4NWU
Crystal structure of APE1551, an anti-human NGF Fab with a nine amino acid insertion in CDR H1
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- IMGT Antibody Annotation
- SAbDab Antibody Annotation
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B [auth L] | d4nwul2 | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | C1 set domains (antibody constant domain-like) | automated matches | human (Homo sapiens ) [TaxId: 9606 ], human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B [auth L] | d4nwul1 | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | automated matches | automated matches | human (Homo sapiens ) [TaxId: 9606 ], human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A [auth H] | SCOP2B Superfamily | Immunoglobulin (Ig) domain-like | 8091519 | 3000071 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth H] | C1-set_1 | e4nwuH2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
A [auth H] | V-set_10 | e4nwuH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_10 | ECOD (1.6) |
B [auth L] | C1-set_4 | e4nwuL2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_4 | ECOD (1.6) |
B [auth L] | V-set | e4nwuL1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A [auth H] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
B [auth L] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
A [auth H] | APE1551 Ab | VH-CH1 | Homo sapiens (human) | IGHV1-69*01, IGHV1-69*12, IGHV1-69*13, IGHV1-69D*01, IGHJ4*01, IGHJ4*02, IGHJ4*03, IGHG1*01, IGHG1*02, IGHG1*04 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_KAPPA | IMGT (202447-0) |
B [auth L] | APE1551 Ab | L-KAPPA | Homo sapiens (human) | IGKV4-1*01, IGKJ5*01, IGKC*01 | V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA | IG | FAB-GAMMA-1_KAPPA | IMGT (202447-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
A [auth H] | Heavy Chain | IGHV1 | - | - | SAbDab (2024-11-29) |
B [auth L] | Light Chain | IGKV4 | Kappa | - | SAbDab (2024-11-29) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth H] | PF07654 | Immunoglobulin C1-set domain (C1-set) | Immunoglobulin C1-set domain | - | Domain |
B [auth L] | PF07686 | Immunoglobulin V-set domain (V-set) | Immunoglobulin V-set domain | This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others. | Domain |
B [auth L] | PF07654 | Immunoglobulin C1-set domain (C1-set) | Immunoglobulin C1-set domain | - | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A [auth H] | IPR036179 | Immunoglobulin-like domain superfamily | Homologous Superfamily |
A [auth H] | IPR050380 | Immune Recognition and Response Modulators | Family |
A [auth H] | IPR003597 | Immunoglobulin C1-set | Domain |
A [auth H] | IPR013783 | Immunoglobulin-like fold | Homologous Superfamily |
A [auth H] | IPR007110 | Immunoglobulin-like domain | Domain |
A [auth H] | IPR003006 | Immunoglobulin/major histocompatibility complex, conserved site | Conserved Site |
B [auth L] | IPR003597 | Immunoglobulin C1-set | Domain |
B [auth L] | IPR050150 | Immunoglobulin Variable Light Chain | Family |
B [auth L] | IPR013783 | Immunoglobulin-like fold | Homologous Superfamily |
B [auth L] | IPR036179 | Immunoglobulin-like domain superfamily | Homologous Superfamily |
B [auth L] | IPR013106 | Immunoglobulin V-set domain | Domain |
B [auth L] | IPR003599 | Immunoglobulin domain subtype | Domain |
B [auth L] | IPR007110 | Immunoglobulin-like domain | Domain |
B [auth L] | IPR003006 | Immunoglobulin/major histocompatibility complex, conserved site | Conserved Site |