Annotations: 5H5S

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GSHPx	e5h5sA1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: GSHPx	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00255	Glutathione peroxidase (GSHPx)	Glutathione peroxidase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	phospholipid-hydroperoxide glutathione peroxidase activity peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity glutathione peroxidase activity identical protein binding protein binding binding selenium binding small molecule binding	cellular component organization cellular component biogenesis protein polymerization cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction cellular component organization cellular component biogenesis protein polymerization cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation icosanoid metabolic process fatty acid metabolic process oxoacid metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process small molecule metabolic process metabolic process lipoxygenase pathway monocarboxylic acid metabolic process lipid metabolic process phospholipid metabolic process organophosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process apoptotic process cell death programmed cell death multicellular organismal process head development animal organ development brain development nervous system development multicellular organism development cerebellum development central nervous system development metencephalon development anatomical structure development hindbrain development system development negative regulation of ferroptosis regulation of biological process regulation of cellular process negative regulation of programmed cell death biological regulation negative regulation of biological process regulation of programmed cell death negative regulation of cellular process regulation of ferroptosis ferroptosis plasma membrane bounded cell projection organization cellular developmental process cell projection organization cell development neuron projection development generation of neurons neurogenesis neuron differentiation dendrite development cell differentiation neuron development long-chain fatty acid metabolic process unsaturated fatty acid metabolic process arachidonate metabolic process olefinic compound metabolic process response to oxidative stress response to stimulus response to stress monocarboxylic acid biosynthetic process small molecule biosynthetic process long-chain fatty acid biosynthetic process lipid biosynthetic process organic acid biosynthetic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process multicellular organism growth developmental growth growth biological process involved in interspecies interaction between organisms response to lipid response to other organism response to oxygen-containing compound response to external stimulus response to lipopolysaccharide response to biotic stimulus response to bacterium response to chemical response to external biotic stimulus response to molecule of bacterial origin response to estradiol response to organic cyclic compound chromatin organization	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle organelle envelope nuclear envelope nucleus endomembrane system extracellular exosome extracellular vesicle membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle organelle envelope nuclear envelope nucleus endomembrane system extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol protein-containing complex
B	GXpep-3	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR029760	Glutathione peroxidase conserved site	Conserved Site
A	IPR029759	Glutathione peroxidase active site	Active Site
A	IPR000889	Glutathione peroxidase	Family
A	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P36969	spondylometaphyseal dysplasia, Sedaghatian type colorectal cancer Fibrosis cadmium poisoning glucose intolerance cryptorchidism male infertility breast carcinoma congestive heart failure heart failure pancreatic ductal adenocarcinoma colorectal carcinoma Crohn disease age-related macular degeneration breast cancer spondylometaphyseal dysplasia, Sedaghatian type colorectal cancer Fibrosis cadmium poisoning glucose intolerance cryptorchidism male infertility breast carcinoma congestive heart failure heart failure pancreatic ductal adenocarcinoma colorectal carcinoma Crohn disease age-related macular degeneration breast cancer plasma cell myeloma wet macular degeneration fatty liver disease inflammatory bowel disease ovarian cancer skin basal cell carcinoma ductal breast carcinoma in situ

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	CSD	Parent Component: CYS RESID: AA0262 PSI-MOD : L-cysteine sulfinic acid MOD:00267

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.