7OKS

X-ray structure of soluble EPCR in P212121 space group

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	MHC antigen-recognition domain	8041433	3000521	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	MHC antigen-recognition domain	8041433	3000521	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	MHC antigen-recognition domain	8041433	3000521	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	MHC antigen-recognition domain	8041433	3000521	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MHC_I	e7oksA1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
C	MHC_I	e7oksC1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
D	MHC_I	e7oksD1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
B	MHC_I	e7oksB1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Endothelial protein C receptor	molecular transducer activity signaling receptor activity	multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding regulation of biological process negative regulation of coagulation negative regulation of biological process multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding regulation of biological process negative regulation of coagulation negative regulation of biological process regulation of multicellular organismal process negative regulation of multicellular organismal process regulation of coagulation	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton cell surface perinuclear region of cytoplasm cytoplasm cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR037055	MHC class I-like antigen recognition-like superfamily	Homologous Superfamily
A, B, C, D	IPR015669	Endothelial protein C receptor	Family
A, B, C, D	IPR011161	MHC class I-like antigen recognition-like	Domain
A, B, C, D	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q9UNN8	coronary artery disease ulcerative colitis Liver Cirrhosis, Experimental astrocytic tumor gastric carcinoma invasive ductal breast carcinoma melanoma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor cystic fibrosis heart disease oligodendroglioma skin basal cell carcinoma vascular disease ductal breast carcinoma in situ coronary artery disease ulcerative colitis Liver Cirrhosis, Experimental astrocytic tumor gastric carcinoma invasive ductal breast carcinoma melanoma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor cystic fibrosis heart disease oligodendroglioma skin basal cell carcinoma vascular disease ductal breast carcinoma in situ malignant mesothelioma ovarian cancer thrombotic disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.