HSM

HISTAMINE

Find entries where: HSM

is present as a standalone ligand in 42 entries

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Chemical Component Summary
Name	HISTAMINE
Identifiers	2-(1H-imidazol-4-yl)ethanamine
Formula	C₅ H₉ N₃
Molecular Weight	111.145
Type	NON-POLYMER
Isomeric SMILES	c1c(nc[nH]1)CCN
InChI	InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
InChIKey	NTYJJOPFIAHURM-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	17
Chiral Atom Count	0
Bond Count	17
Aromatic Bond Count	5

Drug Info: DrugBank

DrugBank ID	DB05381
Name	Histamine
Groups	approved investigational
Description	A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Synonyms	beta-aminoethylimidazole Histamine phosphate 4-imidazoleethylamine Histamine Histamine dihydrochloride 1H-Imidazole-4-ethanamine 2-(4-imidazolyl)ethylamine beta-aminoethylglyoxaline 5-imidazoleethylamine
Brand Names	Simanix Histamine DHCl 0.10 Percent and Menthol 2 Percent Arthritis Pain Relief Cream Ceplene BAKERS BEST Arthritis Pain Relief Cream with Hemp and Lavender MUSCLESHOK Back Pain Arthrocare Lotion Bakers Best Arthritis Pain Relief Pain Relieving Arthritis Alo Therapeutic Massage ActivOn Ultra Strength Arthritis Mancore Muscle Mend Roll-ON Pain Reliever Glucosamine Cream EXTRA STRENGTH REVIVE SCIENCE Natural Hemp Pain Relief Rub Hand and Wrist Pain Cream Histamine Phosphate Injection USP Liq Sc Raging Kakapo Pain Relieve Rematex Australian Dream Back Pain DR. MIKES Ponos Pain Relief Cream Roll-On PainMD Max Camphomex Minted Leaf Odorless Pain Relief Arthritis Pain Relief MINTED LEAF Odorless Histamine DHCl Pain Relief and Hemp Extract TerraFreeze Pain Relief Arthritis Relief Positive Skin Test Control - Histamine Md Science Cannabigerol ROPANA Pain Relief Cream Walgreens Arthritis Pain Relief Cream Australian Dream Pain Relieving Arthritis Histamine Phosphate Injection USP, 1mg/ml Positive Skin Test Control-histamine Bakers Best Arthritis Pain Relief with Hemp Seed CVS Arthritis Pain Relief Midalgan Alo Therapeutic Massage Pain Relieving Royal Labs Hemp Recover Ponos Natural Pain Relief Md Science Cannabidiol Abee Med Dr. Freds MIRACLE RUB Histatrol MUSCLESHOK Sport AMINO ACTIVE Topical Analgesic Cream Histamine DHCl 0.10 Percent Australian Dream Hand and Wrist Pain HAVASU HEMP Soothing Pain Relief Rub Australian Dream Carpal Tunnel Pain Histamine Positive Skin Test Control
Indication	Histamine phosphate is indicated as a diagnostic aid for the evaluation of gastric acid secretory function.
Categories	Adjuvants, Immunologic Amines Antineoplastic and Immunomodulating Agents Autacoids Biogenic Amines Biogenic Monoamines Biological Factors Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 Enzyme Inhibitors Diagnostic Agents Ethylamines Gastric Function Histamine Agents Histamine Agonists Imidazoles Inflammation Mediators Neurotransmitter Agents OCT1 substrates OCT2 Inhibitors OCT2 Substrates Other Diagnostics Tests for Gastric Secretion
ATC-Code	L03AX14 V04CG03
CAS number	51-45-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Histamine H1 receptor	MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLY...	unknown	agonist
Histamine H2 receptor	MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLR...	unknown	agonist
Histamine H3 receptor	MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVL...	unknown	agonist
Histamine H4 receptor	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRS...	unknown	agonist
Synaptic vesicular amine transporter	MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYS...	unknown
Histamine N-methyltransferase	MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDT...	unknown	substrate
Solute carrier family 22 member 2	MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHR...	unknown	substrate,inhibitor
Solute carrier family 22 member 1	MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC...	unknown
Solute carrier family 22 member 3	MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYW...	unknown	inhibitor
Solute carrier family 22 member 5	MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682