immunoglobulin C1-setDomain
B, G
IPR015707Beta-2-MicroglobulinFamily
D, I
IPR051006T cell receptor variable domainFamily
D, I
IPR013783Immunoglobulin-like foldHomologous Superfamily
D, I
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
D, I
IPR013106Immunoglobulin V-set domainDomain
D, I
IPR007110Immunoglobulin-like domainDomain
D, I
IPR052051T cell receptor complex componentFamily
D, I
IPR013783Immunoglobulin-like foldHomologous Superfamily
D, I
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
D, I
IPR015370T-cell receptor alpha chain, constant domainDomain
E, J
IPR013783Immunoglobulin-like foldHomologous Superfamily
E, J
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
E, J
IPR013106Immunoglobulin V-set domainDomain
E, J
IPR007110Immunoglobulin-like domainDomain
E, J
IPR050413T cell receptor beta variableFamily
E, J
IPR003597Immunoglobulin C1-setDomain
E, J
IPR013783Immunoglobulin-like foldHomologous Superfamily
E, J
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
E, J
IPR007110Immunoglobulin-like domainDomain
E, J
IPR050380Immune Recognition and Response ModulatorsFamily
A, F
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
A, F
IPR010579MHC class I, alpha chain, C-terminalDomain
A, F
IPR011162MHC classes I/II-like antigen recognition proteinHomologous Superfamily
A, F
IPR001039MHC class I alpha chain, alpha1 alpha2 domainsDomain
A, F
IPR003006Immunoglobulin/major histocompatibility complex, conserved siteConserved Site
A, F
IPR013783Immunoglobulin-like foldHomologous Superfamily
A, F
IPR007110Immunoglobulin-like domainDomain
A, F
IPR050208Antigen-presenting and immune regulatory MHC class I-relatedFamily
A, F
IPR003597Immunoglobulin C1-setDomain
A, F
IPR011161MHC class I-like antigen recognition-likeDomain
A, F
IPR037055MHC class I-like antigen recognition-like superfamilyHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
B, G
PharosP61769
D, I
PharosP01848
E, J
PharosA0A5B9
A, F
PharosP04439