5X29

NMR structure of the SARS Coronavirus E protein pentameric ion channel

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Small envelope protein E-like	8092029	3002552	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Small envelope protein E-like	8092029	3002552	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Small envelope protein E-like	8092029	3002552	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Small envelope protein E-like	8092029	3002552	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Small envelope protein E-like	8092029	3002552	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	NS3_envE_like	e5x29A1	A: extended segments	X: Envelope small membrane protein (From Topology)	H: Envelope small membrane protein (From Topology)	T: Envelope small membrane protein	F: NS3_envE_like	ECOD (1.6)
B	NS3_envE_like	e5x29B1	A: extended segments	X: Envelope small membrane protein (From Topology)	H: Envelope small membrane protein (From Topology)	T: Envelope small membrane protein	F: NS3_envE_like	ECOD (1.6)
D	NS3_envE_like	e5x29D1	A: extended segments	X: Envelope small membrane protein (From Topology)	H: Envelope small membrane protein (From Topology)	T: Envelope small membrane protein	F: NS3_envE_like	ECOD (1.6)
C	NS3_envE_like	e5x29C1	A: extended segments	X: Envelope small membrane protein (From Topology)	H: Envelope small membrane protein (From Topology)	T: Envelope small membrane protein	F: NS3_envE_like	ECOD (1.6)
E	NS3_envE_like	e5x29E1	A: extended segments	X: Envelope small membrane protein (From Topology)	H: Envelope small membrane protein (From Topology)	T: Envelope small membrane protein	F: NS3_envE_like	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF02723	Coronavirus small envelope protein E (CoV_E)	Coronavirus small envelope protein E	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	Envelope small membrane protein	identical protein binding protein binding binding	cellular process apoptotic process cell death programmed cell death virion assembly viral budding from Golgi membrane viral process viral budding viral life cycle disruption of cellular anatomical structure in another organism biological process involved in interspecies interaction between organisms disruption of anatomical structure in another organism disruption of plasma membrane integrity in another organism	cellular anatomical structure membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell endoplasmic reticulum-Golgi intermediate compartment host cell cytoplasm host cell part host intracellular region host cell cytoplasm part host intracellular organelle virion component virion membrane host cell Golgi membrane cellular anatomical structure membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell endoplasmic reticulum-Golgi intermediate compartment host cell cytoplasm host cell part host intracellular region host cell cytoplasm part host intracellular organelle virion component virion membrane host cell Golgi membrane host cell Golgi apparatus host cell membrane host cell endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR043506	Envelope small membrane protein, betacoronavirus	Family
A, B, C, D, E	IPR003873	Envelope small membrane protein, coronavirus	Family
A, B, C, D, E	IPR044377	Envelope small membrane protein, SARS-CoV-2-like	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E	OPM	Transmembrane	Bitopic proteins	Bitopic viroporins	Coronavirus E protein

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.