HXA

DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID

Find entries where: HXA

is present as a standalone ligand in 15 entries

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Chemical Component Summary
Name	DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID
Identifiers	(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid
Formula	C₂₂ H₃₂ O₂
Molecular Weight	328.488
Type	NON-POLYMER
Isomeric SMILES	CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(=O)O
InChI	InChI=1S/C22H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16,18-19H,2,5,8,11,14,17,20-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-
InChIKey	MBMBGCFOFBJSGT-KUBAVDMBSA-N

Chemical Details
Formal Charge	0
Atom Count	56
Chiral Atom Count	0
Bond Count	55
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB03756
Name	Doconexent
Groups	approved investigational
Description	A mixture of fish oil and primrose oil, doconexent is used as a high-docosahexaenoic acid (DHA) supplement. DHA is a 22 carbon chain with 6 cis double bonds with anti-inflammatory effects. It can be biosythesized from alpha-linolenic acid or commercially manufactured from microalgae. It is an omega-3 fatty acid and primary structural component of the human brain, cerebral cortex, skin, and retina thus plays an important role in their development and function. The amino-phospholipid DHA is found at a high concentration across several brain subcellular fractions, including nerve terminals, microsomes, synaptic vesicles, and synaptosomal plasma membranes [A19436].
Synonyms	22:6-4, 7,10,13,16,19 (4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid Doconexent DHA cervonic acid Doconexent sodium all-cis-DHA 4,7,10,13,16,19-docosahexaenoic acid Docosahexaenoic acid docosa-4,7,10,13,16,19-hexaenoic acid Docosahexanoic Acid all-cis-4,7,10,13,16,19-docosahexaenoic acid 22:6(n-3)
Brand Names	PreferaOB One Animi-3 CitraNatal Harmony Re Ob 90 DHA Natalvirt 90dha Pnv Ob DHA Ultimate OB DHA HemeNatal OB plus DHA Complete Natal DHA Vp-CH-pnv CitraNatal Essence Zatean-CH BP Vit 3 Virt-C DHA CitraNatal Medley Natelle One Nexa Select Virt-PN DHA VP CH Plus Prenate Essential Prenate DHA TL-Care DHA Docosavit Vitaphil DHA CitraNatal Harmony 3.0 Pre-Tabs DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA OB Complete Petite Protect Cardio AF Prena1 Folet DHA OBTREX DHA Combo Pack Select-OB Plus DHA Prenatal Supplement Plus DHA CitraNatal DHA Tricare Prenatal Twist-off DHA Soft Quick Dissolve Virt-Bal DHA Plus Vitafol Fe Plus Taliment Nestabs ONE PreFol-DHA Virt-Pn DHA Virt-Select PRENATAL/POSTNATAL Renate DHA VemaVite-PRx 2 with Fish-Based DHA Tricare Prenatal Compleat Premium Omega 3 WesNatal DHA Complete PreNexa premier VP CH Ultra Luvira Triveen-Duo DHA Folivane-PRx DHA Dothelle DHA Oveeza Zatean-Pn Plus Folcaps Omega-3 Vitaphil 90 DHA Foltabs Prenatal Plus DHA Taliva Pnv-OB-dha A2A Omega-3 Cavan One Nutri-Tab OB plus DHA VITAFOL Gummies natelle COMPLETE Herbalifeline Prenaissance Plus TL-Select Natalvirt Ca NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Paire OB Plus DHA Cavan Folate DHA Animi-3 with Vitamin D Rulavite DHA Triveen-PRx RNF Folcal DHA Obstetrix ONE vitaMedMD One Rx Taron-prex Prenatal Folcaps Care One WestGel DHA A2A Omega 3 TriStart DHA Multinate DHA Extra Tricare Prenatal 2-part Daily Prenatal Vitamin System Prena1 Plus WesCap-C-DHA Obstetrix DHA Combo Pack Extra-Virt Plus DHA Gesticare DHA PRENATE Enhance Folet One PreNexa Focalgin CA UltimateCare ONE NF Virt-Care One Active OB Tricare Prenatal DHA One Obtrex One Vp-pnv-dha Pnv-dha Se-Plete DHA Tendera-OB Multinate DHA VP-HEME One Vitafol-OB Plus DHA Prenatal Supplement Plus DHA WesCap-PN DHA Zatean-Pn DHA Super Omega 3 Vitafol Ultra Virt-PN Plus VirtPrex Omega-3 Iq Childrens Chewable NESTABS ABC Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA CitraNatal Assure Ultra Omega 3 Choice OB DHA Provida DHA Prenaissance Renate Se-Tan DHA OB Complete 400 Prenatal, DHA PRENATE Restore PNV-Omega Tricare Prenatal DHA One Rx Multivitamin Tricare Prenatal DHA One With Folate Focalgin 90 DHA Prenate Mini Iron Polysaccharides Folic Acid DHA vitaMedMD Rx Plus Calcium PNV PreQue 10
Indication	Used as a high-docosahexaenoic acid (DHA) oral supplement.
Categories	Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dietary Fats Dietary Fats, Unsaturated Fats Fatty Acids Fatty Acids, Omega-3 Fatty Acids, Unsaturated Fish Oils Lipids Oils
CAS number	6217-54-5

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Peroxisome proliferator-activated receptor alpha	MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFG...	unknown	activator
Peroxisome proliferator-activated receptor gamma	MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDL...	unknown	activator
Retinoic acid receptor RXR-alpha	MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSP...	unknown	activator
Retinoic acid receptor RXR-beta	MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAA...	unknown	activator
Retinoic acid receptor RXR-gamma	MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPV...	unknown	activator
Sterol regulatory element-binding protein 1	MDEPPFSEAALEQALGEPCDLDAALLTDIEDMLQLINNQDSDFPGLFDPP...	unknown	inhibitor
Myc proto-oncogene protein	MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIW...	unknown	inhibitor
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	substrate,inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682