6AH4
Structure of human P2X3 receptor in complex with ATP and Ca2+ ion
External Resource: Annotation
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
- Membrane Protein Annotation: OPM
- Membrane Protein Annotation: PDBTM
- Membrane Protein Annotation: MemProtMD
- Membrane Protein Annotation: mpstruc
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
B | SCOP2B Superfamily | P2X receptor-like | 8053195 | 3002165 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | P2X receptor-like | 8053195 | 3002165 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | P2X receptor-like | 8053195 | 3002165 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | P2X_receptor | e6ah4B1 | A: beta sandwiches | X: P2X purinoceptor (From Topology) | H: P2X purinoceptor (From Topology) | T: P2X purinoceptor | F: P2X_receptor | ECOD (1.6) |
A | P2X_receptor | e6ah4A1 | A: beta sandwiches | X: P2X purinoceptor (From Topology) | H: P2X purinoceptor (From Topology) | T: P2X purinoceptor | F: P2X_receptor | ECOD (1.6) |
C | P2X_receptor | e6ah4C1 | A: beta sandwiches | X: P2X purinoceptor (From Topology) | H: P2X purinoceptor (From Topology) | T: P2X purinoceptor | F: P2X_receptor | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 2.60.490.10 | Mainly Beta | Sandwich | atp-gated p2x4 ion channel fold | atp-gated p2x4 ion channel domain | CATH (utative) |
A | 2.60.490.10 | Mainly Beta | Sandwich | atp-gated p2x4 ion channel fold | atp-gated p2x4 ion channel domain | CATH (utative) |
C | 2.60.490.10 | Mainly Beta | Sandwich | atp-gated p2x4 ion channel fold | atp-gated p2x4 ion channel domain | CATH (utative) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00864 | ATP P2X receptor (P2X_receptor) | ATP P2X receptor | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR053792 | ATP P2X receptor, conserved site | Conserved Site | |
IPR003046 | P2X3 purinoceptor | Family | |
IPR001429 | P2X purinoreceptor | Family | |
IPR027309 | P2X purinoreceptor extracellular domain superfamily | Homologous Superfamily |
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target   | Associated Disease |
---|---|---|
P56373 | : 
Membrane Protein Annotation: OPM OPM Database Homepage
Chains | External Link | Type | Class | Superfamily | Family |
---|---|---|---|---|---|
OPM | Transmembrane | Alpha-helical polytopic | ENaC/P2X | ATP-gated cation channel |
Membrane Protein Annotation: PDBTM PDBTM Database Homepage
Chains | External Link | Comment |
---|---|---|
PDBTM | Annotated as membrane protein by PDBTM |
Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage
Chains | External Link | Comment |
---|---|---|
MemProtMD | Annotated as membrane protein by MemProtMD |
Membrane Protein Annotation: mpstruc mpstruc Database Homepage
Chains | Resource Link | Group | Subgroup | Protein |
---|---|---|---|---|
mpstruc | TRANSMEMBRANE PROTEINS: ALPHA-HELICAL | Channels: Other Ion Channels | ATP-gated P2X3 ion channel in complex with ATP and Ca2+ |