FIL

(1E)-1-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]ETHANONE O-(AMINOCARBONYL)OXIME

Created:	2004-11-17
Last modified:	2020-06-05

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1 entries where FIL is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	41
Chiral Atom Count	0
Bond Count	42
Aromatic Bond Count	6

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Chemical Component Summary
Name	(1E)-1-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]ETHANONE O-(AMINOCARBONYL)OXIME
Synonyms	FILAMINAST
Systematic Name (OpenEye OEToolkits)	[1-(3-cyclopentyloxy-4-methoxy-phenyl)ethylideneamino] carbamate
Formula	C₁₅ H₂₀ N₂ O₄
Molecular Weight	292.33
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	CACTVS	3.341	COc1ccc(cc1OC2CCCC2)C(C)=NOC(N)=O
SMILES	OpenEye OEToolkits	1.5.0	CC(=NOC(=O)N)c1ccc(c(c1)OC2CCCC2)OC
Canonical SMILES	CACTVS	3.341	COc1ccc(cc1OC2CCCC2)C(/C)=N/OC(N)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C/C(=N\OC(=O)N)/c1ccc(c(c1)OC2CCCC2)OC
InChI	InChI	1.03	InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)/b17-10+
InChIKey	InChI	1.03	STTRYQAGHGJXJJ-LICLKQGHSA-N

Drug Info: DrugBank

DrugBank ID	DB02660
Name	Filaminast
Groups	experimental
Description	Filaminast is a phosphodiesterase 4 inhibitor (PDE4 inhibitor). As such, has potential in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Synonyms	Filaminast
Categories	Amines Hydroxylamines
CAS number	141184-34-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNL...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682