A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine with the chiral centers both located on the cylopropane ring. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).
Synonyms
Tranilcipromina
trans-2-phenylcyclopropylamine
Tranylcypromin
Racemic Tranylcypromine
trans-DL-2-Phenylcyclopropylamine
(±)-trans-2-phenylcyclopropylamine
Tranylcypromine sulfate
Tranylcypromine
(1R*,2S*)-2-phenylcyclopropan-1-amine
Tranylcyprominum
Transamine
dl-tranylcypromine
Brand Names
M-tranylcypromine
Parnate
Tranylcypromine
Tranylcypromine Sulfate
Indication
For the treatment of major depressive episode without melancholia.
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
