BTN

BIOTIN



Chemical Component Summary

NameBIOTIN
Identifiers5-[(3aS,4S,6aR)-2-oxidanylidene-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid
FormulaC10 H16 N2 O3 S
Molecular Weight244.311
TypeNON-POLYMER
Isomeric SMILESC1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)O)NC(=O)N2
InChIInChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
InChIKeyYBJHBAHKTGYVGT-ZKWXMUAHSA-N

Chemical Details

Formal Charge0
Atom Count32
Chiral Atom Count3
Bond Count33
Aromatic Bond Count0

Drug Info: DrugBank

DrugBank IDDB00121 
NameBiotin
Groups
  • approved
  • investigational
  • nutraceutical
DescriptionA water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.
Synonyms
  • 5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid
  • cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valeric acid
  • Vitamin B7
  • (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid
  • cis-Tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid
Brand Names
  • Formula F L W
  • Stress B With 1000 Mg Vitamin C
  • ProFola
  • Amerix Biotin
  • Mini-B Tab
IndicationFor nutritional supplementation, also for treating dietary shortage or imbalance.
Categories
  • Alimentary Tract and Metabolism
  • Coenzymes
  • Diet, Food, and Nutrition
  • Dietary Supplements
  • Enzymes and Coenzymes
ATC-CodeA11HA05
CAS number58-85-5

Drug Targets

NameTarget SequencePharmacological ActionActions
Propionyl-CoA carboxylase beta chain, mitochondrialMAAALRVAAVGARLSVLASGLRAAVRSLCSQATSVNERIENKRRTALLGG...unknowncofactor
Biotin--protein ligaseMEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLE...unknownsubstrate
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrialMWAVLRLALRPCARASPAGPRAYHGDSVASLGTQPDLGSALYQENYKQMK...unknowncofactor
Acetyl-CoA carboxylase 2MVLLLCLSCLIFSCLTFSWLKIWGKMTDSKPITKSKSEANLIPSQEPFPA...unknowncofactor
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrialMAAASAVSVLLVAAERNRWHRLPSLLLPPRTWVWRQRTMKYTTATGRNIT...unknowncofactor
View More
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
PubChem 171548
ChEMBL CHEMBL857
ChEBI CHEBI:15956
CCDC/CSD BIOTIN12, BIOTIN10, BIOTIN01