JAK2 JH2 Binders
Puleo, D.E., Schlessinger, J.To be published.
Experimental Data Snapshot
Starting Model: experimental
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Entity ID: 1 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
Tyrosine-protein kinase JAK2 | 289 | Homo sapiens | Mutation(s): 3 Gene Names: JAK2 EC: 2.7.10.2 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for O60674 (Homo sapiens) Explore O60674 Go to UniProtKB: O60674 | |||||
PHAROS: O60674 GTEx: ENSG00000096968 | |||||
Entity Groups | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | O60674 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 2 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
4SP (Subject of Investigation/LOI) Query on 4SP | C [auth A] | O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE C18 H22 N6 O3 S OWXORKPNCHJYOF-UHFFFAOYSA-N | |||
GOL Query on GOL | B [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 43.927 | α = 90 |
b = 57.658 | β = 110.52 |
c = 61.056 | γ = 90 |
Software Name | Purpose |
---|---|
PHENIX | refinement |
HKL-2000 | data reduction |
SCALEPACK | data scaling |
PHASER | phasing |
Funding Organization | Location | Grant Number |
---|---|---|
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | GM007324 |
Gilead Sciences | United States | YG-003-13 |