4PZ

4-methyl-1H-pyrazole

Created:	2008-08-19
Last modified:	2011-06-04

Find Related PDB Entry
1 entries where 4PZ is found as a standalone ligand

Help Find related ligands:
Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Help

Find related ligands:

Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Chemical Details
Formal Charge	0
Atom Count	12
Chiral Atom Count	0
Bond Count	12
Aromatic Bond Count	5

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	4-methyl-1H-pyrazole
Systematic Name (OpenEye OEToolkits)	4-methyl-1H-pyrazole
Formula	C₄ H₆ N₂
Molecular Weight	82.104
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	n1cc(cn1)C
SMILES	CACTVS	3.341	Cc1c[nH]nc1
SMILES	OpenEye OEToolkits	1.5.0	Cc1c[nH]nc1
Canonical SMILES	CACTVS	3.341	Cc1c[nH]nc1
Canonical SMILES	OpenEye OEToolkits	1.5.0	Cc1c[nH]nc1
InChI	InChI	1.03	InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
InChIKey	InChI	1.03	RIKMMFOAQPJVMX-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB01213
Name	Fomepizole
Groups	approved vet_approved
Description	Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.
Synonyms	Fomepizolum 4-methylpyrazol Fomepizol Fomepizole sulfate Fomepizole 4-methylpyrazole
Brand Names	Fomepizole Fomepizole for Injection Antizol
Indication	Antizol is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis
Categories	Antidotes Compounds used in a research, industrial, or household setting Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strength unknown) Cytochrome P-450 CYP2E1 Inducers Cytochrome P-450 CYP2E1 Inducers (strength unknown) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (strength unknown) Cytochrome P-450 CYP2E1 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs that are Mainly Renally Excreted Enzyme Inhibitors Protective Agents Pyrazoles
ATC-Code	V03AB34
CAS number	7554-65-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Alcohol dehydrogenase 1A	MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAVGICGTD...	unknown	inhibitor
Alcohol dehydrogenase 1B	MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTD...	unknown	inhibitor
Alcohol dehydrogenase 1C	MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSD...	unknown	inhibitor
Catalase	MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPL...	unknown	inhibitor
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inhibitor
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	substrate,inhibitor,inducer
View More

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682