FID

(2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE

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is present as a standalone ligand in 11 entries

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Chemical Component Summary
Name	(2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE
Synonyms	FIDARESTAT
Identifiers	(2S,4S)-6-fluoro-2',5'-dioxo-spiro[chroman-4,4'-imidazolidine]-2-carboxamide
Formula	C₁₂ H₁₀ F N₃ O₄
Molecular Weight	279.224
Type	NON-POLYMER
Isomeric SMILES	c1cc2c(cc1F)[C@@]3(C[C@H](O2)C(=O)N)C(=O)NC(=O)N3
InChI	InChI=1S/C12H10FN3O4/c13-5-1-2-7-6(3-5)12(4-8(20-7)9(14)17)10(18)15-11(19)16-12/h1-3,8H,4H2,(H2,14,17)(H2,15,16,18,19)/t8-,12-/m0/s1
InChIKey	WAAPEIZFCHNLKK-UFBFGSQYSA-N

Chemical Details
Formal Charge	0
Atom Count	30
Chiral Atom Count	2
Bond Count	32
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB02021
Name	Fidarestat
Groups	experimental
Synonyms	Fidarestat (S,S)-fidarestat Aldos
Categories	Aldehyde Reductase, antagonists & inhibitors Imidazoles
CAS number	136087-85-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Aldo-keto reductase family 1 member B10	MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQ...	unknown	inhibitor
Aldose reductase	MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQ...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682