GCP

PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER

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is present as a standalone ligand in 152 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 7 entries

is present in a polymer sequence 2 entries

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Chemical Component Summary
Name	PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
Identifiers	[[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]methylphosphonic acid
Formula	C₁₁ H₁₈ N₅ O₁₃ P₃
Molecular Weight	521.208
Type	NON-POLYMER
Isomeric SMILES	c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@@](=O)(CP(=O)(O)O)O)O)O)N=C(NC2=O)N
InChI	InChI=1S/C11H18N5O13P3/c12-11-14-8-5(9(19)15-11)13-2-16(8)10-7(18)6(17)4(28-10)1-27-32(25,26)29-31(23,24)3-30(20,21)22/h2,4,6-7,10,17-18H,1,3H2,(H,23,24)(H,25,26)(H2,20,21,22)(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1
InChIKey	PHBDHXOBFUBCJD-KQYNXXCUSA-N

Chemical Details
Formal Charge	0
Atom Count	50
Chiral Atom Count	6
Bond Count	52
Aromatic Bond Count	10

Drug Info: DrugBank

DrugBank ID	DB03725
Name	5'-Guanylylmethylenebisphosphonate
Groups	experimental
Synonyms	GppCp guanosine 5'-[beta,gamma-methylene]triphosphate 5'-Guanylylmethylenebisphosphonate 5'-Guanylylmethylenediphosphonate 5'-Guanosyl-methylene-triphosphate
Categories	Anti-Infective Agents Antiviral Agents Guanine Nucleotides Heterocyclic Compounds, Fused-Ring Nucleic Acids, Nucleotides, and Nucleosides Nucleotides Purine Nucleotides Purines Ribonucleotides
CAS number	13912-93-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	MPPQLQNGLNLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSE...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682