6QJ4

Crystal structure of the C. thermophilum condensin Ycs4-Brn1 subcomplex bound to the Smc4 ATPase head in complex with the C-terminal domain of Brn1

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HEAT_2	e6qj4A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: HEAT_2	ECOD (1.6)
C	SMC_N	e6qj4C1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: SMC_N	ECOD (1.6)
E	UNK_F_TYPE	e6qj4E1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: UNK_F_TYPE	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF12717	non-SMC mitotic condensation complex subunit 1 (Cnd1)	non-SMC mitotic condensation complex subunit 1	-	Repeat
A	PF12922	non-SMC mitotic condensation complex subunit 1, N-term (Cnd1_N)	non-SMC mitotic condensation complex subunit 1, N-term	-	Repeat
C	PF02463	RecF/RecN/SMC N terminal domain (SMC_N)	RecF/RecN/SMC N terminal domain	This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. T ...	This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics [1]. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
D	Brn1	-	-	-
A	Condensin complex subunit 1,Condensin complex subunit 1,Condensin complex subunit 1	protein binding binding histone binding	mitotic nuclear division mitotic chromosome condensation organelle fission chromosome organization sister chromatid segregation mitotic cell cycle cellular component organization organelle organization nuclear division mitotic cell cycle process chromosome condensation mitotic sister chromatid segregation nuclear chromosome segregation cellular process mitotic nuclear division mitotic chromosome condensation organelle fission chromosome organization sister chromatid segregation mitotic cell cycle cellular component organization organelle organization nuclear division mitotic cell cycle process chromosome condensation mitotic sister chromatid segregation nuclear chromosome segregation cellular process cell cycle cellular component organization or biogenesis chromosome segregation cell cycle process meiotic chromosome condensation sexual reproduction reproductive process meiotic cell cycle meiotic cell cycle process chromosome organization involved in meiotic cell cycle cell division	intracellular anatomical structure intracellular membraneless organelle chromosome chromosomal region intracellular organelle cellular anatomical structure organelle membraneless organelle chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B	Condensin complex subunit 2	chromatin binding binding	mitotic nuclear division mitotic chromosome condensation organelle fission chromosome organization sister chromatid segregation mitotic cell cycle cellular component organization organelle organization nuclear division mitotic cell cycle process chromosome condensation mitotic sister chromatid segregation nuclear chromosome segregation cellular process mitotic nuclear division mitotic chromosome condensation organelle fission chromosome organization sister chromatid segregation mitotic cell cycle cellular component organization organelle organization nuclear division mitotic cell cycle process chromosome condensation mitotic sister chromatid segregation nuclear chromosome segregation cellular process cell cycle cellular component organization or biogenesis chromosome segregation cell cycle process cell division	cellular anatomical structure intracellular anatomical structure cytoplasm intracellular organelle protein-containing complex organelle membraneless organelle intracellular membraneless organelle chromosome condensin complex
C	Uncharacterized protein,Uncharacterized protein	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding	mitotic nuclear division mitotic chromosome condensation organelle fission chromosome organization sister chromatid segregation mitotic cell cycle cellular component organization organelle organization nuclear division mitotic cell cycle process chromosome condensation mitotic sister chromatid segregation nuclear chromosome segregation cellular process mitotic nuclear division mitotic chromosome condensation organelle fission chromosome organization sister chromatid segregation mitotic cell cycle cellular component organization organelle organization nuclear division mitotic cell cycle process chromosome condensation mitotic sister chromatid segregation nuclear chromosome segregation cellular process cell cycle cellular component organization or biogenesis chromosome segregation cell cycle process regulation of cellular process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process	intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromosome membrane-bounded organelle nucleus intracellular membrane-bounded organelle
E	Condensin complex subunit 2	chromatin binding binding	mitotic nuclear division mitotic chromosome condensation organelle fission chromosome organization sister chromatid segregation mitotic cell cycle cellular component organization organelle organization nuclear division mitotic cell cycle process chromosome condensation mitotic sister chromatid segregation nuclear chromosome segregation cellular process mitotic nuclear division mitotic chromosome condensation organelle fission chromosome organization sister chromatid segregation mitotic cell cycle cellular component organization organelle organization nuclear division mitotic cell cycle process chromosome condensation mitotic sister chromatid segregation nuclear chromosome segregation cellular process cell cycle cellular component organization or biogenesis chromosome segregation cell cycle process cell division	cellular anatomical structure intracellular anatomical structure cytoplasm intracellular organelle protein-containing complex organelle membraneless organelle intracellular membraneless organelle chromosome condensin complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR007673	Condensin subunit 1	Family
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR026971	Condensin subunit 1/Condensin-2 complex subunit D3	Family
A	IPR032682	Condensin complex subunit 1, C-terminal	Domain
A	IPR024324	Condensin complex subunit 1, N-terminal	Domain
B	IPR022816	Condensin complex subunit 2/barren	Family
C	IPR017956	AT hook, DNA-binding motif	Conserved Site
C	IPR000637	HMG-I/HMG-Y, DNA-binding, conserved site	Conserved Site
C	IPR010935	SMCs flexible hinge	Domain
C	IPR036277	SMCs flexible hinge superfamily	Homologous Superfamily
C	IPR003395	RecF/RecN/SMC, N-terminal	Domain
C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
E	IPR022816	Condensin complex subunit 2/barren	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.