7SZC

Crystal Structure Analysis of human PRPK complex with a compound

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	RIO1	e7szcC1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: RIO1	ECOD (1.6)
A	RIO1	e7szcA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: RIO1	ECOD (1.6)
B	CGI-121	e7szcB1	A: a+b two layers	X: Alpha-beta plaits	H: PF0523-like (From Topology)	T: PF0523-like	F: CGI-121	ECOD (1.6)
D	CGI-121	e7szcD1	A: a+b two layers	X: Alpha-beta plaits	H: PF0523-like (From Topology)	T: PF0523-like	F: CGI-121	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF06293	Lipopolysaccharide kinase (Kdo/WaaP) family (Kdo)	Lipopolysaccharide kinase (Kdo/WaaP) family	-	Family
B, D	PF08617	Kinase binding protein CGI-121 (CGI-121)	Kinase binding protein CGI-121	CGI-121 has been shown to bind to the p53-related protein kinase (PRPK) [1]. PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The K ...	CGI-121 has been shown to bind to the p53-related protein kinase (PRPK) [1]. PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation [2]. Interestingly this family also include archaeal homologues, formerly in the DUF509 family. A structure for these proteins has been solved by structural genomics.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	EKC/KEOPS complex subunit TP53RK	p53 binding protein binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding p53 binding protein binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups hydrolase activity protein serine kinase activity	protein phosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process cellular response to stimulus regulation of biological process regulation of signaling protein phosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process response to stimulus signaling biological regulation regulation of signal transduction signal transduction by p53 class mediator intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus regulation of signal transduction by p53 class mediator regulation of cell communication signal transduction RNA metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process biosynthetic process tRNA processing RNA processing tRNA threonylcarbamoyladenosine metabolic process	protein-containing complex catalytic complex transferase complex EKC/KEOPS complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle protein-containing complex catalytic complex transferase complex EKC/KEOPS complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
B, D	EKC/KEOPS complex subunit TPRKB	protein binding binding kinase binding enzyme binding protein kinase binding	tRNA threonylcarbamoyladenosine modification tRNA modification RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA modification biosynthetic process tRNA processing tRNA threonylcarbamoyladenosine modification tRNA modification RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA modification biosynthetic process tRNA processing macromolecule modification tRNA threonylcarbamoyladenosine metabolic process metabolic process cellular process macromolecule metabolic process RNA processing	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex catalytic complex transferase complex EKC/KEOPS complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR022495	Serine/threonine-protein kinase Bud32	Family
A, C	IPR008266	Tyrosine-protein kinase, active site	Active Site
A, C	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, C	IPR000719	Protein kinase domain	Domain
B, D	IPR036504	CGI121/TPRKB superfamily	Homologous Superfamily
B, D	IPR013926	CGI121/TPRKB	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: Q96S44	Galloway-Mowat syndrome 4 Galloway-Mowat syndrome atypical teratoid rhabdoid tumor ductal breast carcinoma in situ Galloway-Mowat syndrome 1 invasive ductal breast carcinoma medulloblastoma ovarian cancer breast carcinoma epilepsy large cell medulloblastoma microcephaly chronic kidney disease glioblastoma malignant glioma Galloway-Mowat syndrome 4 Galloway-Mowat syndrome atypical teratoid rhabdoid tumor ductal breast carcinoma in situ Galloway-Mowat syndrome 1 invasive ductal breast carcinoma medulloblastoma ovarian cancer breast carcinoma epilepsy large cell medulloblastoma microcephaly chronic kidney disease glioblastoma malignant glioma osteosarcoma
B, D	Pharos: Q9Y3C4	Galloway-Mowat syndrome Galloway-Mowat syndrome 5 astrocytic tumor glioblastoma limb-girdle muscular dystrophy medulloblastoma ovarian cancer breast carcinoma Galloway-Mowat syndrome 1 hereditary spastic paraplegia lung cancer microcephaly plasma cell myeloma epilepsy large cell medulloblastoma Galloway-Mowat syndrome Galloway-Mowat syndrome 5 astrocytic tumor glioblastoma limb-girdle muscular dystrophy medulloblastoma ovarian cancer breast carcinoma Galloway-Mowat syndrome 1 hereditary spastic paraplegia lung cancer microcephaly plasma cell myeloma epilepsy large cell medulloblastoma lymphoplasmacytic lymphoma oligodendroglioma primitive neuroectodermal tumor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.