PHE

PHENYLALANINE

Find entries where: PHE

is present as a standalone ligand in 107 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 63 entries

is present in a polymer sequence 219,034 entries

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Chemical Component Summary
Name	PHENYLALANINE
Identifiers	(2S)-2-amino-3-phenyl-propanoic acid
Formula	C₉ H₁₁ N O₂
Molecular Weight	165.189
Type	L-PEPTIDE LINKING
Isomeric SMILES	c1ccc(cc1)C[C@@H](C(=O)O)N
InChI	InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
InChIKey	COLNVLDHVKWLRT-QMMMGPOBSA-N

Chemical Details
Formal Charge	0
Atom Count	23
Chiral Atom Count	1
Bond Count	23
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB00120
Name	Phenylalanine
Groups	approved investigational nutraceutical
Description	Phenylalanine is an essential aromatic amino acid that is a precursor of melanin, [dopamine], [noradrenalin] (norepinephrine), and [thyroxine].
Synonyms	Phenylalanine hydrochloride 3-phenyl-L-alanine Phenylalanine F Phenylalanine sodium Phe Phenylalaninum Fenilalanina L-Phenylalanine β-phenyl-L-alanine (S)-alpha-Amino-beta-phenylpropionic acid (S)-2-Amino-3-phenylpropionic acid beta-Phenyl-L-alanine
Brand Names	4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Premasol - sulfite-free (Amino Acid) Aminosyn-PF 10% FreAmine III Travasol E Renamin (amino Acids) Injection 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose ProcalAmine 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Aminosyn Sulfite Free Travasol 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Olimel 3.3% E Aminosyn RF Injection Clinisol Primene 10%-liq IV 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn II with Electrolytes Smofkabiven Vamin N Smofkabiven Extra Nitrogen Electrolyte Free 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Periolimel 2.5% E 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Plenamine Aminosyn 5% RenAmin 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Primene 10% Novamine Aminosyn II 7% M In 10% Dextrose(dual Chamber) Perikabiven Olimel 5.7% E 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn RF Essepna 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn 10% W Electrolytes Aminosyn Aminosyn II 5% Inj Olimel 4.4% Aminosyn II Aminosyn II in Dextrose HepatAmine Aminosyn II 7% With 10% Dextrose 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Travasol Amino Acid Inj 8.5% 8.5% Freamine III 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Smofkabiven Peripheral Aminosyn 7% Travasol Amino Acid Inj 5.5% 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II 8.5% Injection Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Olimel 4.4% E Olimel 5.7% Nephramine Liq IV 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Synthamin Aminosyn 8.5% Vamin 18 Electrolyte-free Smofkabiven Extra Nitrogen 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Aminosyn II 8.5% With 50% Dextrose Nutrineal Pd4 Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn II In Dextrose Injection Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Primene Smofkabiven Electrolyte Free Aminosyn HF 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Travasol Inj Without Electrolytes 8.5% Kabiven 20% Prosol Hepatasol Travasol Inj Without Electrolytes 5.5% Aminosyn-PF Aminosyn II and Dextrose Aminosyn 3.5% M ProSol NephrAmine Aminosyn II 7% Injection Clinimix FreAmine HBC Aminosyn 8.5% Injection With Electrolytes Aminosyn II 7% With 50% Dextrose Aminosyn II 10% With Electrolytes 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn-PF 7% Clinimix E TrophAmine Olimel 7.6% Olimel 7.6% E 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25%travasol Amino Acid InJ.W.elecw.5%dex.
Indication	L-phenylalanine may be helpful in some with depression. It may also be useful in the treatment of vitiligo. There is some evidence that L-phenylalanine may exacerbate tardive dyskinesia in some schizophrenic patients and in some who have used neuroleptic drugs.
Categories	Amino Acids Amino Acids, Aromatic Amino Acids, Cyclic Amino Acids, Essential Amino Acids, Peptides, and Proteins Dietary Supplements Immunosuppressive Agents Myelosuppressive Agents Proteinogenic Amino Acids Supplements
CAS number	63-91-2

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Tyrosine aminotransferase	MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAK...	unknown
Large neutral amino acids transporter small subunit 2	MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIV...	unknown
Phenylalanine--tRNA ligase alpha subunit	MADGQVAELLLRRLEASDGGLDSAELAAELGMEHQAVVGAVKSLQALGEV...	unknown
Phenylalanine-4-hydroxylase	MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAK...	unknown
Phenylalanine--tRNA ligase, mitochondrial	MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSV...	unknown
Phenylalanine--tRNA ligase beta subunit	MPTVSVKRDLLFQALGRTYTDEEFDELCFEFGLELDEITSEKEIISKEQG...	unknown
Tyrosine 3-monooxygenase	MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTA...	unknown	binder
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	6140, 6925665
ChEMBL	CHEMBL301523
ChEBI	CHEBI:17295, CHEBI:58095
CCDC/CSD	EDAXIQ02, EDAXIQ05, EDAXIQ06, QURQUP, EDAXIQ, NONZUL, EDAXIQ03, OJEPEY, BEZPAZ, IREKAR, PAXXUJ, RALRUS, GUQCAY, JOTKIM01, VAGVIJ, REPFUN, HUHSOS, JOTKIM, LAGDIG, CADLOK, FETNEY, CADLOK01, NALYEH, YAMVIS, MIFRIC, JAXZIS, IZAQUV, PHALNC01, EQUYEX
COD	2202945, 2200004, 4517356

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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PHE

PHENYLALANINE

Chemical Component Summary

Chemical Details

Drug Info: DrugBank

Drug Targets

Related Resource References