K1S

N,N-diethyl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Created:	2018-10-25
Last modified:	2018-12-19

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3 entries where K1S is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	30
Chiral Atom Count	0
Bond Count	31
Aromatic Bond Count	10

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Chemical Component Summary
Name	N,N-diethyl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Systematic Name (OpenEye OEToolkits)	~{N},~{N}-diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Formula	C₁₀ H₁₅ N₅
Molecular Weight	205.26
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	12.01	n1c(cc(n2ncnc12)N(CC)CC)C
SMILES	CACTVS	3.385	CCN(CC)c1cc(C)nc2ncnn12
SMILES	OpenEye OEToolkits	2.0.6	CCN(CC)c1cc(nc2n1ncn2)C
Canonical SMILES	CACTVS	3.385	CCN(CC)c1cc(C)nc2ncnn12
Canonical SMILES	OpenEye OEToolkits	2.0.6	CCN(CC)c1cc(nc2n1ncn2)C
InChI	InChI	1.03	InChI=1S/C10H15N5/c1-4-14(5-2)9-6-8(3)13-10-11-7-12-15(9)10/h6-7H,4-5H2,1-3H3
InChIKey	InChI	1.03	GSNOZLZNQMLSKJ-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB09283
Name	Trapidil
Groups	experimental
Description	Trapidil, a platelet-derived growth factor antagonist, was originally developed as a vasodilator and anti-platelet agent and has been used to treat patients with ischemic coronary heart, liver, and kidney disease.
Synonyms	Trapidil
Indication	Used in the treatment of chronic stable angina [A19770].
Categories	Antiplatelet agents Cardiac Therapy Cardiovascular Agents Enzyme Inhibitors Hematologic Agents Phosphodiesterase Inhibitors Pyrimidines Triazoles Vasodilating Agents Vasodilators Used in Cardiac Diseases
ATC-Code	C01DX11
CAS number	15421-84-8

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Cyclic nucleotide phosphodiesterase	MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVV...	unknown	inhibitor
Platelet-derived growth factor receptor beta	MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTF...	unknown	antagonist

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682