CL6

1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE

Created:	2006-10-26
Last modified:	2021-03-01

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9 entries where CL6 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	42
Chiral Atom Count	0
Bond Count	45
Aromatic Bond Count	23

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Chemical Component Summary
Name	1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE
Synonyms	CLOTRIMAZOLE
Systematic Name (OpenEye OEToolkits)	1-[(2-chlorophenyl)-diphenyl-methyl]imidazole
Formula	C₂₂ H₁₇ Cl N₂
Molecular Weight	344.837
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
Canonical SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
InChI	InChI	1.03	InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey	InChI	1.03	VNFPBHJOKIVQEB-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB00257
Name	Clotrimazole
Groups	approved vet_approved
Description	This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity [A174094]. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot [A174097].
Synonyms	1-(o-Chloro-α,α-diphenylbenzyl)imidazole 1-(α-(2-Chlorophenyl)benzhydryl)imidazole 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole Clotrimazolum 1-(o-Chlorotrityl)imidazole Clotrimazol Clotrimazole
Brand Names	First Aid Research Antifungal Cream 1oz CAREONE Clotrimazole Clotrimazole Cream 1% Lakesia Canesten 6 Day Internal Cream Neo-zol Cream 1% Terrasil Antifungal Cream Maximum Strength Athlete s Foot Afac Clotrimaderm External Cream Goodsense Athletes Foot Antifungal Cream Topcare Athletes Foot Rugby Antifungal Clotrimazole Rugby Clotrimazole Antifungal Cream Rite Aid antifungal ringworm Astonea Clotrimazole 1% Athletes Foot Au Kah Chuen Antifungal Gehwol Fusskraft Nail and Skin Protection Major Clotrimazole Scheinpharm Clotrimazole 1% Canesten Extra Strength External Antifungal Cream Clotrimazole External Antifungal Cream MakeSense Clotrimazole 1% Topical Antifungal Cream Clotrimazole Topical Pedesil Maximum Strength Clotrimaderm Topical Lucky SuperSoft Athletes Foot Ringworm Hua Tuo Xian Gao Antifungal Mycozyl AC Up and Up Jock Itch Relief Up and Up Athletes Foot TM-Clotrimazole Canesten V Lotrimin Antifungal Oheal Manuka Honey Eczema Cream Forticept Antifungal Foot Gel Gehwol Nail Protection Pen Myclo-gyne Inserts Clotrimazole Extra Strength External Antifungal Cream Ciclomazole Quality Choice Clotrimazole Rexall Jock Itch Terrasil Anti-Fungal Treatment Fungistat Max Clotrimazole/Betameth Clotrimaderm-fluconazole Combi-pack Good Neighbor Pharmacy Clotrimazole 3 Clotrimazole Vaginal 3 Footlogix Canesten External Cream Canesten 1 Day Internal Cream Terrasil Tinea Treatment Maximum Strength Thera plus Antifungal Clotrimazole Healthy Accents Antifungal Alevazol Clotrimaderm Vaginal 6 Canesten Liq 1% Canesten 1% Topical Cream Walgreens Clotrimazole 3 TheraPlus Plus Family Care Clotrimazole Anti-Fungal Cream 1% Canesten 1% Topical Solution Family Care Antifungal Gehwol med Foot Publix athletic foot Budpak Antifungal Clotrimazole Canesten Crm 1% Vag Kroger Jock Itch TerrasilMed ANTIFUNGAL Equaline Antifungal Cream Canesten Combi 1 Day Comfortab + Extra Strength External Cream Gerlasan Hand 1MED Clotrimazole 1% Antifungal Cream Athletes Foot Canesten 3 Vaginal Tablet Combi-pak Equate Jock Itch Dr Sheffield Athletes Foot PRO-EX Anti Fungal Shopko Athletes Foot Meijer Athletes Foot Cream AF Clotrimazol Soothing Antifungal Cream Kerasal foot and toe WinCo Antifungal Anti Fungal Fungicure Intensive Myclo Crm 50mg Good Neighbor Pharmacy Clotrimazole Clotrimaderm Vaginal 3 Clotrimazole External Cream Dermatin Antifungal Fungicure Pumpspray JiDeSheng Terrasil Jock Itch Treatment Maximum Strength Silka Ringworm Jock Itch Antifungal Athletes Foot Antifungal Antifungal Occulus SKIN HYDRATING TOPICAL FOAM CLO-1 ANTIFUNGAL FOAM Fungicure Manicure Pedicure Liquid Gel Antifungal Foot Mycelex PerfectHeal Antifungal Western Family Athletes Foot Forticept Antifungal Cooling Canesten 100mg Vaginal Inserts Walgreens Jock Itch Oheal Ringworm Cream PMS-clotrimazole-betamethasone Lotrimin Neo-zol Vaginal Cream 1% SoundBody Clotrimazole Antifungal Terrasil JockItch Treatment Maximum Strength ClotrimazOil Antifungal Taro-clotrimazole/betamethasone Dipropionate Canesoral Combi Gyne-Lotrimin 7 Canesten 2% Vaginal Cream SIMPLY VITAL Antifungal Cream sunmark Clotrimazole 3 Canesten Combi 3 Day Good Sense Athletes Foot antifungal Canesten Combi 1 Day Foot Care Clotrimazole Protective and Moisturizing Skin Canesten 3 Day Internal Cream Canesten Comfortab 1 Best Choice Clotrimazole Live Better Antifungal Signature Care Athletes Foot Terrasil Tinea Treatment MAX Zapotol Clotrimazole Clotrimazole and Betamethasone Dipropionate Skin Repair Terrasil Rapid-Clear Anti-Fungal Lotriderm Clotrimazole 1% Meijer Clotrimazole Antifungal Family Wellness Antifungal Smart Sense Athletes Foot Antifungal Extra Strength Clotrimazole Extra Fort -fluconazole Combi Myclo-derm Cream 1% TopCare Antifungal CVS Pharmacy ITCH RELIEF ANTIFUNGAL Canesten 200 Mg Vaginal Inserts Kleer-Plex Fungistat Fungus Cure Occulus Skin Hydrating Topical Foam CLO-1 TopCare Clotrimazole 3 Terrasil Foot and Nail Anti-Fungal Maximum Strength Clotrimazole DermacinRx Therazole Pak Hua Tuo Xian Gao Kroger ATHLETES FOOT Footlogix Intensive Care Diabetic Formula Myclo-derm Solution 1% Terrasil Foot and Nail Anti-Fungal Terrasil Anti-fungal Treatment Signature Care Antifungal Gyne-Lotrimin 3 Canesten Crm 1% Top Canesten Combi-pak 1 Day Therapy Forticept Antifungal Foot Cream UpandUp Clotrimazole Olp Clotrimazole Desenex Equaline Clotrimazole Antifungal Clotrimazole Vaginal 6 Votriza-AL Our Family Athletes Foot CAREALL Clotrimazole meijer Clotrimazole 3 S-Cream CLOTRIMAZOLE Cream 1% Anti-Fungal Cream Micotrin AC Anti-Fungal Canesoral Combi 1 Day Fungicure Manicure Pedicure Clotrimazol Dual Myclo Crm 10mg Walgreens Clotrimazole Fortinia Clotrimazole-fluconazole Combi Fastrin Anti - Fungal Skin Care HEB Antifungal Atopalm Clotrimazole Antifungal Clotrimazole Topical Solution 1% Family Wellness Clotrimazole 1 Anti Fungal Cream Myclo Tab 100mg Neo-zol Vaginal Cream 2% Jock-eze Femmesil Clotrimazole Antifungal Sunmark Clotrimazole Fungicure Liquid Gel CVS Antifungal Ringworm Aspiera Anti-Fungal Clotrimazole 1% Athletes Foot Cura Hongo Antifungal ShopRite antifungal Terrasil Anti-Fungal Treatment MAX Terrasil Ringworm Treatment MAX Shield and Protect Anti-Fungal Clotrimaderm Topical Solution 1% USP Jock Itch Clotrimazole Antifungal Clotrimazole Jock Itch Terbinafine HCl Chlortimazole and Tolnaftate Jock Itch Cream with Clotrimazole Lotrisone Clotrimazole Topical Solution USP, 1% CVS Clotrimazole Maximum Strength Antifungal Kleer-Plex Fungistat Athlete Foot Cure Canesten External Antifungal Cream FungaZoil Advanced Fungicure Manicure Pedicure Anti Fungal Leader Clotrimazole Anti-Fungal Exchange Select Atheletes foot Canesten 1 Vaginal Tablet Combi-pak Myclo Solution Fortinia OF Protective Nail and skin Quality Choice Athletes Foot Rexall Athletes Foot Canesten Comfortab 3 Canesten Combi 1 Day Internal + External Creams Clotrimazole Athletes Foot Leader Athletes Foot Clotrimazole Aptrimazole 1.0% Antifungal Cream Blossom Pharmaceuticals Antifungal Pedesil Canesten Vaginal Inserts 100mg CVS Pharmacy Clotrimazole 3 Family Care Clotrimazole Antifungal Smooth Gator Fungus Eliminator WinCo Foods Antifungal Akin Anti-fungal Dynarex Antifungal Myclo-gyne Cream 1% First Aid Research Antifungal .5oz Terrasil Athletes Foot AntiFungal Treatment Max Athlete Foot Cream with Clotrimazole Signature Care Jock Itch Terrasil Jock-Itch Treatment MAX Walgreens Clotrimazole Antifungal CVSHealth Antifungal Betamethasone Clotrimazole meijer Athletes Foot Botanimedix TineaRX Antifungal Drying Emulsion Jock Itch
Indication	Topical preparations Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections [F3088], [F3121]: Tinea pedis, tinea cruris, and tinea corporis due to _Trichophyton rubrum_, _Trichophyton mentagrophytes_, _Epidermophyton floccosum_ Candidiasis due to _Candida albicans_ Tinea versicolor due to _Malassezia furfur_ Diaper rash infected by _Candida albicans_ In some preparations, clotrimazole may be combined with betamethasone dipropionate, a corticosteroid [F3121]. Oral preparations The oral troche preparation is indicated for the local treatment of oropharyngeal candidiasis [FDA label]. It is also indicated as a prophylactic drug to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions such as chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation [FDA label]. Troche preparations are not indicated for the treatment of any systemic mycoses [FDA label].
Categories	Anti-Infective Agents Anti-Infective Agents, Local Antifungal Agents Antifungal Agents (Vaginal) Antifungals for Dermatological Use Antifungals for Topical Use Antiinfectives and Antiseptics for Local Oral Treatment Azole Antifungals BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strong) Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strong) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (moderate) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inducers (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A7 Inducers Cytochrome P-450 CYP3A7 Inducers (strong) Cytochrome P-450 CYP3A7 Inducers (weak) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Gynecological Antiinfectives and Antiseptics Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Imidazole and Triazole Derivatives Imidazole Derivatives Imidazoles OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates OATP1B3 inducers P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Steroid Synthesis Inhibitors Stomatological Preparations
ATC-Code	D01AC01 A01AB18 G01AF02 G01AF20
CAS number	23593-75-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Cytochrome P450 51	MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPL...	unknown	antagonist,inhibitor
Intermediate conductance calcium-activated potassium channel protein 4	MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFG...	unknown	inhibitor
Ergosterol	-	unknown	inhibitor
Nuclear receptor subfamily 1 group I member 2	MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATG...	unknown	activator
Hydroxycarboxylic acid receptor 2	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALW...	unknown	partial agonist
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inhibitor,inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inhibitor,inducer
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	inhibitor
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inhibitor
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inhibitor
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	inhibitor
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	inducer
P-glycoprotein 1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	inhibitor,inducer
Bile salt export pump	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQL...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B1	MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKS...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B3	MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKI...	unknown	inducer
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682