Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyPOZ domain 8040250 3000894 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPOZ domain 8040250 3000894 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ABTBe1r2bA1 A: a+b two layersX: POZ domain (From Topology)H: POZ domain (From Topology)T: POZ domainF: BTBECOD (1.6)
BBTBe1r2bB1 A: a+b two layersX: POZ domain (From Topology)H: POZ domain (From Topology)T: POZ domainF: BTBECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.30.710.10 Alpha Beta 2-Layer Sandwich Potassium Channel Kv1.1 Chain ACATH (4.3.0)
B3.30.710.10 Alpha Beta 2-Layer Sandwich Potassium Channel Kv1.1 Chain ACATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF00651BTB/POZ domain (BTB)BTB/POZ domainThe BTB (for BR-C, ttk and bab) [1] or POZ (for Pox virus and Zinc finger) [2] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family o ...The BTB (for BR-C, ttk and bab) [1] or POZ (for Pox virus and Zinc finger) [2] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [2]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [3]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [4,5,6]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
C, D
Nuclear receptor co-repressor 2
A, B
B-cell lymphoma 6 protein

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
C, D
PharosQ9Y618
A, B
PharosP41182