1E2T

Arylamine N-acetyltransferase (NAT) from Salmonella typhimurium

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1e2ta_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases Arylamine N-acetyltransferase Arylamine N-acetyltransferase (Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ], SCOPe (2.08)
Gd1e2tg_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases Arylamine N-acetyltransferase Arylamine N-acetyltransferase (Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ], SCOPe (2.08)
Bd1e2tb_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases Arylamine N-acetyltransferase Arylamine N-acetyltransferase (Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ], SCOPe (2.08)
Cd1e2tc_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases Arylamine N-acetyltransferase Arylamine N-acetyltransferase (Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ], SCOPe (2.08)
Dd1e2td_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases Arylamine N-acetyltransferase Arylamine N-acetyltransferase (Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ], SCOPe (2.08)
Ed1e2te_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases Arylamine N-acetyltransferase Arylamine N-acetyltransferase (Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ], SCOPe (2.08)
Fd1e2tf_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases Arylamine N-acetyltransferase Arylamine N-acetyltransferase (Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ], SCOPe (2.08)
Hd1e2th_ Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases Arylamine N-acetyltransferase Arylamine N-acetyltransferase (Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyArylamine N-acetyltransferase 8021689 4000879 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyCysteine proteinases 8034069 3001808 SCOP2 (2022-06-29)
GSCOP2B SuperfamilyCysteine proteinases 8034069 3001808 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCysteine proteinases 8034069 3001808 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyCysteine proteinases 8034069 3001808 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyCysteine proteinases 8034069 3001808 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyCysteine proteinases 8034069 3001808 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyCysteine proteinases 8034069 3001808 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyCysteine proteinases 8034069 3001808 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AAcetyltransf_2e1e2tA1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Acetyltransf_2ECOD (1.6)
GAcetyltransf_2e1e2tG1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Acetyltransf_2ECOD (1.6)
BAcetyltransf_2e1e2tB1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Acetyltransf_2ECOD (1.6)
CAcetyltransf_2e1e2tC1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Acetyltransf_2ECOD (1.6)
DAcetyltransf_2e1e2tD1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Acetyltransf_2ECOD (1.6)
EAcetyltransf_2e1e2tE1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Acetyltransf_2ECOD (1.6)
FAcetyltransf_2e1e2tF1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Acetyltransf_2ECOD (1.6)
HAcetyltransf_2e1e2tH1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Acetyltransf_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A6.10.140.1930 Special Helix non-globular Helix Hairpins CATH (4.3.0)
A3.30.1120.150 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain CATH (4.3.0)
A2.40.128.150 Mainly Beta Beta Barrel Lipocalin Cysteine proteinasesCATH (4.3.0)
G6.10.140.1930 Special Helix non-globular Helix Hairpins CATH (4.3.0)
G3.30.1120.150 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain CATH (4.3.0)
G2.40.128.150 Mainly Beta Beta Barrel Lipocalin Cysteine proteinasesCATH (4.3.0)
B6.10.140.1930 Special Helix non-globular Helix Hairpins CATH (4.3.0)
B3.30.1120.150 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain CATH (4.3.0)
B2.40.128.150 Mainly Beta Beta Barrel Lipocalin Cysteine proteinasesCATH (4.3.0)
C6.10.140.1930 Special Helix non-globular Helix Hairpins CATH (4.3.0)
C3.30.1120.150 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain CATH (4.3.0)
C2.40.128.150 Mainly Beta Beta Barrel Lipocalin Cysteine proteinasesCATH (4.3.0)
D6.10.140.1930 Special Helix non-globular Helix Hairpins CATH (4.3.0)
D3.30.1120.150 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain CATH (4.3.0)
D2.40.128.150 Mainly Beta Beta Barrel Lipocalin Cysteine proteinasesCATH (4.3.0)
E6.10.140.1930 Special Helix non-globular Helix Hairpins CATH (4.3.0)
E3.30.1120.150 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain CATH (4.3.0)
E2.40.128.150 Mainly Beta Beta Barrel Lipocalin Cysteine proteinasesCATH (4.3.0)
F6.10.140.1930 Special Helix non-globular Helix Hairpins CATH (4.3.0)
F3.30.1120.150 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain CATH (4.3.0)
F2.40.128.150 Mainly Beta Beta Barrel Lipocalin Cysteine proteinasesCATH (4.3.0)
H6.10.140.1930 Special Helix non-globular Helix Hairpins CATH (4.3.0)
H3.30.1120.150 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain CATH (4.3.0)
H2.40.128.150 Mainly Beta Beta Barrel Lipocalin Cysteine proteinasesCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF00797N-acetyltransferase (Acetyltransf_2)N-acetyltransferase- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE -

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR038765Papain-like cysteine peptidase superfamilyHomologous Superfamily
A, B, C, D, E
IPR001447Arylamine N-acetyltransferaseFamily

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
N-hydroxyarylamine O-acetyltransferase  M-CSA #515

The N acetyl-transferase (NAT) family of enzymes N-acetylate arlyhydrazines and arylamines. The transfer of an acetyl group from acetyl coenzyme A to a substrate was first noted in the deactivation of the drug isonizid, where the rate of deactivation varied between individuals, as explained by pharmacogenetic variation in the rate of NAT activity. NAT enzymes are also involved in the metabolism and detoxification of arylamine and arylhydroxylamine carcinogenic substrates.

Defined by 5 residues: GLU:A-42 [auth A-39]ARG:A-67 [auth A-64]CYS:A-72 [auth A-69]HIS:A-110 [auth A-107]ASP:A-125 [auth A-122]
 | 
 
Explore in 3D: M-CSA Motif Definition
Search M-CSA Motif
EC: 2.3.1.118 (PDB Primary Data)
EC: 2.3.1.5 (UniProt)