2J67

The TIR domain of human Toll-Like Receptor 10 (TLR10)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2j67a_	Alpha and beta proteins (a/b)	Flavodoxin-like	Toll/Interleukin receptor TIR domain	Toll/Interleukin receptor TIR domain	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2j67b_	Alpha and beta proteins (a/b)	Flavodoxin-like	Toll/Interleukin receptor TIR domain	Toll/Interleukin receptor TIR domain	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Toll/Interleukin receptor TIR domain	8066250	3001184	SCOP2B (2022-06-29)
B	SCOP2 Family	Toll/Interleukin receptor TIR domain	8066249	4003648	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Toll/Interleukin receptor TIR domain	8066250	3001184	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TIR	e2j67A1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Toll/Interleukin receptor TIR domain (From Topology)	T: Toll/Interleukin receptor TIR domain	F: TIR	ECOD (1.6)
B	TIR	e2j67B1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Toll/Interleukin receptor TIR domain (From Topology)	T: Toll/Interleukin receptor TIR domain	F: TIR	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.10140	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Toll/interleukin-1 receptor homology (TIR) domain	CATH (4.3.0)
B	3.40.50.10140	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Toll/interleukin-1 receptor homology (TIR) domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01582	TIR domain (TIR)	TIR domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	TOLL LIKE RECEPTOR 10	molecular transducer activity signaling receptor activity hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity amide binding binding lipid binding lipopeptide binding protein binding Toll-like receptor 2 binding signaling receptor binding molecular transducer activity signaling receptor activity hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity amide binding binding lipid binding lipopeptide binding protein binding Toll-like receptor 2 binding signaling receptor binding Toll-like receptor binding identical protein binding transmembrane signaling receptor activity	response to stimulus immune response immune system process defense response response to stress inflammatory response biological process involved in interspecies interaction between organisms response to other organism defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism innate immune response response to external biotic stimulus response to stimulus immune response immune system process defense response response to stress inflammatory response biological process involved in interspecies interaction between organisms response to other organism defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism innate immune response response to external biotic stimulus cellular response to stimulus cellular response to bacterial lipoprotein cellular response to molecule of bacterial origin response to bacterial lipoprotein response to bacterial lipopeptide cellular response to biotic stimulus cellular response to bacterial lipopeptide response to bacterium cellular process response to molecule of bacterial origin regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus regulation of cellular process pattern recognition receptor signaling pathway regulation of response to external stimulus toll-like receptor signaling pathway signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response regulation of response to stress regulation of immune system process signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process positive regulation of innate immune response regulation of innate immune response biological regulation regulation of response to stimulus positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response	protein-containing complex receptor complex cellular anatomical structure membrane cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain	Domain
A, B	IPR001611	Leucine-rich repeat	Repeat
A, B	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A, B	IPR017241	Toll-like receptor	Family
A, B	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A, B	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily	Homologous Superfamily
A, B	IPR000483	Cysteine-rich flanking region, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9BXR5	allergic rhinitis malignant glioma pilocytic astrocytoma Familial Ménière disease medulloblastoma psoriasis interstitial cystitis osteosarcoma ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.