2AP9

Crystal structure of acetylglutamate kinase from Mycobacterium tuberculosis CDC1551

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d2ap9c2	Alpha and beta proteins (a/b)	Carbamate kinase-like	Carbamate kinase-like	N-acetyl-l-glutamate kinase	N-acetyl-l-glutamate kinase	(Mycobacterium tuberculosis CDC1551 ) [TaxId: 83331 ],	SCOPe (2.08)
C	d2ap9c3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Mycobacterium tuberculosis CDC1551 ) [TaxId: 83331 ],	SCOPe (2.08)
D	d2ap9d2	Alpha and beta proteins (a/b)	Carbamate kinase-like	Carbamate kinase-like	N-acetyl-l-glutamate kinase	N-acetyl-l-glutamate kinase	(Mycobacterium tuberculosis CDC1551 ) [TaxId: 83331 ],	SCOPe (2.08)
D	d2ap9d3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Mycobacterium tuberculosis CDC1551 ) [TaxId: 83331 ],	SCOPe (2.08)
E	d2ap9e2	Alpha and beta proteins (a/b)	Carbamate kinase-like	Carbamate kinase-like	N-acetyl-l-glutamate kinase	N-acetyl-l-glutamate kinase	(Mycobacterium tuberculosis CDC1551 ) [TaxId: 83331 ],	SCOPe (2.08)
E	d2ap9e3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Mycobacterium tuberculosis CDC1551 ) [TaxId: 83331 ],	SCOPe (2.08)
F	d2ap9f2	Alpha and beta proteins (a/b)	Carbamate kinase-like	Carbamate kinase-like	N-acetyl-l-glutamate kinase	N-acetyl-l-glutamate kinase	(Mycobacterium tuberculosis CDC1551 ) [TaxId: 83331 ],	SCOPe (2.08)
F	d2ap9f3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Mycobacterium tuberculosis CDC1551 ) [TaxId: 83331 ],	SCOPe (2.08)
A	d2ap9a1	Alpha and beta proteins (a/b)	Carbamate kinase-like	Carbamate kinase-like	N-acetyl-l-glutamate kinase	N-acetyl-l-glutamate kinase	(Mycobacterium tuberculosis CDC1551 ) [TaxId: 83331 ],	SCOPe (2.08)
A	d2ap9a2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Mycobacterium tuberculosis CDC1551 ) [TaxId: 83331 ],	SCOPe (2.08)
B	d2ap9b2	Alpha and beta proteins (a/b)	Carbamate kinase-like	Carbamate kinase-like	N-acetyl-l-glutamate kinase	N-acetyl-l-glutamate kinase	(Mycobacterium tuberculosis CDC1551 ) [TaxId: 83331 ],	SCOPe (2.08)
B	d2ap9b3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Mycobacterium tuberculosis CDC1551 ) [TaxId: 83331 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Carbamate kinase-like	8037214	3001310	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Carbamate kinase-like	8037214	3001310	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Carbamate kinase-like	8037214	3001310	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Carbamate kinase-like	8037214	3001310	SCOP2B (2022-06-29)
A	SCOP2 Family	N-acetyl-l-glutamate kinase	8024835	4002449	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Carbamate kinase-like	8037214	3001310	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Carbamate kinase-like	8037214	3001310	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	AA_kinase	e2ap9C1	A: a/b three-layered sandwiches	X: Carbamate kinase-like (From Topology)	H: Carbamate kinase-like (From Topology)	T: Carbamate kinase-like	F: AA_kinase	ECOD (1.6)
D	AA_kinase	e2ap9D1	A: a/b three-layered sandwiches	X: Carbamate kinase-like (From Topology)	H: Carbamate kinase-like (From Topology)	T: Carbamate kinase-like	F: AA_kinase	ECOD (1.6)
E	AA_kinase	e2ap9E1	A: a/b three-layered sandwiches	X: Carbamate kinase-like (From Topology)	H: Carbamate kinase-like (From Topology)	T: Carbamate kinase-like	F: AA_kinase	ECOD (1.6)
F	AA_kinase	e2ap9F1	A: a/b three-layered sandwiches	X: Carbamate kinase-like (From Topology)	H: Carbamate kinase-like (From Topology)	T: Carbamate kinase-like	F: AA_kinase	ECOD (1.6)
A	AA_kinase	e2ap9A1	A: a/b three-layered sandwiches	X: Carbamate kinase-like (From Topology)	H: Carbamate kinase-like (From Topology)	T: Carbamate kinase-like	F: AA_kinase	ECOD (1.6)
B	AA_kinase	e2ap9B1	A: a/b three-layered sandwiches	X: Carbamate kinase-like (From Topology)	H: Carbamate kinase-like (From Topology)	T: Carbamate kinase-like	F: AA_kinase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.40.1160.10	Alpha Beta	3-Layer(aba) Sandwich	Carbamate kinase	Acetylglutamate kinase-like	CATH (4.3.0)
D	3.40.1160.10	Alpha Beta	3-Layer(aba) Sandwich	Carbamate kinase	Acetylglutamate kinase-like	CATH (4.3.0)
E	3.40.1160.10	Alpha Beta	3-Layer(aba) Sandwich	Carbamate kinase	Acetylglutamate kinase-like	CATH (4.3.0)
F	3.40.1160.10	Alpha Beta	3-Layer(aba) Sandwich	Carbamate kinase	Acetylglutamate kinase-like	CATH (4.3.0)
A	3.40.1160.10	Alpha Beta	3-Layer(aba) Sandwich	Carbamate kinase	Acetylglutamate kinase-like	CATH (4.3.0)
B	3.40.1160.10	Alpha Beta	3-Layer(aba) Sandwich	Carbamate kinase	Acetylglutamate kinase-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00696	Amino acid kinase family (AA_kinase)	Amino acid kinase family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	acetylglutamate kinase	kinase activity acetylglutamate kinase activity phosphotransferase activity, carboxyl group as acceptor transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding kinase activity acetylglutamate kinase activity phosphotransferase activity, carboxyl group as acceptor transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	L-arginine biosynthetic process oxoacid metabolic process glutamine family amino acid biosynthetic process amino acid metabolic process organic acid metabolic process organic acid biosynthetic process alpha-amino acid metabolic process carboxylic acid biosynthetic process glutamine family amino acid metabolic process arginine metabolic process small molecule metabolic process small molecule biosynthetic process carboxylic acid metabolic process primary metabolic process L-arginine biosynthetic process oxoacid metabolic process glutamine family amino acid biosynthetic process amino acid metabolic process organic acid metabolic process organic acid biosynthetic process alpha-amino acid metabolic process carboxylic acid biosynthetic process glutamine family amino acid metabolic process arginine metabolic process small molecule metabolic process small molecule biosynthetic process carboxylic acid metabolic process primary metabolic process L-amino acid biosynthetic process L-amino acid metabolic process proteinogenic amino acid metabolic process amino acid biosynthetic process biosynthetic process proteinogenic amino acid biosynthetic process metabolic process cellular process alpha-amino acid biosynthetic process ornithine metabolic process arginine biosynthetic process via ornithine non-proteinogenic amino acid metabolic process	cell periphery cellular anatomical structure plasma membrane membrane external encapsulating structure cell wall peptidoglycan-based cell wall intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR004662	Acetylglutamate kinase family	Family
A, B, C, D, E A, B, C, D, E, F	IPR001048	Aspartate/glutamate/uridylate kinase	Domain
A, B, C, D, E A, B, C, D, E, F	IPR037528	Acetylglutamate kinase ArgB	Family
A, B, C, D, E A, B, C, D, E, F	IPR001057	Glutamate/acetylglutamate kinase	Family
A, B, C, D, E A, B, C, D, E, F	IPR041727	N-Acetyl-L-glutamate kinase, cyclic	Family
A, B, C, D, E A, B, C, D, E, F	IPR036393	Acetylglutamate kinase-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.