6V2F
Crystal structure of the HIV capsid hexamer bound to the small molecule long-acting inhibitor, GS-6207
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Retrovirus capsid dimerization domain-like | 8077054 | 3001819 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Retrovirus capsid dimerization domain-like | 8077054 | 3001819 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Retrovirus capsid dimerization domain-like | 8077054 | 3001819 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | Retrovirus capsid dimerization domain-like | 8077054 | 3001819 | SCOP2B (2022-06-29) |
F | SCOP2B Superfamily | Retrovirus capsid dimerization domain-like | 8077054 | 3001819 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Retrovirus capsid dimerization domain-like | 8077054 | 3001819 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Gag_p24_C | e6v2fA2 | A: alpha bundles | X: Retrovirus capsid protein | H: Retrovirus capsid protein-C (From Topology) | T: Retrovirus capsid protein-C | F: Gag_p24_C | ECOD (1.6) |
A | Gag_p24_N | e6v2fA1 | A: alpha bundles | X: Retrovirus capsid protein | H: Retrovirus capsid protein N-terminal domain (From Topology) | T: Retrovirus capsid protein N-terminal domain | F: Gag_p24_N | ECOD (1.6) |
B | Gag_p24_C | e6v2fB1 | A: alpha bundles | X: Retrovirus capsid protein | H: Retrovirus capsid protein-C (From Topology) | T: Retrovirus capsid protein-C | F: Gag_p24_C | ECOD (1.6) |
B | Gag_p24_N | e6v2fB2 | A: alpha bundles | X: Retrovirus capsid protein | H: Retrovirus capsid protein N-terminal domain (From Topology) | T: Retrovirus capsid protein N-terminal domain | F: Gag_p24_N | ECOD (1.6) |
C | Gag_p24_C | e6v2fC2 | A: alpha bundles | X: Retrovirus capsid protein | H: Retrovirus capsid protein-C (From Topology) | T: Retrovirus capsid protein-C | F: Gag_p24_C | ECOD (1.6) |
C | Gag_p24_N | e6v2fC1 | A: alpha bundles | X: Retrovirus capsid protein | H: Retrovirus capsid protein N-terminal domain (From Topology) | T: Retrovirus capsid protein N-terminal domain | F: Gag_p24_N | ECOD (1.6) |
E | Gag_p24_C | e6v2fE2 | A: alpha bundles | X: Retrovirus capsid protein | H: Retrovirus capsid protein-C (From Topology) | T: Retrovirus capsid protein-C | F: Gag_p24_C | ECOD (1.6) |
E | Gag_p24_N | e6v2fE1 | A: alpha bundles | X: Retrovirus capsid protein | H: Retrovirus capsid protein N-terminal domain (From Topology) | T: Retrovirus capsid protein N-terminal domain | F: Gag_p24_N | ECOD (1.6) |
F | Gag_p24_C | e6v2fF2 | A: alpha bundles | X: Retrovirus capsid protein | H: Retrovirus capsid protein-C (From Topology) | T: Retrovirus capsid protein-C | F: Gag_p24_C | ECOD (1.6) |
F | Gag_p24_N | e6v2fF1 | A: alpha bundles | X: Retrovirus capsid protein | H: Retrovirus capsid protein N-terminal domain (From Topology) | T: Retrovirus capsid protein N-terminal domain | F: Gag_p24_N | ECOD (1.6) |
D | Gag_p24_C | e6v2fD2 | A: alpha bundles | X: Retrovirus capsid protein | H: Retrovirus capsid protein-C (From Topology) | T: Retrovirus capsid protein-C | F: Gag_p24_C | ECOD (1.6) |
D | Gag_p24_N | e6v2fD1 | A: alpha bundles | X: Retrovirus capsid protein | H: Retrovirus capsid protein N-terminal domain (From Topology) | T: Retrovirus capsid protein N-terminal domain | F: Gag_p24_N | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00607 | gag protein p24 N-terminal domain (Gag_p24) | gag protein p24 N-terminal domain | p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus replication both in vivo and in vitro. | Domain | |
PF19317 | Gag protein p24 C-terminal domain (Gag_p24_C) | Gag protein p24 C-terminal domain | p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus replication both in vivo and in vitro. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR000071 | Immunodeficiency lentiviral matrix, N-terminal | Domain | |
IPR045345 | Retroviral nucleocapsid Gag protein p24, C-terminal domain | Domain | |
IPR036875 | Zinc finger, CCHC-type superfamily | Homologous Superfamily | |
IPR050195 | Primate lentivirus group Gag polyprotein-like | Domain | |
IPR001878 | Zinc finger, CCHC-type | Domain | |
IPR008919 | Retrovirus capsid, N-terminal | Homologous Superfamily | |
IPR010999 | Retroviral matrix protein | Homologous Superfamily | |
IPR012344 | Matrix protein, lentiviral and alpha-retroviral, N-terminal | Homologous Superfamily | |
IPR014817 | Gag protein p6 | Domain | |
IPR008916 | Retrovirus capsid, C-terminal | Homologous Superfamily |