Annotations: 6WPA

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TetR_N	e6wpaA1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: TetR_N	ECOD (1.6)
A	TetR_C_11_like_1	e6wpaA2	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: TetR_C_11_like_1	ECOD (1.6)
B	TetR_N	e6wpaB1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: TetR_N	ECOD (1.6)
B	TetR_C_11_like_1	e6wpaB2	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: TetR_C_11_like_1	ECOD (1.6)
E [auth C]	TetR_N	e6wpaC1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: TetR_N	ECOD (1.6)
E [auth C]	TetR_C_11_like_1	e6wpaC2	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: TetR_C_11_like_1	ECOD (1.6)
F [auth D]	TetR_N	e6wpaD2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: TetR_N	ECOD (1.6)
F [auth D]	TetR_C_11_like_1	e6wpaD1	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: TetR_C_11_like_1	ECOD (1.6)
G [auth E]	TetR_N	e6wpaE1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: TetR_N	ECOD (1.6)
G [auth E]	TetR_C_11_like_1	e6wpaE2	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: TetR_C_11_like_1	ECOD (1.6)
H [auth F]	TetR_N	e6wpaF2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: TetR_N	ECOD (1.6)
H [auth F]	TetR_C_11_like_1	e6wpaF1	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: TetR_C_11_like_1	ECOD (1.6)
I [auth G]	TetR_N	e6wpaG1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: TetR_N	ECOD (1.6)
I [auth G]	TetR_C_11_like_1	e6wpaG2	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: TetR_C_11_like_1	ECOD (1.6)
J [auth H]	TetR_N	e6wpaH2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: TetR_N	ECOD (1.6)
J [auth H]	TetR_C_11_like_1	e6wpaH1	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: TetR_C_11_like_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, E [auth C], F [auth D], G [auth E], A, B, E [auth C], F [auth D], G [auth E], H [auth F], I [auth G], J [auth H]	PF00440	Bacterial regulatory proteins, tetR family (TetR_N)	Bacterial regulatory proteins, tetR family	-	Domain
A, B, E [auth C], F [auth D], G [auth E], A, B, E [auth C], F [auth D], G [auth E], H [auth F], I [auth G], J [auth H]	PF21935	Tetracyclin repressor-like, C-terminal domain (TetR_C_45)	Tetracyclin repressor-like, C-terminal domain	This domain is found at the C-terminal end of CprB from Streptomyces coelicolor (Swiss:O66122) and similar bacterial transcriptional regulators. This region is the ligand-binding domain (LBD) [1,2]. It is often found associated with Pfam:PF00440.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, E [auth C], F [auth D], G [auth E], A, B, E [auth C], F [auth D], G [auth E], H [auth F], I [auth G], J [auth H]	AvaR1	DNA binding binding organic cyclic compound binding nucleic acid binding	regulation of cellular process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process biological regulation primary metabolic process regulation of cellular process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process	-
C [auth M], D [auth N]	PAL2-1-5'-GC	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, E [auth C], F [auth D], G [auth E], A, B, E [auth C], F [auth D], G [auth E], H [auth F], I [auth G], J [auth H]	IPR023772	DNA-binding HTH domain, TetR-type, conserved site	Conserved Site
A, B, E [auth C], F [auth D], G [auth E], A, B, E [auth C], F [auth D], G [auth E], H [auth F], I [auth G], J [auth H]	IPR009057	Homedomain-like superfamily	Homologous Superfamily
A, B, E [auth C], F [auth D], G [auth E], A, B, E [auth C], F [auth D], G [auth E], H [auth F], I [auth G], J [auth H]	IPR047923	A-factor receptor protein-like	Family
A, B, E [auth C], F [auth D], G [auth E], A, B, E [auth C], F [auth D], G [auth E], H [auth F], I [auth G], J [auth H]	IPR054126	CprB tetracyclin repressor-like, C-terminal domain	Domain
A, B, E [auth C], F [auth D], G [auth E], A, B, E [auth C], F [auth D], G [auth E], H [auth F], I [auth G], J [auth H]	IPR001647	DNA-binding HTH domain, TetR-type	Domain
A, B, E [auth C], F [auth D], G [auth E], A, B, E [auth C], F [auth D], G [auth E], H [auth F], I [auth G], J [auth H]	IPR036271	Tetracyclin repressor-like, C-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.