6EIE

Ras guanine nucleotide exchange factor SOS2 (Rem-cdc25), with surface mutations

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6eiea1	All alpha proteins	Ras GEF	Ras GEF	Ras GEF	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d6eiea2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RasGEF	e6eieA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ras GEF (From Topology)	T: Ras GEF	F: RasGEF	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.870.10	Mainly Alpha	Up-down Bundle	Son of sevenless (SoS) protein	Chain S, domain 1	CATH (4.3.0)
A	1.10.840.10	Mainly Alpha	Orthogonal Bundle	Son of Sevenless (SoS) protein	Chain S, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00617	RasGEF domain (RasGEF)	RasGEF domain	-	Family
A	PF00618	RasGEF N-terminal motif (RasGEF_N)	RasGEF N-terminal motif	A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Son of sevenless homolog 2	GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity protein heterodimerization activity protein binding binding protein dimerization activity	multicellular organismal process regulation of cellular process regulation of leukocyte activation regulation of cell activation lymphocyte activation leukocyte proliferation leukocyte activation T cell activation lymphocyte proliferation regulation of multicellular organismal process regulation of immune system process T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation multicellular organismal process regulation of cellular process regulation of leukocyte activation regulation of cell activation lymphocyte activation leukocyte proliferation leukocyte activation T cell activation lymphocyte proliferation regulation of multicellular organismal process regulation of immune system process T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation regulation of biological process cell population proliferation biological regulation cell activation regulation of T cell activation regulation of T cell proliferation regulation of cell population proliferation mononuclear cell proliferation immune system process regulation of mononuclear cell proliferation cellular process regulation of lymphocyte activation cellular response to nitrogen compound cellular response to stimulus response to stimulus signaling response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular response to endogenous stimulus response to hormone signal transduction enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus cell surface receptor signaling pathway response to endogenous stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical response to insulin cellular response to insulin stimulus regulation of leukocyte differentiation cellular developmental process regulation of developmental process cell development regulation of T cell differentiation in thymus mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation regulation of cell development regulation of T cell differentiation T cell differentiation in thymus multicellular organism development cell differentiation anatomical structure development T cell differentiation developmental process regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis regulation of hemopoiesis leukocyte differentiation regulation of pro-B cell differentiation regulation of lymphoid progenitor cell differentiation pro-B cell differentiation lymphoid progenitor cell differentiation regulation of hematopoietic progenitor cell differentiation hematopoietic progenitor cell differentiation positive regulation of cell communication small GTPase-mediated signal transduction positive regulation of signal transduction regulation of small GTPase mediated signal transduction positive regulation of biological process regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette positive regulation of cellular process regulation of signaling positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of small GTPase mediated signal transduction positive regulation of signaling B cell homeostasis multicellular organismal-level homeostasis leukocyte homeostasis homeostatic process homeostasis of number of cells lymphocyte homeostasis Ras protein signal transduction	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR009072	Histone-fold	Homologous Superfamily
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR000219	Dbl homology (DH) domain	Domain
A	IPR008937	Ras-like guanine nucleotide exchange factor	Family
A	IPR019804	Ras guanine-nucleotide exchange factor, conserved site	Conserved Site
A	IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal	Domain
A	IPR036964	Ras guanine-nucleotide exchange factor, catalytic domain superfamily	Homologous Superfamily
A	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR023578	Ras guanine nucleotide exchange factor domain superfamily	Homologous Superfamily
A	IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	Domain
A	IPR055251	SOS1/NGEF-like, PH domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q07890	Noonan syndrome Noonan syndrome 9 atypical teratoid rhabdoid tumor Gaucher disease hydrops fetalis medulloblastoma osteosarcoma psoriasis cutaneous lupus erythematosus glioblastoma hypertensive disorder ovarian cancer rheumatoid arthritis dermatomyositis hereditary spastic paraplegia Noonan syndrome Noonan syndrome 9 atypical teratoid rhabdoid tumor Gaucher disease hydrops fetalis medulloblastoma osteosarcoma psoriasis cutaneous lupus erythematosus glioblastoma hypertensive disorder ovarian cancer rheumatoid arthritis dermatomyositis hereditary spastic paraplegia malignant ependymoma plasma cell myeloma ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.