4V8C

Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex with paromomycin).


Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.30 Å
  • R-Value Free: 0.237 
  • R-Value Work: 0.199 
  • R-Value Observed: 0.199 

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This is version 1.3 of the entry. See complete history


Literature

A new understanding of the decoding principle on the ribosome.

Demeshkina, N.Jenner, L.Westhof, E.Yusupov, M.Yusupova, G.

(2012) Nature 484: 256-259

  • DOI: https://doi.org/10.1038/nature10913
  • Primary Citation of Related Structures:  
    4V87, 4V8B, 4V8C, 4V8D, 4V8E, 4V8F

  • PubMed Abstract: 

    During protein synthesis, the ribosome accurately selects transfer RNAs (tRNAs) in accordance with the messenger RNA (mRNA) triplet in the decoding centre. tRNA selection is initiated by elongation factor Tu, which delivers tRNA to the aminoacyl tRNA-binding site (A site) and hydrolyses GTP upon establishing codon-anticodon interactions in the decoding centre. At the following proofreading step the ribosome re-examines the tRNA and rejects it if it does not match the A codon. It was suggested that universally conserved G530, A1492 and A1493 of 16S ribosomal RNA, critical for tRNA binding in the A site, actively monitor cognate tRNA, and that recognition of the correct codon-anticodon duplex induces an overall ribosome conformational change (domain closure). Here we propose an integrated mechanism for decoding based on six X-ray structures of the 70S ribosome determined at 3.1-3.4 Å resolution, modelling cognate or near-cognate states of the decoding centre at the proofreading step. We show that the 30S subunit undergoes an identical domain closure upon binding of either cognate or near-cognate tRNA. This conformational change of the 30S subunit forms a decoding centre that constrains the mRNA in such a way that the first two nucleotides of the A codon are limited to form Watson-Crick base pairs. When U·G and G·U mismatches, generally considered to form wobble base pairs, are at the first or second codon-anticodon position, the decoding centre forces this pair to adopt the geometry close to that of a canonical C·G pair. This by itself, or with distortions in the codon-anticodon mini-helix and the anticodon loop, causes the near-cognate tRNA to dissociate from the ribosome.


  • Organizational Affiliation

    Département de Biologie et de Génomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch 67400, France.


Macromolecules

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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L2C [auth AD],
GA [auth BD]
276Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 4
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L3D [auth AE],
HA [auth BE]
206Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 5
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L4E [auth AF],
IA [auth BF]
210Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 6
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L5F [auth AG],
JA [auth BG]
182Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 7
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L6G [auth AH],
KA [auth BH]
180Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 8
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L9H [auth AK],
LA [auth BK]
148Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 9
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L13I [auth AM],
MA [auth BM]
140Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 10
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L14J [auth AN],
NA [auth BN]
122Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 11
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L15K [auth AO],
OA [auth BO]
150Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 12
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L16L [auth AP],
PA [auth BP]
141Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 13
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L17M [auth A0],
QA [auth B0]
118Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 14
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L18N [auth AQ],
RA [auth BQ]
112Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 15
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L19O [auth AR],
SA [auth BR]
146Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 16
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L20P [auth A1],
TA [auth B1]
118Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 17
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L21Q [auth A2],
UA [auth B2]
101Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 18
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L22R [auth AS],
VA [auth BS]
113Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 19
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L23S [auth AT],
WA [auth BT]
96Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 20
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L24T [auth AU],
XA [auth BU]
110Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 21
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L25U [auth AV],
YA [auth BV]
206Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 22
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L27V [auth A3],
ZA [auth B3]
85Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 23
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L28AB [auth BZ],
W [auth AZ]
98Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 24
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L29BB [auth BW],
X [auth AW]
72Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 25
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L30CB [auth BX],
Y [auth AX]
60Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 26
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L31DB [auth B4],
Z [auth A4]
71Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 27
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L32AA [auth A5],
EB [auth B5]
60Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 28
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L33BA [auth A6],
FB [auth B6]
54Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 29
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L34CA [auth A7],
GB [auth B7]
49Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 30
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L35DA [auth A8],
HB [auth B8]
65Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 32
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S2IC [auth DE],
JB [auth CE]
256Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 33
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S3JC [auth DF],
KB [auth CF]
239Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 34
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S4KC [auth DG],
LB [auth CG]
208Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 35
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S5LC [auth DH],
MB [auth CH]
162Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 36
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S6MC [auth DI],
NB [auth CI]
101Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 37
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S7NC [auth DJ],
OB [auth CJ]
156Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 38
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S8OC [auth DK],
PB [auth CK]
138Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 39
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S9PC [auth DL],
QB [auth CL]
128Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 40
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S10QC [auth DM],
RB [auth CM]
105Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 41
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S11RC [auth DN],
SB [auth CN]
129Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 42
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S12SC [auth DO],
TB [auth CO]
132Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 43
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S13TC [auth DP],
UB [auth CP]
126Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 44
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S14UC [auth DQ],
VB [auth CQ]
61Thermus thermophilus HB8Mutation(s): 0 
Entity Groups  
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Entity ID: 45
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S15VC [auth DR],
WB [auth CR]
89Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SJ76 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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UniProt GroupQ5SJ76
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Entity ID: 46
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S16WC [auth DS],
XB [auth CS]
88Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SJH3 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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UniProt GroupQ5SJH3
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Entity ID: 47
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S17XC [auth DT],
YB [auth CT]
105Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 48
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S18YC [auth DU],
ZB [auth CU]
88Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SLQ0 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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UniProt GroupQ5SLQ0
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Entity ID: 49
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S19AC [auth CV],
ZC [auth DV]
93Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SHP2 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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UniProt GroupQ5SHP2
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Entity ID: 50
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN S20AD [auth DW],
BC [auth CW]
106Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for P80380 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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UniProt GroupP80380
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Entity ID: 51
MoleculeChains Sequence LengthOrganismDetailsImage
30S RIBOSOMAL PROTEIN THXBD [auth DX],
CC [auth CX]
27Escherichia coli str. K-12 substr. MDS42Mutation(s): 0 
UniProt
Find proteins for Q5SIH3 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 1
MoleculeChains LengthOrganismImage
RNA (2912-MER)A [auth AA],
EA [auth BA]
2,912Thermus thermophilus HB8
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Entity ID: 2
MoleculeChains LengthOrganismImage
5S RIBOSOMAL RNAB [auth AB],
FA [auth BB]
122Thermus thermophilus HB8
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Entity ID: 31
MoleculeChains LengthOrganismImage
16S ribosomal RNAHC [auth DA],
IB [auth CA]
1,506Thermus thermophilus HB8
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Entity ID: 52
MoleculeChains LengthOrganismImage
TRNA-LEUCD [auth DB],
DC [auth CB]
87N/A
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Entity ID: 53
MoleculeChains LengthOrganismImage
TRNA-FMETDD [auth DC],
EC [auth CC],
ED [auth DD],
FC [auth CD]
77Escherichia coli str. K-12 substr. MDS42
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Entity ID: 54
MoleculeChains LengthOrganismImage
MRNAFD [auth D1],
GC [auth C1]
10N/A
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Small Molecules
Ligands 3 Unique
IDChains Name / Formula / InChI Key2D Diagram3D Interactions
PAR
Query on PAR

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CQB [auth DA],
IHB [auth CA]
PAROMOMYCIN
C23 H45 N5 O14
UOZODPSAJZTQNH-LSWIJEOBSA-N
ZN
Query on ZN

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FQB [auth DG],
HQB [auth DQ],
LHB [auth CG],
QHB [auth CQ]
ZINC ION
Zn
PTFCDOFLOPIGGS-UHFFFAOYSA-N
MG
Query on MG

Download Ideal Coordinates CCD File 
AAA [auth AA]
AAB [auth CA]
ABA [auth AA]
ABB [auth CA]
ACA [auth AE]
AAA [auth AA],
AAB [auth CA],
ABA [auth AA],
ABB [auth CA],
ACA [auth AE],
ACB [auth CA],
ADA [auth BA],
ADB [auth CA],
AE [auth AA],
AEA [auth BA],
AEB [auth CA],
AF [auth AA],
AFA [auth BA],
AFB [auth CA],
AG [auth AA],
AGA [auth BA],
AGB [auth CA],
AH [auth AA],
AHA [auth BA],
AHB [auth CA],
AI [auth AA],
AIA [auth BA],
AIB [auth CC],
AJ [auth AA],
AJA [auth BA],
AJB [auth DA],
AK [auth AA],
AKA [auth BA],
AKB [auth DA],
AL [auth AA],
ALA [auth BA],
ALB [auth DA],
AM [auth AA],
AMA [auth BA],
AMB [auth DA],
AN [auth AA],
ANA [auth BA],
ANB [auth DA],
AO [auth AA],
AOA [auth BA],
AOB [auth DA],
AP [auth AA],
APA [auth BA],
APB [auth DA],
AQ [auth AA],
AQA [auth BA],
AQB [auth DA],
AR [auth AA],
ARA [auth BA],
AS [auth AA],
ASA [auth BA],
AT [auth AA],
ATA [auth BA],
AU [auth AA],
AUA [auth BA],
AV [auth AA],
AVA [auth BA],
AW [auth AA],
AWA [auth BA],
AX [auth AA],
AXA [auth BA],
AY [auth AA],
AYA [auth B3],
AZ [auth AA],
AZA [auth CA],
BAA [auth AA],
BAB [auth CA],
BBA [auth AA],
BBB [auth CA],
BCA [auth AE],
BCB [auth CA],
BDA [auth BA],
BDB [auth CA],
BE [auth AA],
BEA [auth BA],
BEB [auth CA],
BF [auth AA],
BFA [auth BA],
BFB [auth CA],
BG [auth AA],
BGA [auth BA],
BGB [auth CA],
BH [auth AA],
BHA [auth BA],
BHB [auth CA],
BI [auth AA],
BIA [auth BA],
BIB [auth CC],
BJ [auth AA],
BJA [auth BA],
BJB [auth DA],
BK [auth AA],
BKA [auth BA],
BKB [auth DA],
BL [auth AA],
BLA [auth BA],
BLB [auth DA],
BM [auth AA],
BMA [auth BA],
BMB [auth DA],
BN [auth AA],
BNA [auth BA],
BNB [auth DA],
BO [auth AA],
BOA [auth BA],
BOB [auth DA],
BP [auth AA],
BPA [auth BA],
BPB [auth DA],
BQ [auth AA],
BQA [auth BA],
BQB [auth DA],
BR [auth AA],
BRA [auth BA],
BS [auth AA],
BSA [auth BA],
BT [auth AA],
BTA [auth BA],
BU [auth AA],
BUA [auth BA],
BV [auth AA],
BVA [auth BA],
BW [auth AA],
BWA [auth BA],
BX [auth AA],
BXA [auth BA],
BY [auth AA],
BYA [auth B5],
BZ [auth AA],
BZA [auth CA],
CAA [auth AA],
CAB [auth CA],
CBA [auth AA],
CBB [auth CA],
CCA [auth AE],
CCB [auth CA],
CDA [auth BA],
CDB [auth CA],
CE [auth AA],
CEA [auth BA],
CEB [auth CA],
CF [auth AA],
CFA [auth BA],
CFB [auth CA],
CG [auth AA],
CGA [auth BA],
CGB [auth CA],
CH [auth AA],
CHA [auth BA],
CHB [auth CA],
CI [auth AA],
CIA [auth BA],
CIB [auth CC],
CJ [auth AA],
CJA [auth BA],
CJB [auth DA],
CK [auth AA],
CKA [auth BA],
CKB [auth DA],
CL [auth AA],
CLA [auth BA],
CLB [auth DA],
CM [auth AA],
CMA [auth BA],
CMB [auth DA],
CN [auth AA],
CNA [auth BA],
CNB [auth DA],
CO [auth AA],
COA [auth BA],
COB [auth DA],
CP [auth AA],
CPA [auth BA],
CPB [auth DA],
CQ [auth AA],
CQA [auth BA],
CR [auth AA],
CRA [auth BA],
CS [auth AA],
CSA [auth BA],
CT [auth AA],
CTA [auth BA],
CU [auth AA],
CUA [auth BA],
CV [auth AA],
CVA [auth BA],
CW [auth AA],
CWA [auth BA],
CX [auth AA],
CXA [auth BA],
CY [auth AA],
CYA [auth CA],
CZ [auth AA],
CZA [auth CA],
DAA [auth AA],
DAB [auth CA],
DBA [auth AA],
DBB [auth CA],
DCA [auth AE],
DCB [auth CA],
DDA [auth BA],
DDB [auth CA],
DE [auth AA],
DEA [auth BA],
DEB [auth CA],
DF [auth AA],
DFA [auth BA],
DFB [auth CA],
DG [auth AA],
DGA [auth BA],
DGB [auth CA],
DH [auth AA],
DHA [auth BA],
DHB [auth CA],
DI [auth AA],
DIA [auth BA],
DIB [auth CC],
DJ [auth AA],
DJA [auth BA],
DJB [auth DA],
DK [auth AA],
DKA [auth BA],
DKB [auth DA],
DL [auth AA],
DLA [auth BA],
DLB [auth DA],
DM [auth AA],
DMA [auth BA],
DMB [auth DA],
DN [auth AA],
DNA [auth BA],
DNB [auth DA],
DO [auth AA],
DOA [auth BA],
DOB [auth DA],
DP [auth AA],
DPA [auth BA],
DPB [auth DA],
DQ [auth AA],
DQA [auth BA],
DQB [auth DG],
DR [auth AA],
DRA [auth BA],
DS [auth AA],
DSA [auth BA],
DT [auth AA],
DTA [auth BA],
DU [auth AA],
DUA [auth BA],
DV [auth AA],
DVA [auth BA],
DW [auth AA],
DWA [auth BA],
DX [auth AA],
DXA [auth BB],
DY [auth AA],
DYA [auth CA],
DZ [auth AA],
DZA [auth CA],
EAA [auth AA],
EAB [auth CA],
EBA [auth AA],
EBB [auth CA],
ECA [auth AF],
ECB [auth CA],
EDA [auth BA],
EDB [auth CA],
EE [auth AA],
EEA [auth BA],
EEB [auth CA],
EF [auth AA],
EFA [auth BA],
EFB [auth CA],
EG [auth AA],
EGA [auth BA],
EGB [auth CA],
EH [auth AA],
EHA [auth BA],
EHB [auth CA],
EI [auth AA],
EIA [auth BA],
EIB [auth CD],
EJ [auth AA],
EJA [auth BA],
EJB [auth DA],
EK [auth AA],
EKA [auth BA],
EKB [auth DA],
EL [auth AA],
ELA [auth BA],
ELB [auth DA],
EM [auth AA],
EMA [auth BA],
EMB [auth DA],
EN [auth AA],
ENA [auth BA],
ENB [auth DA],
EO [auth AA],
EOA [auth BA],
EOB [auth DA],
EP [auth AA],
EPA [auth BA],
EPB [auth DA],
EQ [auth AA],
EQA [auth BA],
EQB [auth DG],
ER [auth AA],
ERA [auth BA],
ES [auth AA],
ESA [auth BA],
ET [auth AA],
ETA [auth BA],
EU [auth AA],
EUA [auth BA],
EV [auth AA],
EVA [auth BA],
EW [auth AA],
EWA [auth BA],
EX [auth AA],
EXA [auth BB],
EY [auth AA],
EYA [auth CA],
EZ [auth AA],
EZA [auth CA],
FAA [auth AA],
FAB [auth CA],
FBA [auth AA],
FBB [auth CA],
FCA [auth AF],
FCB [auth CA],
FDA [auth BA],
FDB [auth CA],
FE [auth AA],
FEA [auth BA],
FEB [auth CA],
FF [auth AA],
FFA [auth BA],
FFB [auth CA],
FG [auth AA],
FGA [auth BA],
FGB [auth CA],
FH [auth AA],
FHA [auth BA],
FHB [auth CA],
FI [auth AA],
FIA [auth BA],
FIB [auth C1],
FJ [auth AA],
FJA [auth BA],
FJB [auth DA],
FK [auth AA],
FKA [auth BA],
FKB [auth DA],
FL [auth AA],
FLA [auth BA],
FLB [auth DA],
FM [auth AA],
FMA [auth BA],
FMB [auth DA],
FN [auth AA],
FNA [auth BA],
FNB [auth DA],
FO [auth AA],
FOA [auth BA],
FOB [auth DA],
FP [auth AA],
FPA [auth BA],
FPB [auth DA],
FQ [auth AA],
FQA [auth BA],
FR [auth AA],
FRA [auth BA],
FS [auth AA],
FSA [auth BA],
FT [auth AA],
FTA [auth BA],
FU [auth AA],
FUA [auth BA],
FV [auth AA],
FVA [auth BA],
FW [auth AA],
FWA [auth BA],
FX [auth AA],
FXA [auth BB],
FY [auth AA],
FYA [auth CA],
FZ [auth AA],
FZA [auth CA],
GAA [auth AA],
GAB [auth CA],
GBA [auth AA],
GBB [auth CA],
GCA [auth AF],
GCB [auth CA],
GD [auth AA],
GDA [auth BA],
GDB [auth CA],
GE [auth AA],
GEA [auth BA],
GEB [auth CA],
GF [auth AA],
GFA [auth BA],
GFB [auth CA],
GG [auth AA],
GGA [auth BA],
GGB [auth CA],
GH [auth AA],
GHA [auth BA],
GHB [auth CA],
GI [auth AA],
GIA [auth BA],
GIB [auth DA],
GJ [auth AA],
GJA [auth BA],
GJB [auth DA],
GK [auth AA],
GKA [auth BA],
GKB [auth DA],
GL [auth AA],
GLA [auth BA],
GLB [auth DA],
GM [auth AA],
GMA [auth BA],
GMB [auth DA],
GN [auth AA],
GNA [auth BA],
GNB [auth DA],
GO [auth AA],
GOA [auth BA],
GOB [auth DA],
GP [auth AA],
GPA [auth BA],
GPB [auth DA],
GQ [auth AA],
GQA [auth BA],
GQB [auth DH],
GR [auth AA],
GRA [auth BA],
GS [auth AA],
GSA [auth BA],
GT [auth AA],
GTA [auth BA],
GU [auth AA],
GUA [auth BA],
GV [auth AA],
GVA [auth BA],
GW [auth AA],
GWA [auth BA],
GX [auth AA],
GXA [auth BB],
GY [auth AA],
GYA [auth CA],
GZ [auth AA],
GZA [auth CA],
HAA [auth AA],
HAB [auth CA],
HBA [auth AA],
HBB [auth CA],
HCA [auth AO],
HCB [auth CA],
HD [auth AA],
HDA [auth BA],
HDB [auth CA],
HE [auth AA],
HEA [auth BA],
HEB [auth CA],
HF [auth AA],
HFA [auth BA],
HFB [auth CA],
HG [auth AA],
HGA [auth BA],
HGB [auth CA],
HH [auth AA],
HHA [auth BA],
HHB [auth CA],
HI [auth AA],
HIA [auth BA],
HIB [auth DA],
HJ [auth AA],
HJA [auth BA],
HJB [auth DA],
HK [auth AA],
HKA [auth BA],
HKB [auth DA],
HL [auth AA],
HLA [auth BA],
HLB [auth DA],
HM [auth AA],
HMA [auth BA],
HMB [auth DA],
HN [auth AA],
HNA [auth BA],
HNB [auth DA],
HO [auth AA],
HOA [auth BA],
HOB [auth DA],
HP [auth AA],
HPA [auth BA],
HPB [auth DA],
HQ [auth AA],
HQA [auth BA],
HR [auth AA],
HRA [auth BA],
HS [auth AA],
HSA [auth BA],
HT [auth AA],
HTA [auth BA],
HU [auth AA],
HUA [auth BA],
HV [auth AA],
HVA [auth BA],
HW [auth AA],
HWA [auth BA],
HX [auth AA],
HXA [auth BB],
HY [auth AA],
HYA [auth CA],
HZ [auth AA],
HZA [auth CA],
IAA [auth AA],
IAB [auth CA],
IBA [auth AB],
IBB [auth CA],
ICA [auth AO],
ICB [auth CA],
ID [auth AA],
IDA [auth BA],
IDB [auth CA],
IE [auth AA],
IEA [auth BA],
IEB [auth CA],
IF [auth AA],
IFA [auth BA],
IFB [auth CA],
IG [auth AA],
IGA [auth BA],
IGB [auth CA],
IH [auth AA],
IHA [auth BA],
II [auth AA],
IIA [auth BA],
IIB [auth DA],
IJ [auth AA],
IJA [auth BA],
IJB [auth DA],
IK [auth AA],
IKA [auth BA],
IKB [auth DA],
IL [auth AA],
ILA [auth BA],
ILB [auth DA],
IM [auth AA],
IMA [auth BA],
IMB [auth DA],
IN [auth AA],
INA [auth BA],
INB [auth DA],
IO [auth AA],
IOA [auth BA],
IOB [auth DA],
IP [auth AA],
IPA [auth BA],
IPB [auth DA],
IQ [auth AA],
IQA [auth BA],
IQB [auth DS],
IR [auth AA],
IRA [auth BA],
IS [auth AA],
ISA [auth BA],
IT [auth AA],
ITA [auth BA],
IU [auth AA],
IUA [auth BA],
IV [auth AA],
IVA [auth BA],
IW [auth AA],
IWA [auth BA],
IX [auth AA],
IXA [auth BB],
IY [auth AA],
IYA [auth CA],
IZ [auth AA],
IZA [auth CA],
JAA [auth AA],
JAB [auth CA],
JBA [auth AB],
JBB [auth CA],
JCA [auth AO],
JCB [auth CA],
JD [auth AA],
JDA [auth BA],
JDB [auth CA],
JE [auth AA],
JEA [auth BA],
JEB [auth CA],
JF [auth AA],
JFA [auth BA],
JFB [auth CA],
JG [auth AA],
JGA [auth BA],
JGB [auth CA],
JH [auth AA],
JHA [auth BA],
JHB [auth CG],
JI [auth AA],
JIA [auth BA],
JIB [auth DA],
JJ [auth AA],
JJA [auth BA],
JJB [auth DA],
JK [auth AA],
JKA [auth BA],
JKB [auth DA],
JL [auth AA],
JLA [auth BA],
JLB [auth DA],
JM [auth AA],
JMA [auth BA],
JMB [auth DA],
JN [auth AA],
JNA [auth BA],
JNB [auth DA],
JO [auth AA],
JOA [auth BA],
JOB [auth DA],
JP [auth AA],
JPA [auth BA],
JPB [auth DA],
JQ [auth AA],
JQA [auth BA],
JQB [auth DB],
JR [auth AA],
JRA [auth BA],
JS [auth AA],
JSA [auth BA],
JT [auth AA],
JTA [auth BA],
JU [auth AA],
JUA [auth BA],
JV [auth AA],
JVA [auth BA],
JW [auth AA],
JWA [auth BA],
JX [auth AA],
JXA [auth BB],
JY [auth AA],
JYA [auth CA],
JZ [auth AA],
JZA [auth CA],
KAA [auth AA],
KAB [auth CA],
KBA [auth AB],
KBB [auth CA],
KCA [auth A0],
KCB [auth CA],
KD [auth AA],
KDA [auth BA],
KDB [auth CA],
KE [auth AA],
KEA [auth BA],
KEB [auth CA],
KF [auth AA],
KFA [auth BA],
KFB [auth CA],
KG [auth AA],
KGA [auth BA],
KGB [auth CA],
KH [auth AA],
KHA [auth BA],
KHB [auth CG],
KI [auth AA],
KIA [auth BA],
KIB [auth DA],
KJ [auth AA],
KJA [auth BA],
KJB [auth DA],
KK [auth AA],
KKA [auth BA],
KKB [auth DA],
KL [auth AA],
KLA [auth BA],
KLB [auth DA],
KM [auth AA],
KMA [auth BA],
KMB [auth DA],
KN [auth AA],
KNA [auth BA],
KNB [auth DA],
KO [auth AA],
KOA [auth BA],
KOB [auth DA],
KP [auth AA],
KPA [auth BA],
KPB [auth DA],
KQ [auth AA],
KQA [auth BA],
KQB [auth DB],
KR [auth AA],
KRA [auth BA],
KS [auth AA],
KSA [auth BA],
KT [auth AA],
KTA [auth BA],
KU [auth AA],
KUA [auth BA],
KV [auth AA],
KVA [auth BA],
KW [auth AA],
KWA [auth BA],
KX [auth AA],
KXA [auth BB],
KY [auth AA],
KYA [auth CA],
KZ [auth AA],
KZA [auth CA],
LAA [auth AA],
LAB [auth CA],
LBA [auth AB],
LBB [auth CA],
LCA [auth A1],
LCB [auth CA],
LD [auth AA],
LDA [auth BA],
LDB [auth CA],
LE [auth AA],
LEA [auth BA],
LEB [auth CA],
LF [auth AA],
LFA [auth BA],
LFB [auth CA],
LG [auth AA],
LGA [auth BA],
LGB [auth CA],
LH [auth AA],
LHA [auth BA],
LI [auth AA],
LIA [auth BA],
LIB [auth DA],
LJ [auth AA],
LJA [auth BA],
LJB [auth DA],
LK [auth AA],
LKA [auth BA],
LKB [auth DA],
LL [auth AA],
LLA [auth BA],
LLB [auth DA],
LM [auth AA],
LMA [auth BA],
LMB [auth DA],
LN [auth AA],
LNA [auth BA],
LNB [auth DA],
LO [auth AA],
LOA [auth BA],
LOB [auth DA],
LP [auth AA],
LPA [auth BA],
LPB [auth DA],
LQ [auth AA],
LQA [auth BA],
LQB [auth DC],
LR [auth AA],
LRA [auth BA],
LS [auth AA],
LSA [auth BA],
LT [auth AA],
LTA [auth BA],
LU [auth AA],
LUA [auth BA],
LV [auth AA],
LVA [auth BA],
LW [auth AA],
LWA [auth BA],
LX [auth AA],
LXA [auth BB],
LY [auth AA],
LYA [auth CA],
LZ [auth AA],
LZA [auth CA],
MAA [auth AA],
MAB [auth CA],
MBA [auth AB],
MBB [auth CA],
MCA [auth A2],
MCB [auth CA],
MD [auth AA],
MDA [auth BA],
MDB [auth CA],
ME [auth AA],
MEA [auth BA],
MEB [auth CA],
MF [auth AA],
MFA [auth BA],
MFB [auth CA],
MG [auth AA],
MGA [auth BA],
MGB [auth CA],
MH [auth AA],
MHA [auth BA],
MHB [auth CN],
MI [auth AA],
MIA [auth BA],
MIB [auth DA],
MJ [auth AA],
MJA [auth BA],
MJB [auth DA],
MK [auth AA],
MKA [auth BA],
MKB [auth DA],
ML [auth AA],
MLA [auth BA],
MLB [auth DA],
MM [auth AA],
MMA [auth BA],
MMB [auth DA],
MN [auth AA],
MNA [auth BA],
MNB [auth DA],
MO [auth AA],
MOA [auth BA],
MOB [auth DA],
MP [auth AA],
MPA [auth BA],
MPB [auth DA],
MQ [auth AA],
MQA [auth BA],
MQB [auth DC],
MR [auth AA],
MRA [auth BA],
MS [auth AA],
MSA [auth BA],
MT [auth AA],
MTA [auth BA],
MU [auth AA],
MUA [auth BA],
MV [auth AA],
MVA [auth BA],
MW [auth AA],
MWA [auth BA],
MX [auth AA],
MXA [auth BB],
MY [auth AA],
MYA [auth CA],
MZ [auth AA],
MZA [auth CA],
NAA [auth AA],
NAB [auth CA],
NBA [auth AB],
NBB [auth CA],
NCA [auth AU],
NCB [auth CA],
ND [auth AA],
NDA [auth BA],
NDB [auth CA],
NE [auth AA],
NEA [auth BA],
NEB [auth CA],
NF [auth AA],
NFA [auth BA],
NFB [auth CA],
NG [auth AA],
NGA [auth BA],
NGB [auth CA],
NH [auth AA],
NHA [auth BA],
NHB [auth CN],
NI [auth AA],
NIA [auth BA],
NIB [auth DA],
NJ [auth AA],
NJA [auth BA],
NJB [auth DA],
NK [auth AA],
NKA [auth BA],
NKB [auth DA],
NL [auth AA],
NLA [auth BA],
NLB [auth DA],
NM [auth AA],
NMA [auth BA],
NMB [auth DA],
NN [auth AA],
NNA [auth BA],
NNB [auth DA],
NO [auth AA],
NOA [auth BA],
NOB [auth DA],
NP [auth AA],
NPA [auth BA],
NPB [auth DA],
NQ [auth AA],
NQA [auth BA],
NQB [auth DC],
NR [auth AA],
NRA [auth BA],
NS [auth AA],
NSA [auth BA],
NT [auth AA],
NTA [auth BA],
NU [auth AA],
NUA [auth BA],
NV [auth AA],
NVA [auth BA],
NW [auth AA],
NWA [auth BA],
NX [auth AA],
NXA [auth BB],
NY [auth AA],
NYA [auth CA],
NZ [auth AA],
NZA [auth CA],
OAA [auth AA],
OAB [auth CA],
OBA [auth AB],
OBB [auth CA],
OCA [auth A3],
OCB [auth CA],
OD [auth AA],
ODA [auth BA],
ODB [auth CA],
OE [auth AA],
OEA [auth BA],
OEB [auth CA],
OF [auth AA],
OFA [auth BA],
OFB [auth CA],
OG [auth AA],
OGA [auth BA],
OGB [auth CA],
OH [auth AA],
OHA [auth BA],
OHB [auth CQ],
OI [auth AA],
OIA [auth BA],
OIB [auth DA],
OJ [auth AA],
OJA [auth BA],
OJB [auth DA],
OK [auth AA],
OKA [auth BA],
OKB [auth DA],
OL [auth AA],
OLA [auth BA],
OLB [auth DA],
OM [auth AA],
OMA [auth BA],
OMB [auth DA],
ON [auth AA],
ONA [auth BA],
ONB [auth DA],
OO [auth AA],
OOA [auth BA],
OOB [auth DA],
OP [auth AA],
OPA [auth BA],
OPB [auth DA],
OQ [auth AA],
OQA [auth BA],
OQB [auth DC],
OR [auth AA],
ORA [auth BA],
OS [auth AA],
OSA [auth BA],
OT [auth AA],
OTA [auth BA],
OU [auth AA],
OUA [auth BA],
OV [auth AA],
OVA [auth BA],
OW [auth AA],
OWA [auth BA],
OX [auth AA],
OXA [auth BB],
OY [auth AA],
OYA [auth CA],
OZ [auth AA],
OZA [auth CA],
PAA [auth AA],
PAB [auth CA],
PBA [auth AB],
PBB [auth CA],
PCA [auth AZ],
PCB [auth CA],
PD [auth AA],
PDA [auth BA],
PDB [auth CA],
PE [auth AA],
PEA [auth BA],
PEB [auth CA],
PF [auth AA],
PFA [auth BA],
PFB [auth CA],
PG [auth AA],
PGA [auth BA],
PGB [auth CA],
PH [auth AA],
PHA [auth BA],
PHB [auth CQ],
PI [auth AA],
PIA [auth BA],
PIB [auth DA],
PJ [auth AA],
PJA [auth BA],
PJB [auth DA],
PK [auth AA],
PKA [auth BA],
PKB [auth DA],
PL [auth AA],
PLA [auth BA],
PLB [auth DA],
PM [auth AA],
PMA [auth BA],
PMB [auth DA],
PN [auth AA],
PNA [auth BA],
PNB [auth DA],
PO [auth AA],
POA [auth BA],
POB [auth DA],
PP [auth AA],
PPA [auth BA],
PPB [auth DA],
PQ [auth AA],
PQA [auth BA],
PQB [auth DC],
PR [auth AA],
PRA [auth BA],
PS [auth AA],
PSA [auth BA],
PT [auth AA],
PTA [auth BA],
PU [auth AA],
PUA [auth BA],
PV [auth AA],
PVA [auth BA],
PW [auth AA],
PWA [auth BA],
PX [auth AA],
PXA [auth BB],
PY [auth AA],
PYA [auth CA],
PZ [auth AA],
PZA [auth CA],
QAA [auth AA],
QAB [auth CA],
QBA [auth AB],
QBB [auth CA],
QCA [auth A5],
QCB [auth CA],
QD [auth AA],
QDA [auth BA],
QDB [auth CA],
QE [auth AA],
QEA [auth BA],
QEB [auth CA],
QF [auth AA],
QFA [auth BA],
QFB [auth CA],
QG [auth AA],
QGA [auth BA],
QGB [auth CA],
QH [auth AA],
QHA [auth BA],
QI [auth AA],
QIA [auth BA],
QIB [auth DA],
QJ [auth AA],
QJA [auth BA],
QJB [auth DA],
QK [auth AA],
QKA [auth BA],
QKB [auth DA],
QL [auth AA],
QLA [auth BA],
QLB [auth DA],
QM [auth AA],
QMA [auth BA],
QMB [auth DA],
QN [auth AA],
QNA [auth BA],
QNB [auth DA],
QO [auth AA],
QOA [auth BA],
QOB [auth DA],
QP [auth AA],
QPA [auth BA],
QPB [auth DA],
QQ [auth AA],
QQA [auth BA],
QQB [auth DC],
QR [auth AA],
QRA [auth BA],
QS [auth AA],
QSA [auth BA],
QT [auth AA],
QTA [auth BA],
QU [auth AA],
QUA [auth BA],
QV [auth AA],
QVA [auth BA],
QW [auth AA],
QWA [auth BA],
QX [auth AA],
QXA [auth BB],
QY [auth AA],
QYA [auth CA],
QZ [auth AA],
QZA [auth CA],
RAA [auth AA],
RAB [auth CA],
RBA [auth AB],
RBB [auth CA],
RCA [auth A5],
RCB [auth CA],
RD [auth AA],
RDA [auth BA],
RDB [auth CA],
RE [auth AA],
REA [auth BA],
REB [auth CA],
RF [auth AA],
RFA [auth BA],
RFB [auth CA],
RG [auth AA],
RGA [auth BA],
RGB [auth CA],
RH [auth AA],
RHA [auth BA],
RHB [auth CT],
RI [auth AA],
RIA [auth BA],
RIB [auth DA],
RJ [auth AA],
RJA [auth BA],
RJB [auth DA],
RK [auth AA],
RKA [auth BA],
RKB [auth DA],
RL [auth AA],
RLA [auth BA],
RLB [auth DA],
RM [auth AA],
RMA [auth BA],
RMB [auth DA],
RN [auth AA],
RNA [auth BA],
RNB [auth DA],
RO [auth AA],
ROA [auth BA],
ROB [auth DA],
RP [auth AA],
RPA [auth BA],
RPB [auth DA],
RQ [auth AA],
RQA [auth BA],
RQB [auth DC],
RR [auth AA],
RRA [auth BA],
RS [auth AA],
RSA [auth BA],
RT [auth AA],
RTA [auth BA],
RU [auth AA],
RUA [auth BA],
RV [auth AA],
RVA [auth BA],
RW [auth AA],
RWA [auth BA],
RX [auth AA],
RXA [auth BB],
RY [auth AA],
RYA [auth CA],
RZ [auth AA],
RZA [auth CA],
SAA [auth AA],
SAB [auth CA],
SBA [auth AB],
SBB [auth CA],
SCA [auth A6],
SCB [auth CA],
SD [auth AA],
SDA [auth BA],
SDB [auth CA],
SE [auth AA],
SEA [auth BA],
SEB [auth CA],
SF [auth AA],
SFA [auth BA],
SFB [auth CA],
SG [auth AA],
SGA [auth BA],
SGB [auth CA],
SH [auth AA],
SHA [auth BA],
SHB [auth CB],
SI [auth AA],
SIA [auth BA],
SIB [auth DA],
SJ [auth AA],
SJA [auth BA],
SJB [auth DA],
SK [auth AA],
SKA [auth BA],
SKB [auth DA],
SL [auth AA],
SLA [auth BA],
SLB [auth DA],
SM [auth AA],
SMA [auth BA],
SMB [auth DA],
SN [auth AA],
SNA [auth BA],
SNB [auth DA],
SO [auth AA],
SOA [auth BA],
SOB [auth DA],
SP [auth AA],
SPA [auth BA],
SPB [auth DA],
SQ [auth AA],
SQA [auth BA],
SQB [auth DC],
SR [auth AA],
SRA [auth BA],
SS [auth AA],
SSA [auth BA],
ST [auth AA],
STA [auth BA],
SU [auth AA],
SUA [auth BA],
SV [auth AA],
SVA [auth BA],
SW [auth AA],
SWA [auth BA],
SX [auth AA],
SXA [auth BD],
SY [auth AA],
SYA [auth CA],
SZ [auth AA],
SZA [auth CA],
TAA [auth AA],
TAB [auth CA],
TBA [auth AB],
TBB [auth CA],
TCA [auth A7],
TCB [auth CA],
TD [auth AA],
TDA [auth BA],
TDB [auth CA],
TE [auth AA],
TEA [auth BA],
TEB [auth CA],
TF [auth AA],
TFA [auth BA],
TFB [auth CA],
TG [auth AA],
TGA [auth BA],
TGB [auth CA],
TH [auth AA],
THA [auth BA],
THB [auth CB],
TI [auth AA],
TIA [auth BA],
TIB [auth DA],
TJ [auth AA],
TJA [auth BA],
TJB [auth DA],
TK [auth AA],
TKA [auth BA],
TKB [auth DA],
TL [auth AA],
TLA [auth BA],
TLB [auth DA],
TM [auth AA],
TMA [auth BA],
TMB [auth DA],
TN [auth AA],
TNA [auth BA],
TNB [auth DA],
TO [auth AA],
TOA [auth BA],
TOB [auth DA],
TP [auth AA],
TPA [auth BA],
TPB [auth DA],
TQ [auth AA],
TQA [auth BA],
TR [auth AA],
TRA [auth BA],
TS [auth AA],
TSA [auth BA],
TT [auth AA],
TTA [auth BA],
TU [auth AA],
TUA [auth BA],
TV [auth AA],
TVA [auth BA],
TW [auth AA],
TWA [auth BA],
TX [auth AA],
TXA [auth BE],
TY [auth AA],
TYA [auth CA],
TZ [auth AA],
TZA [auth CA],
UAA [auth AA],
UAB [auth CA],
UBA [auth AB],
UBB [auth CA],
UCA [auth A7],
UCB [auth CA],
UD [auth AA],
UDA [auth BA],
UDB [auth CA],
UE [auth AA],
UEA [auth BA],
UEB [auth CA],
UF [auth AA],
UFA [auth BA],
UFB [auth CA],
UG [auth AA],
UGA [auth BA],
UGB [auth CA],
UH [auth AA],
UHA [auth BA],
UHB [auth CB],
UI [auth AA],
UIA [auth BA],
UIB [auth DA],
UJ [auth AA],
UJA [auth BA],
UJB [auth DA],
UK [auth AA],
UKA [auth BA],
UKB [auth DA],
UL [auth AA],
ULA [auth BA],
ULB [auth DA],
UM [auth AA],
UMA [auth BA],
UMB [auth DA],
UN [auth AA],
UNA [auth BA],
UNB [auth DA],
UO [auth AA],
UOA [auth BA],
UOB [auth DA],
UP [auth AA],
UPA [auth BA],
UPB [auth DA],
UQ [auth AA],
UQA [auth BA],
UR [auth AA],
URA [auth BA],
US [auth AA],
USA [auth BA],
UT [auth AA],
UTA [auth BA],
UU [auth AA],
UUA [auth BA],
UV [auth AA],
UVA [auth BA],
UW [auth AA],
UWA [auth BA],
UX [auth AA],
UXA [auth BE],
UY [auth AA],
UYA [auth CA],
UZ [auth AA],
UZA [auth CA],
VAA [auth AA],
VAB [auth CA],
VBA [auth AB],
VBB [auth CA],
VCA [auth BA],
VCB [auth CA],
VD [auth AA],
VDA [auth BA],
VDB [auth CA],
VE [auth AA],
VEA [auth BA],
VEB [auth CA],
VF [auth AA],
VFA [auth BA],
VFB [auth CA],
VG [auth AA],
VGA [auth BA],
VGB [auth CA],
VH [auth AA],
VHA [auth BA],
VHB [auth CB],
VI [auth AA],
VIA [auth BA],
VIB [auth DA],
VJ [auth AA],
VJA [auth BA],
VJB [auth DA],
VK [auth AA],
VKA [auth BA],
VKB [auth DA],
VL [auth AA],
VLA [auth BA],
VLB [auth DA],
VM [auth AA],
VMA [auth BA],
VMB [auth DA],
VN [auth AA],
VNA [auth BA],
VNB [auth DA],
VO [auth AA],
VOA [auth BA],
VOB [auth DA],
VP [auth AA],
VPA [auth BA],
VPB [auth DA],
VQ [auth AA],
VQA [auth BA],
VR [auth AA],
VRA [auth BA],
VS [auth AA],
VSA [auth BA],
VT [auth AA],
VTA [auth BA],
VU [auth AA],
VUA [auth BA],
VV [auth AA],
VVA [auth BA],
VW [auth AA],
VWA [auth BA],
VX [auth AA],
VXA [auth BE],
VY [auth AA],
VYA [auth CA],
VZ [auth AA],
VZA [auth CA],
WAA [auth AA],
WAB [auth CA],
WBA [auth AB],
WBB [auth CA],
WCA [auth BA],
WCB [auth CA],
WD [auth AA],
WDA [auth BA],
WDB [auth CA],
WE [auth AA],
WEA [auth BA],
WEB [auth CA],
WF [auth AA],
WFA [auth BA],
WFB [auth CA],
WG [auth AA],
WGA [auth BA],
WGB [auth CA],
WH [auth AA],
WHA [auth BA],
WHB [auth CB],
WI [auth AA],
WIA [auth BA],
WIB [auth DA],
WJ [auth AA],
WJA [auth BA],
WJB [auth DA],
WK [auth AA],
WKA [auth BA],
WKB [auth DA],
WL [auth AA],
WLA [auth BA],
WLB [auth DA],
WM [auth AA],
WMA [auth BA],
WMB [auth DA],
WN [auth AA],
WNA [auth BA],
WNB [auth DA],
WO [auth AA],
WOA [auth BA],
WOB [auth DA],
WP [auth AA],
WPA [auth BA],
WPB [auth DA],
WQ [auth AA],
WQA [auth BA],
WR [auth AA],
WRA [auth BA],
WS [auth AA],
WSA [auth BA],
WT [auth AA],
WTA [auth BA],
WU [auth AA],
WUA [auth BA],
WV [auth AA],
WVA [auth BA],
WW [auth AA],
WWA [auth BA],
WX [auth AA],
WXA [auth BP],
WY [auth AA],
WYA [auth CA],
WZ [auth AA],
WZA [auth CA],
XAA [auth AA],
XAB [auth CA],
XBA [auth AB],
XBB [auth CA],
XCA [auth BA],
XCB [auth CA],
XD [auth AA],
XDA [auth BA],
XDB [auth CA],
XE [auth AA],
XEA [auth BA],
XEB [auth CA],
XF [auth AA],
XFA [auth BA],
XFB [auth CA],
XG [auth AA],
XGA [auth BA],
XGB [auth CA],
XH [auth AA],
XHA [auth BA],
XHB [auth CC],
XI [auth AA],
XIA [auth BA],
XIB [auth DA],
XJ [auth AA],
XJA [auth BA],
XJB [auth DA],
XK [auth AA],
XKA [auth BA],
XKB [auth DA],
XL [auth AA],
XLA [auth BA],
XLB [auth DA],
XM [auth AA],
XMA [auth BA],
XMB [auth DA],
XN [auth AA],
XNA [auth BA],
XNB [auth DA],
XO [auth AA],
XOA [auth BA],
XOB [auth DA],
XP [auth AA],
XPA [auth BA],
XPB [auth DA],
XQ [auth AA],
XQA [auth BA],
XR [auth AA],
XRA [auth BA],
XS [auth AA],
XSA [auth BA],
XT [auth AA],
XTA [auth BA],
XU [auth AA],
XUA [auth BA],
XV [auth AA],
XVA [auth BA],
XW [auth AA],
XWA [auth BA],
XX [auth AA],
XXA [auth BR],
XY [auth AA],
XYA [auth CA],
XZ [auth AA],
XZA [auth CA],
YAA [auth AA],
YAB [auth CA],
YBA [auth AB],
YBB [auth CA],
YCA [auth BA],
YCB [auth CA],
YD [auth AA],
YDA [auth BA],
YDB [auth CA],
YE [auth AA],
YEA [auth BA],
YEB [auth CA],
YF [auth AA],
YFA [auth BA],
YFB [auth CA],
YG [auth AA],
YGA [auth BA],
YGB [auth CA],
YH [auth AA],
YHA [auth BA],
YHB [auth CC],
YI [auth AA],
YIA [auth BA],
YIB [auth DA],
YJ [auth AA],
YJA [auth BA],
YJB [auth DA],
YK [auth AA],
YKA [auth BA],
YKB [auth DA],
YL [auth AA],
YLA [auth BA],
YLB [auth DA],
YM [auth AA],
YMA [auth BA],
YMB [auth DA],
YN [auth AA],
YNA [auth BA],
YNB [auth DA],
YO [auth AA],
YOA [auth BA],
YOB [auth DA],
YP [auth AA],
YPA [auth BA],
YPB [auth DA],
YQ [auth AA],
YQA [auth BA],
YR [auth AA],
YRA [auth BA],
YS [auth AA],
YSA [auth BA],
YT [auth AA],
YTA [auth BA],
YU [auth AA],
YUA [auth BA],
YV [auth AA],
YVA [auth BA],
YW [auth AA],
YWA [auth BA],
YX [auth AA],
YXA [auth BR],
YY [auth AA],
YYA [auth CA],
YZ [auth AA],
YZA [auth CA],
ZAA [auth AA],
ZAB [auth CA],
ZBA [auth AD],
ZBB [auth CA],
ZCA [auth BA],
ZCB [auth CA],
ZD [auth AA],
ZDA [auth BA],
ZDB [auth CA],
ZE [auth AA],
ZEA [auth BA],
ZEB [auth CA],
ZF [auth AA],
ZFA [auth BA],
ZFB [auth CA],
ZG [auth AA],
ZGA [auth BA],
ZGB [auth CA],
ZH [auth AA],
ZHA [auth BA],
ZHB [auth CC],
ZI [auth AA],
ZIA [auth BA],
ZIB [auth DA],
ZJ [auth AA],
ZJA [auth BA],
ZJB [auth DA],
ZK [auth AA],
ZKA [auth BA],
ZKB [auth DA],
ZL [auth AA],
ZLA [auth BA],
ZLB [auth DA],
ZM [auth AA],
ZMA [auth BA],
ZMB [auth DA],
ZN [auth AA],
ZNA [auth BA],
ZNB [auth DA],
ZO [auth AA],
ZOA [auth BA],
ZOB [auth DA],
ZP [auth AA],
ZPA [auth BA],
ZPB [auth DA],
ZQ [auth AA],
ZQA [auth BA],
ZR [auth AA],
ZRA [auth BA],
ZS [auth AA],
ZSA [auth BA],
ZT [auth AA],
ZTA [auth BA],
ZU [auth AA],
ZUA [auth BA],
ZV [auth AA],
ZVA [auth BA],
ZW [auth AA],
ZWA [auth BA],
ZX [auth AA],
ZXA [auth B1],
ZY [auth AA],
ZYA [auth CA],
ZZ [auth AA],
ZZA [auth CA]
MAGNESIUM ION
Mg
JLVVSXFLKOJNIY-UHFFFAOYSA-N
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.30 Å
  • R-Value Free: 0.237 
  • R-Value Work: 0.199 
  • R-Value Observed: 0.199 
  • Space Group: P 21 21 21
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 209.43α = 90
b = 448.15β = 90
c = 619.4γ = 90
Software Package:
Software NamePurpose
XSCALEdata scaling
PHENIXrefinement
PDB_EXTRACTdata extraction
RemDAqdata collection
PHENIXmodel building
XDSdata reduction
PHENIXphasing

Structure Validation

View Full Validation Report



Ligand Structure Quality Assessment 


Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2014-07-09
    Type: Initial release
  • Version 1.1: 2014-12-10
    Changes: Other
  • Version 1.2: 2017-11-22
    Changes: Advisory, Refinement description
  • Version 1.3: 2024-11-27
    Changes: Advisory, Data collection, Database references, Derived calculations, Structure summary