MET

METHIONINE

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is present as a standalone ligand in 200 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 29 entries

is present in a polymer sequence 204,551 entries

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Chemical Component Summary
Name	METHIONINE
Identifiers	(2S)-2-amino-4-methylsulfanyl-butanoic acid
Formula	C₅ H₁₁ N O₂ S
Molecular Weight	149.211
Type	L-PEPTIDE LINKING
Isomeric SMILES	CSCC[C@@H](C(=O)O)N
InChI	InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChIKey	FFEARJCKVFRZRR-BYPYZUCNSA-N

Chemical Details
Formal Charge	0
Atom Count	20
Chiral Atom Count	1
Bond Count	19
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00134
Name	Methionine
Groups	approved nutraceutical
Description	A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals.
Synonyms	L-α-amino-γ-methylmercaptobutyric acid (S)-2-amino-4-(methylthio)butanoic acid (S)-2-amino-4-(methylthio)butyric acid M (2S)-2-amino-4-(methylsulfanyl)butanoic acid L-(−)-methionine L-a-Amino-g-methylthiobutyric acid Methionine hydrochloride Met L-Methionin (S)-methionine Methionine L-Methionine
Brand Names	4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Premasol - sulfite-free (Amino Acid) Aminosyn-PF 10% Distilpure Msm FreAmine III Travasol E Renamin (amino Acids) Injection 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose ProcalAmine 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Aminosyn Sulfite Free Travasol 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Olimel 3.3% E Aminosyn RF Injection Clinisol Primene 10%-liq IV 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn II with Electrolytes Smofkabiven Vamin N BANACOS Cica-aid Centella Peptide toner Smofkabiven Extra Nitrogen Electrolyte Free 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Periolimel 2.5% E 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Plenamine Aminosyn 5% Men's Biomultiple Vitamin and Mineral Supplement RenAmin 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Primene 10% Selenium Plus Novamine Aminosyn II 7% M In 10% Dextrose(dual Chamber) Perikabiven Olimel 5.7% E 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn RF Formula Cw-caplet Essepna 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Inhibitol - Tab Aminosyn 10% W Electrolytes Aminosyn Aminosyn II 5% Inj Olimel 4.4% Aminosyn II Aminosyn II in Dextrose HepatAmine Aminosyn II 7% With 10% Dextrose 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Travasol Amino Acid Inj 8.5% 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Smofkabiven Peripheral Aminosyn 7% Travasol Amino Acid Inj 5.5% 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II 8.5% Injection Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Olimel 4.4% E Olimel 5.7% Formula Cw 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Synthamin Aminosyn 8.5% Vamin 18 Electrolyte-free BANACOCica-aid Centella Peptide emulsion Smofkabiven Extra Nitrogen 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Aminosyn II 8.5% With 50% Dextrose Nutrineal Pd4 Derma-force Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn II In Dextrose Injection Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Primene Smofkabiven Electrolyte Free Aminosyn HF 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Kabiven 20% Prosol Hepatasol Formula Cm Travasol Inj Without Electrolytes 5.5% Aminosyn-PF Women's Biomultiple Vitamin and Mineral Supplement Aminosyn II and Dextrose Aminosyn 3.5% M ProSol NephrAmine Aminosyn II 7% Injection Clinimix FreAmine HBC Aminosyn 8.5% Injection With Electrolytes Aminosyn II 7% With 50% Dextrose Aminosyn II 10% With Electrolytes 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn-PF 7% Clinimix E TrophAmine Medi Msm (methyl Sulfonyl Methane) Olimel 7.6% Olimel 7.6% E 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25%travasol Amino Acid InJ.W.elecw.5%dex.
Indication	Used for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate.
Categories	Amino Acids Amino Acids, Essential Amino Acids, Neutral Amino Acids, Peptides, and Proteins Amino Acids, Sulfur Antidotes Dietary Supplements Proteinogenic Amino Acids Sulfur Compounds Supplements
ATC-Code	V03AB26
CAS number	63-68-3

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Methionine synthase reductase	MGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEIC...	unknown	product of
Methionine synthase	MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEH...	unknown	product of
Methionine aminopeptidase 2	MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSA...	unknown	product of
Betaine--homocysteine S-methyltransferase 1	MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAV...	unknown	product of
S-methylmethionine--homocysteine S-methyltransferase BHMT2	MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVI...	unknown	product of
S-adenosylmethionine synthase isoform type-2	MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDP...	unknown	substrate
Methionine-R-sulfoxide reductase B2, mitochondrial	MARLLWLLRGLTLGTAPRRAVRGQAGGGGPGTGPGLGEAGSLATCELPLA...	unknown	substrate
S-adenosylmethionine synthase isoform type-1	MNGPVDGLCDHSLSEGVFMFTSESVGEGHPDKICDQISDAVLDAHLKQDP...	unknown	substrate
Methionine-R-sulfoxide reductase B1	MSFCSFFGGEVFQNHFEPGVYVCAKCGYELFSSRSKYAHSSPWPAFTETI...	unknown	substrate
Mitochondrial peptide methionine sulfoxide reductase	MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAAKH...	unknown	substrate
Methionine--tRNA ligase, cytoplasmic	MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPV...	unknown	substrate
Methionine--tRNA ligase, mitochondrial	MLRTSVLRLLGRTGASRLSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTP...	unknown	substrate
Methionine adenosyltransferase 2 subunit beta	MVGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQ...	unknown	substrate
S-methylmethionine--homocysteine S-methyltransferase BHMT2	MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVI...	unknown	product of
Glutamine synthetase	MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSE...	unknown	inhibitor
Methylenetetrahydrofolate reductase	MVNEARGNSSLNPCLEGSASSGSESSKDSSRCSTPGLDPERHERLREKMR...	unknown	inhibitor
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	6992087, 6137
ChEMBL	CHEMBL42336
ChEBI	CHEBI:57844, CHEBI:16643
CCDC/CSD	METHCL01, BANPUC, WOYVIP, URODIP03, URODIP02, CONZIO01, VUQNAY, POVYOP, DLMETA08, DLMETA05, URODIP, FITLID, MOCXUX, METHCL, YUDDIM, LUDHEX, BERQIY, YIGMEI, FAPMAL, FAPMEP, VUQNAY01, BERNIV, FONJAU, ZATNUH, ZATJUD, ZATNOB, ZATJOX, DLMETA12, ZATMOA, ZATLUF
COD	2240074, 2205625, 7212710, 2008948

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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MET

METHIONINE

Chemical Component Summary

Chemical Details

Drug Info: DrugBank

Drug Targets

Related Resource References