ZWY

17-oxoandrost-5-en-3beta-yl hydrogen sulfate

Find entries where: ZWY

is present as a standalone ligand in 6 entries

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Chemical Component Summary
Name	17-oxoandrost-5-en-3beta-yl hydrogen sulfate
Synonyms	Dehydroepiandrosterone sulfate; DHEA sulfate; DHEA-S
Identifiers	[(3~{S},8~{R},9~{S},10~{R},13~{S},14~{S})-10,13-dimethyl-17-oxidanylidene-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] hydrogen sulfate
Formula	C₁₉ H₂₈ O₅ S
Molecular Weight	368.488
Type	NON-POLYMER
Isomeric SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CC=C4[C@@]3(CC[C@@H](C4)OS(=O)(=O)O)C
InChI	InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/t13-,14-,15-,16-,18-,19-/m0/s1
InChIKey	CZWCKYRVOZZJNM-USOAJAOKSA-N

Chemical Details
Formal Charge	0
Atom Count	53
Chiral Atom Count	6
Bond Count	56
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB05804
Name	Prasterone sulfate
Groups	investigational
Description	DHEA sulfate is the major steroid of the fetal adrenal. DHEA-S is the principal adrenal androgen and is secreted together with cortisol under the control of ACTH and prolactin. DHEA-S is elevated with hyperprolactinemia.
Synonyms	Prasterone sodium sulfate anhydrous Dehydroepiandrosterone sulphate DHEA-S Prasterone sulphate Dehydroepiandrosterone sulfate Dehydroepiandrosterone monosulfate Dehydroepiandrosterone 3-sulfate (3-beta)-3-(Sulfooxy)androst-5-en-17-one Prasterone sulfate DHEA sulfate 17-Ketoandrost-5-en-3beta-yl sulfate Androst-5-en-17-on-3beta-yl sulfuric acid 17-oxoandrost-5-en-3β-yl hydrogen sulphate 3beta-Hydroxyandrost-5-en-17-one 3-sulfate 3-O-Sulfodehydroepiandrosterone DHEA sulphate Dehydroisoandrosterone sulfate Dehydroisoandrosterone-3-sulfate
Indication	Investigated for use/treatment in asthma and burns and burn infections.
Categories	17-Ketosteroids Adrenal Cortex Hormones Androstanes Androstenes Androstenols BSEP/ABCB11 Substrates Cytochrome P-450 CYP3A7 Substrates Dehydroepiandrosterone Fused-Ring Compounds Gonadal Hormones Gonadal Steroid Hormones Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Ketosteroids Steroids Testosterone Congeners
CAS number	651-48-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Cytochrome P450 19A1	MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGP...	unknown	inducer
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	substrate
Prostaglandin G/H synthase 2	MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFY...	unknown	inducer
Solute carrier family 22 member 8	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown
Solute carrier organic anion transporter family member 1A2	MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQ...	unknown
Solute carrier organic anion transporter family member 1B1	MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKS...	unknown
Solute carrier organic anion transporter family member 1B3	MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKI...	unknown
Solute carrier organic anion transporter family member 2B1	MGPRIGPAGEVPQVPDKETKATMGTENTPGGKASPDPQDVRPSVFHNIKL...	unknown
Solute carrier family 10 member 6	MRANCSSSSACPANSSEEELPVGLEVHGNLELVFTVVSTVMMGLLMFSLG...	unknown
Bile salt export pump	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQL...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682