FLR

(2R)-2-(3-fluoro-4-phenyl-phenyl)propanoic acid

Created:	2011-03-29
Last modified:	2020-06-05

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3 entries where FLR is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	31
Chiral Atom Count	1
Bond Count	32
Aromatic Bond Count	13

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Chemical Component Summary
Name	(2R)-2-(3-fluoro-4-phenyl-phenyl)propanoic acid
Synonyms	Flurbirprofen, R-form
Systematic Name (OpenEye OEToolkits)	(2R)-2-(3-fluoro-4-phenyl-phenyl)propanoic acid
Formula	C₁₅ H₁₃ F O₂
Molecular Weight	244.261
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	CACTVS	3.370	C[CH](C(O)=O)c1ccc(c(F)c1)c2ccccc2
SMILES	OpenEye OEToolkits	1.7.0	CC(c1ccc(c(c1)F)c2ccccc2)C(=O)O
Canonical SMILES	CACTVS	3.370	C[C@@H](C(O)=O)c1ccc(c(F)c1)c2ccccc2
Canonical SMILES	OpenEye OEToolkits	1.7.0	C[C@H](c1ccc(c(c1)F)c2ccccc2)C(=O)O
InChI	InChI	1.03	InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1
InChIKey	InChI	1.03	SYTBZMRGLBWNTM-SNVBAGLBSA-N

Drug Info: DrugBank

DrugBank ID	DB05289
Name	Tarenflurbil
Groups	investigational
Description	Tarenflurbil is an investigational drug that was studied in patients with mild Alzheimer's disease. It is a selective amyloid lowering agent (SALA) that reduces levels of the toxic peptide amyloid beta 42 (Aβ42) in cultured human cells and in animal models. Aβ42 is the primary initiator of neurotoxicity and amyloid plaque development in the brains of Alzheimer's disease patients. In June 2008 development of the drug for Alzheimer's disease was discontinued. Tarenflurbil has also been used in trials studying the treatment of Prostate Cancer.
Synonyms	(R)-2-fluoro-α-methyl(1,1'-biphenyl)-4-acetic acid Tarenflurbil (2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid (−)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid (R)-flurbiprofen
Indication	Investigated for use/treatment in alzheimer's disease and prostate cancer.
Categories	Acids, Acyclic Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Antirheumatic Agents Benzene Derivatives Biphenyl Compounds Central Nervous System Agents Cyclooxygenase Inhibitors Enzyme Inhibitors Gamma Secretase Inhibitors and Modulators Peripheral Nervous System Agents Propionates Sensory System Agents
CAS number	51543-40-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
NF-kappa-B essential modulator	MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPET...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682