6RJC
E.coli transketolase apoenzyme
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Thiamin diphosphate-binding fold (THDP-binding) | 8036682 | 3001790 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Thiamin diphosphate-binding fold (THDP-binding) | 8036680 | 3001790 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | TK C-terminal domain-like | 8036683 | 3000424 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Thiamin diphosphate-binding fold (THDP-binding) | 8036682 | 3001790 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | TK C-terminal domain-like | 8036683 | 3000424 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Thiamin diphosphate-binding fold (THDP-binding) | 8036680 | 3001790 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Transketolase_C_1 | e6rjcA3 | A: a/b three-layered sandwiches | X: TK C-terminal domain-like (From Topology) | H: TK C-terminal domain-like (From Topology) | T: TK C-terminal domain-like | F: Transketolase_C_1 | ECOD (1.6) |
A | Transketolase_N | e6rjcA2 | A: a/b three-layered sandwiches | X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | T: Thiamin diphosphate-binding fold (THDP-binding) | F: Transketolase_N | ECOD (1.6) |
A | Transket_pyr | e6rjcA1 | A: a/b three-layered sandwiches | X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | T: Thiamin diphosphate-binding fold (THDP-binding) | F: Transket_pyr | ECOD (1.6) |
B | Transketolase_C_1 | e6rjcB2 | A: a/b three-layered sandwiches | X: TK C-terminal domain-like (From Topology) | H: TK C-terminal domain-like (From Topology) | T: TK C-terminal domain-like | F: Transketolase_C_1 | ECOD (1.6) |
B | Transketolase_N | e6rjcB1 | A: a/b three-layered sandwiches | X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | T: Thiamin diphosphate-binding fold (THDP-binding) | F: Transketolase_N | ECOD (1.6) |
B | Transket_pyr | e6rjcB3 | A: a/b three-layered sandwiches | X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology) | T: Thiamin diphosphate-binding fold (THDP-binding) | F: Transket_pyr | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.40.50.970 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains | CATH (utative) |
A | 3.40.50.920 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | CATH (utative) | |
B | 3.40.50.970 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains | CATH (utative) |
B | 3.40.50.920 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | CATH (utative) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02779 | Transketolase, pyrimidine binding domain (Transket_pyr) | Transketolase, pyrimidine binding domain | This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases. | Domain | |
PF02780 | Transketolase, C-terminal domain (Transketolase_C) | Transketolase, C-terminal domain | The C-terminal domain of transketolase has been proposed as a regulatory molecule binding site [2]. | Domain | |
PF00456 | Transketolase, thiamine diphosphate binding domain (Transketolase_N) | Transketolase, thiamine diphosphate binding domain | This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit Swiss:P37941 EC:1.2.4.4. Both these enzymes utilise thiamine pyrophosphate as a cofactor, suggesting there may be common ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR033247 | Transketolase family | Family | |
IPR005474 | Transketolase, N-terminal | Domain | |
IPR029061 | Thiamin diphosphate-binding fold | Homologous Superfamily | |
IPR009014 | Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II | Homologous Superfamily | |
IPR049557 | Transketolase conserved site | Conserved Site | |
IPR005478 | Transketolase, bacterial-like | Family | |
IPR005475 | Transketolase-like, pyrimidine-binding domain | Domain | |
IPR055152 | Transketolase-like, C-terminal domain | Domain | |
IPR020826 | Transketolase binding site | Binding Site |