1QU0

CRYSTAL STRUCTURE OF THE FIFTH LAMININ G-LIKE MODULE OF THE MOUSE LAMININ ALPHA2 CHAIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d1qu0d_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Laminin G-like module	Laminin alpha2 chain	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1qu0a_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Laminin G-like module	Laminin alpha2 chain	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d1qu0b_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Laminin G-like module	Laminin alpha2 chain	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d1qu0c_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Laminin G-like module	Laminin alpha2 chain	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041419	3000120	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041419	3000120	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041419	3000120	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041419	3000120	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	Laminin_G_1	e1qu0D1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Laminin_G_1	ECOD (1.6)
A	Laminin_G_1	e1qu0A1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Laminin_G_1	ECOD (1.6)
B	Laminin_G_1	e1qu0B1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Laminin_G_1	ECOD (1.6)
C	Laminin_G_1	e1qu0C1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Laminin_G_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
A	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
B	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
C	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02210	Laminin G domain (Laminin_G_2)	Laminin G domain	This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	LAMININ ALPHA2 CHAIN	protein binding binding signaling receptor binding structural molecule activity extracellular matrix structural constituent	developmental process anatomical structure development tissue development anatomical structure morphogenesis animal organ development animal organ morphogenesis regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation positive regulation of biological process regulation of cell differentiation muscle cell differentiation developmental process anatomical structure development tissue development anatomical structure morphogenesis animal organ development animal organ morphogenesis regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation positive regulation of biological process regulation of cell differentiation muscle cell differentiation positive regulation of muscle cell differentiation muscle structure development positive regulation of developmental process regulation of muscle cell differentiation positive regulation of cell differentiation cell differentiation cellular process positive regulation of cellular process multicellular organismal process peripheral nervous system development nervous system development multicellular organism development neurogenesis gliogenesis glial cell differentiation Schwann cell differentiation system development regulation of cell motility regulation of locomotion regulation of cell migration cell migration cell motility locomotion cell adhesion positive regulation of cell adhesion regulation of cell adhesion cellular response to stimulus positive regulation of cell communication regulation of integrin-mediated signaling pathway positive regulation of signal transduction response to stimulus signaling regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of integrin-mediated signaling pathway signal transduction regulation of signaling integrin-mediated signaling pathway cell surface receptor signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling axonogenesis cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization cell projection morphogenesis neuron differentiation neuron projection morphogenesis cellular component organization or biogenesis plasma membrane bounded cell projection organization axon guidance axon development cell morphogenesis involved in neuron differentiation generation of neurons neuron projection guidance neuron development regulation of embryonic development regulation of multicellular organismal development embryo development regulation of multicellular organismal process regulation of cellular component organization extracellular matrix organization regulation of basement membrane organization regulation of extracellular matrix organization extracellular structure organization external encapsulating structure organization basement membrane organization modulation of chemical synaptic transmission synaptic signaling trans-synaptic signaling positive regulation of synaptic transmission, cholinergic cell-cell signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling synaptic transmission, cholinergic regulation of synaptic transmission, cholinergic	basement membrane cell periphery extracellular matrix cellular anatomical structure external encapsulating structure collagen-containing extracellular matrix sarcolemma plasma membrane membrane synaptic cleft extracellular region neuromuscular junction synapse cell junction basement membrane cell periphery extracellular matrix cellular anatomical structure external encapsulating structure collagen-containing extracellular matrix sarcolemma plasma membrane membrane synaptic cleft extracellular region neuromuscular junction synapse cell junction neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse dendrite dendritic tree protein-containing complex protein complex involved in cell-matrix adhesion protein complex involved in cell adhesion

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR008211	Laminin, N-terminal	Domain
A, B, C, D	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A, B, C, D	IPR002049	Laminin-type EGF domain	Domain
A, B, C, D	IPR010307	Laminin domain II	Domain
A, B, C, D	IPR000742	EGF-like domain	Domain
A, B, C, D	IPR001791	Laminin G domain	Domain
A, B, C, D	IPR009254	Laminin alpha, domain I	Domain
A, B, C, D	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A, B, C, D	IPR050440	Laminin/Netrin Extracellular Matrix	Family
A, B, C, D	IPR000034	Laminin IV	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.