5DSY

Crystal structure of constitutively active PARP-2

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	PARP	e5dsyD1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: PARP	ECOD (1.6)
A	PARP	e5dsyA1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: PARP	ECOD (1.6)
B	PARP	e5dsyB1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: PARP	ECOD (1.6)
C	PARP	e5dsyC1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: PARP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	3.90.228.10	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase	domain 3	CATH (4.3.0)
A	3.90.228.10	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase	domain 3	CATH (4.3.0)
B	3.90.228.10	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase	domain 3	CATH (4.3.0)
C	3.90.228.10	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00644	Poly(ADP-ribose) polymerase catalytic domain (PARP)	Poly(ADP-ribose) polymerase catalytic domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Poly [ADP-ribose] polymerase 2	chromatin binding binding pentosyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity NAD+-protein ADP-ribosyltransferase activity transferase activity catalytic activity DNA binding organic cyclic compound binding damaged DNA binding nucleic acid binding NAD DNA ADP-ribosyltransferase activity ADP-D-ribose modification-dependent protein binding chromatin binding binding pentosyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity NAD+-protein ADP-ribosyltransferase activity transferase activity catalytic activity DNA binding organic cyclic compound binding damaged DNA binding nucleic acid binding NAD DNA ADP-ribosyltransferase activity ADP-D-ribose modification-dependent protein binding poly-ADP-D-ribose modification-dependent protein binding protein binding modification-dependent protein binding poly-ADP-D-ribose binding carbohydrate derivative binding NAD+-protein-aspartate ADP-ribosyltransferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups NAD+-protein-glutamate ADP-ribosyltransferase activity protein-containing complex binding nucleosome binding NAD+-protein poly-ADP-ribosyltransferase activity NAD+-protein-serine ADP-ribosyltransferase activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process DNA modification macromolecule modification metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process DNA modification macromolecule modification metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process DNA ADP-ribosylation neuron apoptotic process hippocampal neuron apoptotic process apoptotic process cell death programmed cell death DNA repair-dependent chromatin remodeling cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis regulation of biological process regulation of cellular process cell surface receptor signaling pathway signaling biological regulation extrinsic apoptotic signaling pathway cell communication apoptotic signaling pathway signal transduction response to decreased oxygen levels response to nutrient levels response to oxygen levels response to abiotic stimulus response to oxygen-glucose deprivation DNA repair developmental process multi-multicellular organism process multicellular organismal process placenta development reproductive process maternal process involved in female pregnancy multicellular organismal reproductive process animal organ development developmental process involved in reproduction tissue development maternal placenta development anatomical structure development female pregnancy multi-organism reproductive process decidualization base-excision repair regulation of growth system process regulation of cardiac muscle tissue growth developmental growth regulation of system process regulation of cell differentiation muscle cell differentiation regulation of muscle hypertrophy muscle structure development positive regulation of developmental process multicellular organism development muscle adaptation cell differentiation regulation of organ growth regulation of heart growth cardiac muscle tissue growth muscle tissue development cardiac cell development positive regulation of developmental growth positive regulation of heart growth system development heart growth positive regulation of organ growth striated muscle hypertrophy positive regulation of muscle cell differentiation regulation of muscle cell differentiation regulation of response to stimulus positive regulation of muscle hypertrophy positive regulation of cardiac muscle tissue growth positive regulation of multicellular organismal process positive regulation of cell growth involved in cardiac muscle cell development striated muscle cell differentiation regulation of cellular component organization cellular developmental process regulation of developmental process cardiac muscle cell development positive regulation of cardiac muscle hypertrophy positive regulation of biological process cell development regulation of striated muscle cell differentiation organ growth cell growth striated muscle tissue development striated muscle cell development muscle cell development positive regulation of cell differentiation positive regulation of striated muscle cell differentiation cardiac muscle hypertrophy regulation of multicellular organismal process positive regulation of cellular process muscle hypertrophy regulation of muscle adaptation heart development regulation of multicellular organismal development regulation of developmental growth cardiac muscle tissue development developmental cell growth physiological muscle hypertrophy growth cardiac muscle cell differentiation regulation of cell growth involved in cardiac muscle cell development positive regulation of cell growth regulation of cell growth muscle system process regulation of muscle system process cardiocyte differentiation regulation of cardiac muscle hypertrophy circulatory system development cell growth involved in cardiac muscle cell development positive regulation of growth physiological cardiac muscle hypertrophy double-strand break repair protein poly-ADP-ribosylation protein metabolic process post-translational protein modification protein modification process protein auto-ADP-ribosylation	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen nucleoplasm site of DNA damage chromosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR012317	Poly(ADP-ribose) polymerase, catalytic domain	Domain
A, B, C, D	IPR050800	ADP-ribosyltransferase diphtheria toxin-like	Family
A, B, C, D	IPR036616	Poly(ADP-ribose) polymerase, regulatory domain superfamily	Homologous Superfamily
A, B, C, D	IPR036930	WGR domain superfamily	Homologous Superfamily
A, B, C, D	IPR004102	Poly(ADP-ribose) polymerase, regulatory domain	Domain
A, B, C, D	IPR008893	WGR domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q9UGN5	lipodystrophy ovarian cancer atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma Malignant epithelial tumor of ovary peripheral neuropathy Takayasu arteritis malignant glioma ovarian epithelial tumor psoriasis lung cancer peripheral nervous system disease subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.