Annotations: 8KA5

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03372	Endonuclease/Exonuclease/phosphatase family (Exo_endo_phos)	Endonuclease/Exonuclease/phosphatase family	This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g Swiss:P27695, DNase I proteins EC:3. ...	This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g Swiss:P27695, DNase I proteins EC:3.1.21.1 e.g. Swiss:P24855, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 Swiss:O43426, Sphingomyelinase EC:3.1.4.12 Swiss:P11889 and Nocturnin Swiss:O35710.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, C, D	DNA (43-MER)	-	-	-
A	DNA-(apurinic or apyrimidinic site) endonuclease, chloroplastic	DNA binding binding organic cyclic compound binding nucleic acid binding nuclease activity hydrolase activity, acting on ester bonds 3'-5' exonuclease activity hydrolase activity exonuclease activity catalytic activity DNA-(apurinic or apyrimidinic site) endonuclease activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid endonuclease activity DNA binding binding organic cyclic compound binding nucleic acid binding nuclease activity hydrolase activity, acting on ester bonds 3'-5' exonuclease activity hydrolase activity exonuclease activity catalytic activity DNA-(apurinic or apyrimidinic site) endonuclease activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid endonuclease activity phosphoric ester hydrolase activity phosphatase activity cation binding ion binding metal ion binding small molecule binding phosphodiesterase I activity phosphoric diester hydrolase activity	cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair regulation of cellular process cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	membrane-bounded organelle intracellular anatomical structure plastid plastid nucleoid intracellular membraneless organelle nucleoid intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure chloroplast nucleoid plastid stroma organelle membraneless organelle chloroplast stroma membrane-bounded organelle intracellular anatomical structure plastid plastid nucleoid intracellular membraneless organelle nucleoid intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure chloroplast nucleoid plastid stroma organelle membraneless organelle chloroplast stroma cytoplasm chloroplast

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005135	Endonuclease/exonuclease/phosphatase	Domain
A	IPR020848	AP endonuclease 1, conserved site	Conserved Site
A	IPR004808	AP endonuclease 1	Family
A	IPR003034	SAP domain	Domain
A	IPR036361	SAP domain superfamily	Homologous Superfamily
A	IPR036691	Endonuclease/exonuclease/phosphatase superfamily	Homologous Superfamily
A	IPR020847	AP endonuclease 1, binding site	Binding Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.